MX2022003108A - Composition and method for inhibiting tau protein accumulation, aggregation, and tangle formation. - Google Patents

Composition and method for inhibiting tau protein accumulation, aggregation, and tangle formation.

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Publication number
MX2022003108A
MX2022003108A MX2022003108A MX2022003108A MX2022003108A MX 2022003108 A MX2022003108 A MX 2022003108A MX 2022003108 A MX2022003108 A MX 2022003108A MX 2022003108 A MX2022003108 A MX 2022003108A MX 2022003108 A MX2022003108 A MX 2022003108A
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MX
Mexico
Prior art keywords
composition
aggregation
tau protein
protein accumulation
tangle formation
Prior art date
Application number
MX2022003108A
Other languages
Spanish (es)
Inventor
Tae Gyun Kim
Original Assignee
Innopeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innopeutics Corp filed Critical Innopeutics Corp
Publication of MX2022003108A publication Critical patent/MX2022003108A/en

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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Abstract

Disclosed are a composition and method for inhibiting tau protein accumulation, aggregation, or tangle, the composition containing neurons or glia having Nurr1 and/or Foxa2 genes introduced thereinto, wherein the composition and method can be utilized in the prevention or treatment of a cerebral nervous disease caused by tau protein accumulation, aggregation, or tangle formation.
MX2022003108A 2019-09-19 2020-09-15 Composition and method for inhibiting tau protein accumulation, aggregation, and tangle formation. MX2022003108A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20190115466 2019-09-19
KR1020200106368A KR20200115389A (en) 2019-09-19 2020-08-24 Composition and method of inhibiting tau protein accumulation/aggregation/plaque
PCT/KR2020/012429 WO2020242279A2 (en) 2019-09-19 2020-09-15 Composition and method for inhibiting tau protein accumulation, aggregation, and tangle formation

Publications (1)

Publication Number Publication Date
MX2022003108A true MX2022003108A (en) 2022-04-06

Family

ID=72884690

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022003108A MX2022003108A (en) 2019-09-19 2020-09-15 Composition and method for inhibiting tau protein accumulation, aggregation, and tangle formation.

Country Status (12)

Country Link
US (1) US20220202955A1 (en)
EP (1) EP4031189A4 (en)
JP (1) JP7366249B2 (en)
KR (2) KR20200115389A (en)
CN (1) CN114080239A (en)
AU (1) AU2020283965A1 (en)
BR (1) BR112022003484A2 (en)
CA (1) CA3144874C (en)
IL (1) IL289607A (en)
MX (1) MX2022003108A (en)
WO (1) WO2020242279A2 (en)
ZA (1) ZA202200539B (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011102847A1 (en) * 2010-02-16 2011-08-25 The Mclean Hospital Corporation Compositions and methods for treatment of parkinson's disease
KR101986366B1 (en) * 2016-02-26 2019-06-07 주식회사 이노퓨틱스 Therapeutic effects of Nurr1 and Foxa2 in inflammatory neurologic disorders by M1-to-M2 polarization of glial cells
KR20200033718A (en) * 2019-05-23 2020-03-30 주식회사 이노퓨틱스 Composition and method of inhibiting amyloid beta accumulation

Also Published As

Publication number Publication date
ZA202200539B (en) 2023-11-29
US20220202955A1 (en) 2022-06-30
CN114080239A (en) 2022-02-22
JP7366249B2 (en) 2023-10-20
EP4031189A2 (en) 2022-07-27
CA3144874A1 (en) 2020-12-03
WO2020242279A2 (en) 2020-12-03
JP2022549116A (en) 2022-11-24
CA3144874C (en) 2024-05-14
EP4031189A4 (en) 2022-12-14
IL289607A (en) 2022-03-01
KR20200115389A (en) 2020-10-07
BR112022003484A2 (en) 2022-05-24
WO2020242279A3 (en) 2021-03-04
KR20230098533A (en) 2023-07-04
AU2020283965A1 (en) 2022-01-06

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