MX2021014201A - Métodos relacionados con la tuberculosis. - Google Patents

Métodos relacionados con la tuberculosis.

Info

Publication number
MX2021014201A
MX2021014201A MX2021014201A MX2021014201A MX2021014201A MX 2021014201 A MX2021014201 A MX 2021014201A MX 2021014201 A MX2021014201 A MX 2021014201A MX 2021014201 A MX2021014201 A MX 2021014201A MX 2021014201 A MX2021014201 A MX 2021014201A
Authority
MX
Mexico
Prior art keywords
tuberculosis
subject
asymptomatic
active
infection
Prior art date
Application number
MX2021014201A
Other languages
English (en)
Inventor
Benjamin Swift
Catherine Rees
Original Assignee
Pbd Biotech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pbd Biotech Ltd filed Critical Pbd Biotech Ltd
Publication of MX2021014201A publication Critical patent/MX2021014201A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención se refiere a un método de diagnóstico de la enfermedad de la tuberculosis (TB) en un sujeto. El método comprende mezclar un bacteriófago específico de micobacterias con una muestra de células mononucleares de sangre periférica (PBMC) del sujeto, seguido de la determinación de la presencia o ausencia de una secuencia de ADN de micobacterias en el ADN aislado de la mezcla. La invención proporciona una prueba sensible y específica para la presencia de TB incipiente, es decir, una infección asintomática con un alto riesgo de desarrollar TB activa, o para la presencia de infección de tuberculosis latente (LTBI), es decir, una infección asintomática que no es probable que se desarrolle a TB activa, en un sujeto.
MX2021014201A 2019-05-21 2020-03-05 Métodos relacionados con la tuberculosis. MX2021014201A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1907157.0A GB201907157D0 (en) 2019-05-21 2019-05-21 Methods
PCT/GB2020/050524 WO2020234555A1 (en) 2019-05-21 2020-03-05 Methods relating to tuberculosis

Publications (1)

Publication Number Publication Date
MX2021014201A true MX2021014201A (es) 2022-02-21

Family

ID=67226285

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021014201A MX2021014201A (es) 2019-05-21 2020-03-05 Métodos relacionados con la tuberculosis.

Country Status (14)

Country Link
US (1) US20220243258A1 (es)
EP (1) EP3973078B1 (es)
JP (1) JP2022534370A (es)
KR (1) KR20220024127A (es)
CN (1) CN114072524A (es)
AU (1) AU2020277711B2 (es)
BR (1) BR112021023254A2 (es)
CA (1) CA3141503A1 (es)
EA (1) EA202192908A1 (es)
GB (1) GB201907157D0 (es)
MX (1) MX2021014201A (es)
SG (1) SG11202112880QA (es)
WO (1) WO2020234555A1 (es)
ZA (1) ZA202109307B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024092165A1 (en) * 2022-10-26 2024-05-02 The Administrators Of The Tulane Educational Fund Systems and methods for the automated diagnosis of mycobacterial infection

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776341B2 (en) * 2006-08-10 2010-08-17 Colorado State University Research Foundation Biomarkers of tuberculosis that distinguish disease categories: use as serodiagnostic antigens
CA2758124A1 (en) * 2008-04-19 2009-10-22 New York University Immunodominant mycobacterium tuberculosis peptides from cell wall proteins for early diagnosis and immunization
EP2353008A2 (en) * 2008-09-22 2011-08-10 Oregon Health and Science University Methods for detecting a mycobacterium tuberculosis infection
US8058022B2 (en) * 2009-07-27 2011-11-15 Indian Institute Of Science Diagnosis and monitoring of mycobacterium tuberculosis infection
GB201213567D0 (en) * 2012-07-31 2012-09-12 Proteinlogic Ltd Biomarkers
PL3052650T3 (pl) 2013-10-01 2019-09-30 The University Of Nottingham Wykrywanie mykobakterii za pomocą bakteriofagów
GB201401603D0 (en) * 2014-01-30 2014-03-19 Proteinlogic Ltd Biomarkers

Also Published As

Publication number Publication date
EP3973078A1 (en) 2022-03-30
ZA202109307B (en) 2023-04-26
US20220243258A1 (en) 2022-08-04
CN114072524A (zh) 2022-02-18
JP2022534370A (ja) 2022-07-29
AU2020277711A1 (en) 2022-01-06
GB201907157D0 (en) 2019-07-03
AU2020277711B2 (en) 2024-06-27
KR20220024127A (ko) 2022-03-03
EP3973078B1 (en) 2024-07-10
BR112021023254A2 (pt) 2022-02-08
EA202192908A1 (ru) 2022-03-23
EP3973078C0 (en) 2024-07-10
SG11202112880QA (en) 2021-12-30
CA3141503A1 (en) 2020-11-26
WO2020234555A1 (en) 2020-11-26

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