MX2021012197A - Polipeptidos de ectonucleotido pirofosfatasa (enpp1) y metodos de uso de los mismos. - Google Patents
Polipeptidos de ectonucleotido pirofosfatasa (enpp1) y metodos de uso de los mismos.Info
- Publication number
- MX2021012197A MX2021012197A MX2021012197A MX2021012197A MX2021012197A MX 2021012197 A MX2021012197 A MX 2021012197A MX 2021012197 A MX2021012197 A MX 2021012197A MX 2021012197 A MX2021012197 A MX 2021012197A MX 2021012197 A MX2021012197 A MX 2021012197A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- same
- enpp1
- polypeptides
- enpp1 polypeptides
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 101150017770 ENPP1 gene Proteins 0.000 title 1
- 101000812677 Homo sapiens Nucleotide pyrophosphatase Proteins 0.000 abstract 1
- 102100039306 Nucleotide pyrophosphatase Human genes 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/04—Phosphoric diester hydrolases (3.1.4)
- C12Y301/04001—Phosphodiesterase I (3.1.4.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
- C12Y306/01—Hydrolases acting on acid anhydrides (3.6) in phosphorus-containing anhydrides (3.6.1)
- C12Y306/01009—Nucleotide diphosphatase (3.6.1.9), i.e. nucleotide-pyrophosphatase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
LA PRESENTE DESCRIPCIÓN INCLUYE POLIPÉPTIDOS MUTANTES ENPP1 CON VIDA MEDIAS MEJORADAS IN VIVO.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962830230P | 2019-04-05 | 2019-04-05 | |
US202062983142P | 2020-02-28 | 2020-02-28 | |
US202062984650P | 2020-03-03 | 2020-03-03 | |
PCT/US2020/026643 WO2020206302A1 (en) | 2019-04-05 | 2020-04-03 | Enpp1 polypeptides and methods of using same |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021012197A true MX2021012197A (es) | 2022-01-06 |
Family
ID=72667412
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021012197A MX2021012197A (es) | 2019-04-05 | 2020-04-03 | Polipeptidos de ectonucleotido pirofosfatasa (enpp1) y metodos de uso de los mismos. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20220195402A1 (es) |
EP (1) | EP3947660A4 (es) |
JP (1) | JP2022527557A (es) |
KR (1) | KR20210149146A (es) |
CN (1) | CN113993993A (es) |
AU (1) | AU2020256253A1 (es) |
BR (1) | BR112021020037A2 (es) |
CA (1) | CA3136118A1 (es) |
IL (1) | IL286946A (es) |
MX (1) | MX2021012197A (es) |
TW (1) | TW202043292A (es) |
WO (1) | WO2020206302A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4162036A1 (en) | 2020-06-09 | 2023-04-12 | Inozyme Pharma, Inc. | Soluble enpp1 or enpp3 proteins and uses thereof |
WO2023191898A1 (en) * | 2022-03-30 | 2023-10-05 | Yale University | Method and compositions for treatment, amelioration, and/or prevention of diffuse idiopathic skeletal hyperostosis (dish) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2179383A1 (en) * | 1994-01-14 | 1995-07-20 | Ira D. Goldfine | Antagonists to insulin receptor tyrosine kinase inhibitor |
DK3460054T3 (da) * | 2013-03-15 | 2021-01-18 | Atyr Pharma Inc | Histidyl-tRNA-syntetase-Fc-konjugater |
JP6995627B2 (ja) * | 2015-05-19 | 2022-02-04 | イエール ユニバーシティ | 病的石灰化状態を治療するための組成物およびそれを使用する方法 |
-
2020
- 2020-04-03 JP JP2021559256A patent/JP2022527557A/ja active Pending
- 2020-04-03 US US17/601,387 patent/US20220195402A1/en active Pending
- 2020-04-03 WO PCT/US2020/026643 patent/WO2020206302A1/en unknown
- 2020-04-03 CA CA3136118A patent/CA3136118A1/en active Pending
- 2020-04-03 BR BR112021020037A patent/BR112021020037A2/pt unknown
- 2020-04-03 AU AU2020256253A patent/AU2020256253A1/en active Pending
- 2020-04-03 CN CN202080041580.2A patent/CN113993993A/zh active Pending
- 2020-04-03 EP EP20783595.0A patent/EP3947660A4/en active Pending
- 2020-04-03 KR KR1020217036178A patent/KR20210149146A/ko unknown
- 2020-04-03 MX MX2021012197A patent/MX2021012197A/es unknown
- 2020-04-06 TW TW109111502A patent/TW202043292A/zh unknown
-
2021
- 2021-10-04 IL IL286946A patent/IL286946A/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20220195402A1 (en) | 2022-06-23 |
WO2020206302A1 (en) | 2020-10-08 |
TW202043292A (zh) | 2020-12-01 |
AU2020256253A1 (en) | 2021-10-28 |
EP3947660A4 (en) | 2023-01-25 |
CA3136118A1 (en) | 2020-10-08 |
BR112021020037A2 (pt) | 2021-12-07 |
CN113993993A (zh) | 2022-01-28 |
IL286946A (en) | 2021-12-01 |
KR20210149146A (ko) | 2021-12-08 |
JP2022527557A (ja) | 2022-06-02 |
EP3947660A1 (en) | 2022-02-09 |
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