MX2021002069A - Uso del ghrp-6 como cardioprotector y cardiorestaurador tardio. - Google Patents
Uso del ghrp-6 como cardioprotector y cardiorestaurador tardio.Info
- Publication number
- MX2021002069A MX2021002069A MX2021002069A MX2021002069A MX2021002069A MX 2021002069 A MX2021002069 A MX 2021002069A MX 2021002069 A MX2021002069 A MX 2021002069A MX 2021002069 A MX2021002069 A MX 2021002069A MX 2021002069 A MX2021002069 A MX 2021002069A
- Authority
- MX
- Mexico
- Prior art keywords
- late
- ghrp
- cardioprotective
- cardiac
- medicament
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 5
- 230000000747 cardiac effect Effects 0.000 title abstract 4
- 230000003293 cardioprotective effect Effects 0.000 title abstract 4
- WZHKXNSOCOQYQX-FUAFALNISA-N (2s)-6-amino-2-[[(2r)-2-[[(2s)-2-[[(2s)-2-[[(2r)-2-[[(2s)-2-amino-3-(1h-imidazol-5-yl)propanoyl]amino]-3-(1h-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1h-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide Chemical compound C([C@H](N)C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCCN)C(N)=O)C1=CN=CN1 WZHKXNSOCOQYQX-FUAFALNISA-N 0.000 title 1
- 108010015153 growth hormone releasing hexapeptide Proteins 0.000 title 1
- 102100033367 Appetite-regulating hormone Human genes 0.000 abstract 1
- 208000009378 Low Cardiac Output Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 108010077689 gamma-aminobutyryl-2-methyltryptophyl-2-methyltryptophyl-2-methyltryptophyl-lysinamide Proteins 0.000 abstract 1
- 230000006266 hibernation Effects 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000004165 myocardium Anatomy 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se relaciona con el uso del péptido secretagogo de la hormona de crecimiento tipo 6 (GHRP-6) para la fabricación de un medicamento cardioprotector y cardiorestaurador tardío; dicho medicamento cardioprotector y cardiorestaurador tardío comprende el GHRP-6 y un excipiente o vehículo farmacéuticamente aceptable; también provee un método para el tratamiento de una enfermedad que cursa con bajo gasto cardíaco, donde se administra al individuo que lo necesita una cantidad terapéuticamente efectiva de un medicamento cardioprotector y cardiorestaurador tardío que comprende el GHRP-6; dicho medicamento permite tratar tardíamente, incluso días después, al miocardio que ha sufrido episodios de atontamiento, hibernación, isquemia y sus consecuencias.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20180093 | 2018-08-21 | ||
| PCT/CU2019/050007 WO2020038499A1 (es) | 2018-08-21 | 2019-08-19 | Uso del ghrp-6 como cardioprotector y cardiorestaurador tardio |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2021002069A true MX2021002069A (es) | 2021-04-28 |
Family
ID=68426044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021002069A MX2021002069A (es) | 2018-08-21 | 2019-08-19 | Uso del ghrp-6 como cardioprotector y cardiorestaurador tardio. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11564975B2 (es) |
| EP (1) | EP3842056B1 (es) |
| JP (1) | JP7360445B2 (es) |
| CN (1) | CN112955165A (es) |
| BR (1) | BR112021003118A2 (es) |
| CA (1) | CA3110173A1 (es) |
| ES (1) | ES2946005T3 (es) |
| MX (1) | MX2021002069A (es) |
| WO (1) | WO2020038499A1 (es) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU23157A1 (es) * | 2001-01-03 | 2006-07-18 | Ct Ingenieria Genetica Biotech | COMPOSICION FARMACéUTICA PARA EL TRATAMIENTO DEL DANO TISULAR DEBIDO A FALTA DE IRRIGACION SANGUINEA ARTERIAL |
-
2019
- 2019-08-19 MX MX2021002069A patent/MX2021002069A/es unknown
- 2019-08-19 CA CA3110173A patent/CA3110173A1/en active Pending
- 2019-08-19 CN CN201980069086.4A patent/CN112955165A/zh active Pending
- 2019-08-19 WO PCT/CU2019/050007 patent/WO2020038499A1/es unknown
- 2019-08-19 ES ES19797543T patent/ES2946005T3/es active Active
- 2019-08-19 BR BR112021003118-9A patent/BR112021003118A2/pt unknown
- 2019-08-19 JP JP2021509887A patent/JP7360445B2/ja active Active
- 2019-08-19 US US17/269,874 patent/US11564975B2/en active Active
- 2019-08-19 EP EP19797543.6A patent/EP3842056B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112021003118A2 (pt) | 2021-05-11 |
| EP3842056B1 (en) | 2023-05-03 |
| CA3110173A1 (en) | 2020-02-27 |
| JP7360445B2 (ja) | 2023-10-12 |
| US11564975B2 (en) | 2023-01-31 |
| US20210252109A1 (en) | 2021-08-19 |
| JP2021535117A (ja) | 2021-12-16 |
| EP3842056A1 (en) | 2021-06-30 |
| ES2946005T3 (es) | 2023-07-11 |
| WO2020038499A1 (es) | 2020-02-27 |
| CN112955165A (zh) | 2021-06-11 |
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