MX2019011789A - 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-y l)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation. - Google Patents

2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-y l)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation.

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Publication number
MX2019011789A
MX2019011789A MX2019011789A MX2019011789A MX2019011789A MX 2019011789 A MX2019011789 A MX 2019011789A MX 2019011789 A MX2019011789 A MX 2019011789A MX 2019011789 A MX2019011789 A MX 2019011789A MX 2019011789 A MX2019011789 A MX 2019011789A
Authority
MX
Mexico
Prior art keywords
difluorophenyl
difluoro
pyridin
substituted
ols
Prior art date
Application number
MX2019011789A
Other languages
Spanish (es)
Inventor
Deamicis Carl
Zhu Yuanming
Knueppel Daniel
Whiteker Greg
Choy Nakyen
Renga Jim
J Hoekstra William
T Sullenberger Michael
D Gustafson Gary
Original Assignee
Viamet Pharmaceuticals Nc Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viamet Pharmaceuticals Nc Inc filed Critical Viamet Pharmaceuticals Nc Inc
Publication of MX2019011789A publication Critical patent/MX2019011789A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Provided herein are 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2- yl)-3-(1H-tetrazol-1-yl)propan-2-ols and 1-(2,4-difluorophenyl)-2,2-difluoro-2-(5-substituted-pyridin-2- yl)ethanones and processes for their preparation.
MX2019011789A 2014-03-19 2016-09-15 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-y l)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation. MX2019011789A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461955680P 2014-03-19 2014-03-19

Publications (1)

Publication Number Publication Date
MX2019011789A true MX2019011789A (en) 2019-11-18

Family

ID=54145334

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016012060A MX2016012060A (en) 2014-03-19 2015-03-19 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-y l)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation.
MX2019011789A MX2019011789A (en) 2014-03-19 2016-09-15 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-y l)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2016012060A MX2016012060A (en) 2014-03-19 2015-03-19 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-y l)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation.

Country Status (11)

Country Link
US (2) US9988365B2 (en)
EP (1) EP3119756B9 (en)
JP (1) JP6633539B2 (en)
KR (1) KR102441243B1 (en)
CN (2) CN109678791B (en)
BR (1) BR112016021260B1 (en)
CA (1) CA2942982C (en)
IL (1) IL247832B (en)
MX (2) MX2016012060A (en)
WO (1) WO2015143192A1 (en)
ZA (1) ZA201606386B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10000465B2 (en) 2014-03-19 2018-06-19 Mycovia Pharmaceuticals, Inc. Antifungal compound process
US10173998B2 (en) 2014-03-19 2019-01-08 Mycovia Pharmaceuticals, Inc. Antifungal compound process
EP3119748A4 (en) 2014-03-19 2017-08-30 Viamet Pharmaceuticals, Inc. Antifungal compound process
CA2942231A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
WO2015143192A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation
CA2942979A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation
WO2015143142A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
WO2015143162A1 (en) * 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
AU2015231208B2 (en) 2014-03-19 2019-04-04 Mycovia Pharmaceuticals, Inc. Antifungal compound process
KR20180053393A (en) 2015-09-18 2018-05-21 브이피에스-3, 인크. Method of manufacturing antifungal compound
JP6898340B2 (en) * 2015-11-17 2021-07-07 コルテバ アグリサイエンス エルエルシー 4-((6- (2- (2,4-difluorophenyl) -1,1-difluoro-2-hydroxy-3- (1H-1,2,4-triazole-1-yl) propyl) pyridine-3) -Il) Oxy) Benzonitrile and preparation method
BR112018009924A2 (en) * 2015-11-17 2018-11-13 Dow Agrosciences Llc 4 - ((6- (2- (2,4-difluorphenyl) -1,1-difluoro-2-oxoethyl) pyridin-3-yl) oxy) benzonitrile and preparation processes
EP3710432A1 (en) 2017-11-13 2020-09-23 Bayer Aktiengesellschaft Tetrazolylpropyl derivatives and their use as fungicides
CN114573503B (en) * 2022-03-28 2024-04-09 浙江天宇药业股份有限公司 Method for preparing octreotide intermediate
CN114573557B (en) * 2022-03-28 2024-03-08 浙江天宇药业股份有限公司 Preparation method of octreonazole

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2854015B2 (en) 1978-12-14 1980-10-09 Dynamit Nobel Ag, 5210 Troisdorf Process for the preparation of! H-TetrazoI-1-acetic acids and certain esters thereof
CN1054853C (en) 1995-01-11 2000-07-26 上海三维制药公司 Prepn of 1-[2-(2,4-difluorophenyl)2,3-epoxypropyl]-1H-1,2,4-triazole as intermediate of fluconazole and its methyl sulphonate
US6509471B2 (en) * 1998-07-21 2003-01-21 Syngenta Participations Ag 3-substituted pyridine compounds and related synthesis
WO2000037459A1 (en) 1998-12-18 2000-06-29 Schering Corporation Tricyclic farnesyl protein transferase inhibitors
JP2000344744A (en) 1999-06-04 2000-12-12 Ss Pharmaceut Co Ltd Derivative of acetophenone and its production
US6809105B2 (en) * 2000-04-27 2004-10-26 Abbott Laboratories Diazabicyclic central nervous system active agents
WO2003015761A1 (en) * 2001-08-13 2003-02-27 Merck & Co., Inc. Selective estrogen receptor modulators
US8198448B2 (en) * 2006-07-14 2012-06-12 Amgen Inc. Fused heterocyclic derivatives and methods of use
KR100889937B1 (en) 2007-08-06 2009-03-20 한미약품 주식회사 Process for preparing voriconazole
KR101109215B1 (en) 2009-06-17 2012-01-30 보령제약 주식회사 New intermediates of Voriconazole and preparation of Voriconazole using the same
US20120088664A1 (en) 2009-06-18 2012-04-12 Basf Se Antifungal 1,2,4-triazolyl derivatives having a 5-sulfur subtituent
CN102811620B (en) 2010-01-25 2015-03-25 Chdi基金会股份有限公司 Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
EP2563771B1 (en) 2010-04-24 2015-11-25 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
WO2012177603A2 (en) 2011-06-19 2012-12-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
CA2839691A1 (en) 2011-06-19 2012-12-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
WO2012177728A1 (en) 2011-06-23 2012-12-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
AU2012352555B2 (en) 2011-12-11 2017-08-03 Nqp 1598, Ltd. Metalloenzyme inhibitor compounds
CN104135861A (en) 2012-01-20 2014-11-05 威尔金制药有限公司 Metalloenzyme inhibitor compounds
IN2014DN06792A (en) 2012-01-20 2015-05-22 Viamet Pharmaceuticals Inc
EP2894981B1 (en) * 2012-09-12 2019-12-04 Dow AgroSciences LLC Metalloenzyme inhibitor compounds
IN2015DN02109A (en) * 2012-09-26 2015-08-14 Zoetis Llc
AU2014209107B2 (en) 2013-01-28 2018-04-12 Viamet Pharmaceuticals (NC), Inc. Metalloenzyme inhibitor compounds
US9650334B2 (en) * 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9598340B2 (en) * 2013-04-05 2017-03-21 The Regents Of The University Of California Metal-catalyzed coupling of aryl and vinyl halides with alpha, alpha-difluorocarbonyl compounds
CA2913914C (en) 2013-05-28 2018-03-20 Viamet Pharmaceuticals, Inc. Fungicidal compositions
CA2915054A1 (en) 2013-06-12 2014-12-18 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
US10173998B2 (en) 2014-03-19 2019-01-08 Mycovia Pharmaceuticals, Inc. Antifungal compound process
WO2015143192A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation
WO2015143137A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
EP3119748A4 (en) 2014-03-19 2017-08-30 Viamet Pharmaceuticals, Inc. Antifungal compound process
WO2015143142A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
US10000465B2 (en) 2014-03-19 2018-06-19 Mycovia Pharmaceuticals, Inc. Antifungal compound process
WO2015143162A1 (en) * 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
CA2942979A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation
AU2015231208B2 (en) * 2014-03-19 2019-04-04 Mycovia Pharmaceuticals, Inc. Antifungal compound process
CA2942231A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
SI3271347T1 (en) * 2015-03-19 2022-11-30 Mycovia Pharmaceuticals, Inc. Antifungal compounds and processes for making
US11051514B2 (en) * 2015-05-18 2021-07-06 Mycovia Pharmaceuticals, Inc. Antifungal compounds
KR20180053393A (en) * 2015-09-18 2018-05-21 브이피에스-3, 인크. Method of manufacturing antifungal compound
JP6898340B2 (en) 2015-11-17 2021-07-07 コルテバ アグリサイエンス エルエルシー 4-((6- (2- (2,4-difluorophenyl) -1,1-difluoro-2-hydroxy-3- (1H-1,2,4-triazole-1-yl) propyl) pyridine-3) -Il) Oxy) Benzonitrile and preparation method
TWI679198B (en) 2015-11-17 2019-12-11 美商陶氏益農有限責任公司 Methods of making 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile
BR112018009915A2 (en) 2015-11-17 2018-11-13 Dow Agrosciences Llc 4 - ((6- (2- (2,4-difluorphenyl) -1,1-difluoro-2-hydroxy-3- (1h-1,2,4-triazol-1-yl) propyl) pyridin-3-one il) oxy) benzonitrile and preparation processes
BR112018009924A2 (en) 2015-11-17 2018-11-13 Dow Agrosciences Llc 4 - ((6- (2- (2,4-difluorphenyl) -1,1-difluoro-2-oxoethyl) pyridin-3-yl) oxy) benzonitrile and preparation processes
CN108779094B (en) 2015-12-30 2021-11-16 Nqp 1598公司 Metalloenzyme inhibitor compounds

Also Published As

Publication number Publication date
ZA201606386B (en) 2020-01-29
CN106132947A (en) 2016-11-16
MX2016012060A (en) 2017-01-19
CN109678791A (en) 2019-04-26
JP6633539B2 (en) 2020-01-22
US20170158667A1 (en) 2017-06-08
CN106132947B (en) 2019-08-09
CN109678791B (en) 2022-07-01
IL247832A0 (en) 2016-11-30
EP3119756B9 (en) 2021-08-25
JP2017507982A (en) 2017-03-23
BR112016021260B1 (en) 2020-05-26
US10301283B2 (en) 2019-05-28
WO2015143192A1 (en) 2015-09-24
KR102441243B1 (en) 2022-09-07
KR20160133446A (en) 2016-11-22
EP3119756A4 (en) 2017-09-20
EP3119756B1 (en) 2021-04-21
CA2942982A1 (en) 2015-09-24
IL247832B (en) 2019-10-31
CA2942982C (en) 2023-09-19
US9988365B2 (en) 2018-06-05
EP3119756A1 (en) 2017-01-25
US20180155324A1 (en) 2018-06-07

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