MX2019005701A - Sistemas y metodos para identificar y expresar agrupaciones de genes. - Google Patents

Sistemas y metodos para identificar y expresar agrupaciones de genes.

Info

Publication number
MX2019005701A
MX2019005701A MX2019005701A MX2019005701A MX2019005701A MX 2019005701 A MX2019005701 A MX 2019005701A MX 2019005701 A MX2019005701 A MX 2019005701A MX 2019005701 A MX2019005701 A MX 2019005701A MX 2019005701 A MX2019005701 A MX 2019005701A
Authority
MX
Mexico
Prior art keywords
methods
gene clusters
identifying
systems
expressing gene
Prior art date
Application number
MX2019005701A
Other languages
English (en)
Inventor
Thomas Naughton Brian
HARVEY Colin
Schlecht Ulrich
Elizabeth HILLENMEYER Maureen
Horecka Joe
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/469,452 external-priority patent/US10612032B2/en
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Publication of MX2019005701A publication Critical patent/MX2019005701A/es

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1079—Screening libraries by altering the phenotype or phenotypic trait of the host
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1089—Design, preparation, screening or analysis of libraries using computer algorithms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B10/00—ICT specially adapted for evolutionary bioinformatics, e.g. phylogenetic tree construction or analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/30—Detection of binding sites or motifs
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Se describen métodos para identificar agrupamientos de genes biosintéticos que incluyen genes para producir compuestos que interactúan con proteínas objetivo específicas. Algunos métodos se refieren a métodos bioinformáticos para identificar y/o priorizar agrupamiento de genes biosintéticos. También se describen sistemas relacionados, componentes, y herramientas para identificación y expresión de esos agrupamientos de genes.
MX2019005701A 2016-11-16 2017-11-16 Sistemas y metodos para identificar y expresar agrupaciones de genes. MX2019005701A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662423196P 2016-11-16 2016-11-16
US15/469,452 US10612032B2 (en) 2016-03-24 2017-03-24 Inducible production-phase promoters for coordinated heterologous expression in yeast
US201762481601P 2017-04-04 2017-04-04
PCT/US2017/062100 WO2018094110A2 (en) 2016-11-16 2017-11-16 Systems and methods for identifying and expressing gene clusters

Publications (1)

Publication Number Publication Date
MX2019005701A true MX2019005701A (es) 2019-10-07

Family

ID=62145753

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019005701A MX2019005701A (es) 2016-11-16 2017-11-16 Sistemas y metodos para identificar y expresar agrupaciones de genes.
MX2023006229A MX2023006229A (es) 2016-11-16 2019-05-15 Sistemas y metodos para identificar y expresar agrupaciones de genes.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2023006229A MX2023006229A (es) 2016-11-16 2019-05-15 Sistemas y metodos para identificar y expresar agrupaciones de genes.

Country Status (7)

Country Link
US (4) US20200040347A1 (es)
EP (1) EP3541936A4 (es)
CN (2) CN110268057B (es)
AU (1) AU2017363141B2 (es)
CA (1) CA3042726A1 (es)
MX (2) MX2019005701A (es)
WO (1) WO2018094110A2 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11795464B2 (en) 2016-03-24 2023-10-24 The Board Of Trustees Of The Leland Stanford Junior University Inducible production-phase promoters for coordinated heterologous expression in yeast

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2020000369A (es) * 2017-07-13 2020-08-17 Radici Chimica S P A Metodos biologicos para preparar terpenos.
CA3075528A1 (en) * 2017-09-14 2019-03-21 Lifemine Therapeutics, Inc. Human therapeutic targets and modulators thereof
WO2020046215A1 (en) * 2018-08-31 2020-03-05 Agency For Science, Technology And Research Methods for terpenoid production
CA3147414A1 (en) * 2019-07-17 2021-01-21 Generation Bio Co. Synthetic production of single-stranded adeno associated viral dna vectors
CN113053461B (zh) * 2021-03-15 2022-05-10 浙江大学 一种基于靶标的基因簇定向挖掘方法
CN113764034B (zh) * 2021-08-03 2023-09-22 腾讯科技（深圳）有限公司 基因组序列中潜在bgc的预测方法、装置、设备及介质
EP4434038A1 (en) * 2021-11-16 2024-09-25 LifeMine Therapeutics, Inc. Methods and systems for discovery of non-embedded target genes
AU2023205127A1 (en) * 2022-01-07 2024-07-04 Lifemine Therapeutics, Inc. Computational method to identify gene networks containing functionally-related genes
CN116978445B (zh) * 2023-08-03 2024-03-26 北京师范大学珠海校区 一种天然产物的结构预测系统、预测方法及设备

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO331096A0 (en) * 1996-10-29 1996-11-21 Commonwealth Scientific And Industrial Research Organisation Collagen products
CA2455013A1 (en) * 2001-07-27 2003-02-13 Francesca Storici Systems for in vivo site-directed mutagenesis using oligonucleotides
US20070061084A1 (en) * 2002-01-24 2007-03-15 Ecopia Biosciences, Inc. Method, system, and knowledge repository for identifying a secondary metabolite from a microorganism
US20130237435A1 (en) * 2010-09-22 2013-09-12 National Institute Of Advanced Industrial Science And Technology Gene cluster, gene searching/identification method, and apparatus for the method
AU2014227811C1 (en) * 2013-03-15 2018-09-27 Amyris, Inc. Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11795464B2 (en) 2016-03-24 2023-10-24 The Board Of Trustees Of The Leland Stanford Junior University Inducible production-phase promoters for coordinated heterologous expression in yeast

Also Published As

Publication number Publication date
CN110268057B (zh) 2024-03-29
US20210230611A1 (en) 2021-07-29
WO2018094110A3 (en) 2018-08-09
AU2017363141B2 (en) 2024-06-27
US20200040347A1 (en) 2020-02-06
EP3541936A2 (en) 2019-09-25
US20230215512A1 (en) 2023-07-06
AU2017363141A1 (en) 2019-05-23
CA3042726A1 (en) 2018-05-24
US20240120023A1 (en) 2024-04-11
CN118064425A (zh) 2024-05-24
WO2018094110A2 (en) 2018-05-24
MX2023006229A (es) 2023-06-15
CN110268057A (zh) 2019-09-20
EP3541936A4 (en) 2020-05-20

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