MX2017015617A - Inhibitor of igfbp3/tmem219 axis and diabetes. - Google Patents

Inhibitor of igfbp3/tmem219 axis and diabetes.

Info

Publication number
MX2017015617A
MX2017015617A MX2017015617A MX2017015617A MX2017015617A MX 2017015617 A MX2017015617 A MX 2017015617A MX 2017015617 A MX2017015617 A MX 2017015617A MX 2017015617 A MX2017015617 A MX 2017015617A MX 2017015617 A MX2017015617 A MX 2017015617A
Authority
MX
Mexico
Prior art keywords
diabetes
igfbp3
inhibitor
tmem219 axis
tmem219
Prior art date
Application number
MX2017015617A
Other languages
Spanish (es)
Other versions
MX367312B (en
Inventor
D'addio Francesca
Fiorina Paolo
Original Assignee
Ospedale San Raffaele Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ospedale San Raffaele Srl filed Critical Ospedale San Raffaele Srl
Publication of MX2017015617A publication Critical patent/MX2017015617A/en
Publication of MX367312B publication Critical patent/MX367312B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4745—Insulin-like growth factor binding protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)

Abstract

The present invention relates to the role of the IGFBP3/TMEM219 axis in the onset of diabetes and the related use of IGFBP3/TMEM219 axis inhibitors for the treatment and/or prevention of diabetes. The invention also relates to a method to identify a subject at risk of developing Type 1 and/or Type 2 diabetes and relative kit.
MX2017015617A 2015-06-04 2016-06-06 Inhibitor of igfbp3/tmem219 axis and diabetes. MX367312B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15170679 2015-06-04
EP16169222 2016-05-11
PCT/EP2016/062792 WO2016193497A1 (en) 2015-06-04 2016-06-06 Inhibitor of igfbp3/tmem219 axis and diabetes

Publications (2)

Publication Number Publication Date
MX2017015617A true MX2017015617A (en) 2018-11-09
MX367312B MX367312B (en) 2019-08-14

Family

ID=56121063

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017015617A MX367312B (en) 2015-06-04 2016-06-06 Inhibitor of igfbp3/tmem219 axis and diabetes.

Country Status (13)

Country Link
US (3) US20180169184A1 (en)
JP (1) JP6360265B2 (en)
KR (1) KR101978765B1 (en)
CN (1) CN107921132B (en)
AU (1) AU2016272045B2 (en)
BR (1) BR112017025998A2 (en)
CA (1) CA2988011C (en)
EA (1) EA033821B1 (en)
HK (1) HK1249449A1 (en)
IL (1) IL256096B (en)
MX (1) MX367312B (en)
NZ (1) NZ738389A (en)
WO (1) WO2016193497A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016272045B2 (en) 2015-06-04 2018-04-19 Ospedale San Raffaele Srl Inhibitor of IGFBP3/TMEM219 axis and diabetes
EA201792669A1 (en) 2015-06-04 2018-06-29 Оспедале Сан Раффаэле Срл IGFBP3 AND ITS APPLICATION
KR101943382B1 (en) 2017-09-19 2019-01-29 오토텔릭바이오 주식회사 A pharmaceutical composition comprising SGLT-2 inhibitor and angiotensin receptor blocker
KR102131359B1 (en) * 2018-09-07 2020-07-07 오토텔릭바이오 주식회사 A pharmaceutical composition with an improved stability
EP3632929A1 (en) 2018-10-02 2020-04-08 Ospedale San Raffaele S.r.l. Antibodies and uses thereof
EP4058476A1 (en) 2019-11-15 2022-09-21 Enthera S.r.l. Tmem219 antibodies and therapeutic uses thereof
JP2023503105A (en) 2019-11-21 2023-01-26 エンテラ・エッセ・エッレ・エッレ IGFBP3 Antibodies and Their Therapeutic Uses
CN114732896B (en) * 2022-06-09 2022-09-02 广东省科学院微生物研究所(广东省微生物分析检测中心) Application of skeletal muscle secretion factor Thbs4 in preparation of medicine for improving systemic glycolipid metabolism

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US5215534A (en) 1991-12-02 1993-06-01 Lawrence De Harde Safety syringe system
GB9603256D0 (en) 1996-02-16 1996-04-17 Wellcome Found Antibodies
CA2224859A1 (en) * 1996-04-17 1997-10-23 Amitabh Gaur Ligand inhibitors of insulin-like growth factor binding proteins and methods of use therefor
US6066464A (en) 1996-12-10 2000-05-23 Diagnostic Systems Laboratories, Inc. Immunoassay of IGF family of peptides, their binding proteins and related molecules in dried whole blood filter paper spots
CA2293829C (en) 1997-06-24 2011-06-14 Genentech, Inc. Methods and compositions for galactosylated glycoproteins
DE69840412D1 (en) 1997-10-31 2009-02-12 Genentech Inc METHODS AND COMPOSITIONS CONTAINING GLYCOPROTEIN GLYCOR FORMS
DE69942021D1 (en) 1998-04-20 2010-04-01 Glycart Biotechnology Ag GLYCOSYLATION ENGINEERING OF ANTIBODIES TO IMPROVE ANTIBODY-DEPENDENT CELL-EMITTED CYTOTOXICITY
US6448086B1 (en) 2000-01-18 2002-09-10 Diagnostic Systems Laboratories, Inc. Insulin-like growth factor system and cancer
WO2001087238A2 (en) 2000-05-17 2001-11-22 Oregon Health & Sciences University Induction of apoptosis and cell growth inhibition by protein 4.33
CA2421447C (en) 2000-09-08 2012-05-08 Universitat Zurich Collections of repeat proteins comprising repeat modules
WO2002034916A2 (en) 2000-10-27 2002-05-02 Oregon Health And Science University Novel mutant igbp-3 molecules that do not bind to igfs, but retain their ability to functionally bind igfbp-3 receptor
ES2727425T3 (en) 2000-12-12 2019-10-16 Medimmune Llc Molecules with prolonged half-lives, compositions and uses thereof
CA2838062C (en) 2001-08-03 2015-12-22 Roche Glycart Ag Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
WO2003035835A2 (en) 2001-10-25 2003-05-01 Genentech, Inc. Glycoprotein compositions
US20040093621A1 (en) 2001-12-25 2004-05-13 Kyowa Hakko Kogyo Co., Ltd Antibody composition which specifically binds to CD20
ES2341009T3 (en) 2003-11-05 2010-06-14 Roche Glycart Ag CD20 ANTIBODIES WITH AFFINITY OF UNION TO FC RECEPTORS AND EFFECTIVE FUNCTION.
BRPI0516284A (en) 2004-09-23 2008-09-02 Genentech Inc cysteine-constructed antibody, method of selecting antibodies, drug-antibody conjugated compounds, pharmaceutical composition, method for killing or inhibiting tumor cell proliferation, methods of inhibiting cell proliferation and tumor cell growth, manufactured article and method to produce a compound
US20090170133A1 (en) 2005-04-19 2009-07-02 Irena Kirman Intact IGFBP-3 as a Colon Cancer Risk Factor in Patients With Inflammatory Bowel Disease
KR20140053410A (en) 2005-08-19 2014-05-07 아보트 러보러터리즈 Dual variable domain immunoglobulin and uses thereof
US8309525B2 (en) 2007-05-30 2012-11-13 Albert Einstein College Of Medicine Of Yeshiva University Treatment of type 2 diabetes, metabolic syndrome, myocardial injury and neurodegeneration with humanin and analogs thereof
TWI586806B (en) 2010-04-23 2017-06-11 建南德克公司 Production of heteromultimeric proteins
US9427531B2 (en) 2010-06-28 2016-08-30 Sanofi-Aventis Deutschland Gmbh Auto-injector
CA2825357C (en) 2011-02-24 2018-07-10 Inserm (Institut National De La Sante Et De La Recherche Medicale) Igfbp-3 derivatives and uses thereof
BR112014014418A2 (en) * 2011-12-15 2019-09-24 Nat Res Council Canada soluble igf receptor fc fusion proteins and uses thereof
WO2013152989A2 (en) 2012-04-10 2013-10-17 Eth Zurich Biomarker assay and uses thereof for diagnosis, therapy selection, and prognosis of cancer
US9248242B2 (en) 2012-04-20 2016-02-02 Safety Syringes, Inc. Anti-needle stick safety device for injection device
US20140155827A1 (en) 2012-12-03 2014-06-05 Mylan, Inc. Medicament information system and method
US20160011207A1 (en) 2012-12-07 2016-01-14 Virginia Commonwealth University Diagnosis and therapy of chronic inflammation-induced disorders
BR112017008045A2 (en) 2014-10-23 2017-12-19 Janssen Pharmaceutica Nv compounds as nik inhibitors
EA201792669A1 (en) 2015-06-04 2018-06-29 Оспедале Сан Раффаэле Срл IGFBP3 AND ITS APPLICATION
AU2016272045B2 (en) 2015-06-04 2018-04-19 Ospedale San Raffaele Srl Inhibitor of IGFBP3/TMEM219 axis and diabetes

Also Published As

Publication number Publication date
IL256096B (en) 2018-08-30
JP2018516975A (en) 2018-06-28
JP6360265B2 (en) 2018-07-18
AU2016272045A1 (en) 2018-01-18
EA033821B1 (en) 2019-11-29
US11020453B2 (en) 2021-06-01
KR20180011842A (en) 2018-02-02
CA2988011C (en) 2021-03-23
US20180169184A1 (en) 2018-06-21
WO2016193497A1 (en) 2016-12-08
EA201792641A1 (en) 2018-03-30
MX367312B (en) 2019-08-14
CA2988011A1 (en) 2016-12-08
BR112017025998A2 (en) 2018-08-14
US20180243367A1 (en) 2018-08-30
IL256096A (en) 2018-01-31
CN107921132B (en) 2021-05-07
HK1249449A1 (en) 2018-11-02
AU2016272045B2 (en) 2018-04-19
NZ738389A (en) 2019-02-22
US20210169973A1 (en) 2021-06-10
KR101978765B1 (en) 2019-05-15
CN107921132A (en) 2018-04-17

Similar Documents

Publication Publication Date Title
NZ738389A (en) Inhibitor of igfbp3/tmem219 axis and diabetes
IL259787A (en) Mutant isocitrate dehydrogenase 1(idh1) inhibitors for treating malignancies
IL261721A (en) Combinations of lsd1 inhibitors for use in the treatment of solid tumors
MX2019003623A (en) Compositions and methods for treating ophthalmic conditions.
IL261717B (en) Combinations of lsd1 inhibitors for the treatment of hematological malignancies
IL275496A (en) Glycolate oxidase inhibitors for the treatment of disease
MX2018016057A (en) Compositions and methods for treating cardiovascular disease.
MX2021011946A (en) C1-inh compositions and methods for the prevention and treatment of disorders associated with c1 esterase inhibitor deficency.
MX2020013808A (en) Gremlin-1 antagonist for the prevention and treatment of cancer.
PH12016500270A1 (en) Combination of a mek inhibitor and an erk inhibitor for use in treatment of hyperproliferative diseases
PH12017501990B1 (en) Imidazopyrazinones as pde1 inhibitors
MX2018001737A (en) Mechanism of resistance to bet bromodomain inhibitors.
PL3302519T3 (en) Ornithodoros moubata complement inhibitor for use in the treatment of acute graft versus host disease
MX2018008732A (en) Inhibition of allergic reaction using an il-33 inhibitor.
EA201890728A3 (en) TREATMENT OF NTCP ATHEROSCLEROSIS, PRIMARY BILIARY CIRRHOSIS AND DISEASES ASSOCIATED WITH NRLP3-INFLAMMASOMA INHIBITORS
MX2019005831A (en) Aptamers for use in inhibition and/or suppression of tlr9 activation.
MX2017006019A (en) Apilimod for use in the treatment of melanoma.
MX2017014782A (en) Method for the treatment of neurological disease.
EA031679B9 (en) Tetrahydroquinoline derivatives as bromodomain inhibitors
MA40590A (en) PHARMACEUTICAL COMPOSITION AND THERAPEUTIC COMBINATION COMPRISING A CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITOR AND HMG CoA REDUCTASE INHIBITORS
MX2018001493A (en) Gdf-15 as a haematological toxicity biomarker.
EP3429567A4 (en) Methods and compositions for treating obesity and/or diabetes and for identifying candidate treatment agents
MX2020012782A (en) Ccr5 inhibitor for use in treating cancer.
NZ724799A (en) Compositions and methods for the treatment or prevention of neurodegenerative disorders
MX2019005194A (en) Combinations of fgfr4 inhibitors and bile acid sequestrants.

Legal Events

Date Code Title Description
FG Grant or registration