MX2016014459A - Formas de cristal. - Google Patents

Formas de cristal.

Info

Publication number
MX2016014459A
MX2016014459A MX2016014459A MX2016014459A MX2016014459A MX 2016014459 A MX2016014459 A MX 2016014459A MX 2016014459 A MX2016014459 A MX 2016014459A MX 2016014459 A MX2016014459 A MX 2016014459A MX 2016014459 A MX2016014459 A MX 2016014459A
Authority
MX
Mexico
Prior art keywords
glass forms
compound
forms
figures
invention describes
Prior art date
Application number
MX2016014459A
Other languages
English (en)
Other versions
MX383165B (es
Inventor
G Fickes Michael
Califano Jean-Christophe
Fredrik NORDSTROEM Lars
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of MX2016014459A publication Critical patent/MX2016014459A/es
Publication of MX383165B publication Critical patent/MX383165B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)

Abstract

La presente invención describe formas cristalinas del Compuesto I. En una modalidad, una forma cristalina del Compuesto I tiene picos característicos en el patrón PXRD como se muestra en una de las Figuras 1-10.
MX2016014459A 2014-05-09 2015-05-08 Polimorfos cristalinos de {(2s, 3r)-1-[(2s)-2-{5-[(2r, 5r)-1-{3,5-difluoro-4-[4-(4-fluorofenil)piperidin-1-il]fenil}-5(6-fluoro-2-{(2s)-1-[n-(metoxicarbonil)-o-metil-l-treonil]pirrolidin-2-il}-1h-benzimidazol-5il)pirrolidin-2-il]-6-fluoro-1h-benzimidazol-2-il}pirrolidin-1-il]-3-metoxi-1-oxobutan-2-il}carbamato de metilo. MX383165B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461991242P 2014-05-09 2014-05-09
PCT/US2015/029842 WO2015171993A1 (en) 2014-05-09 2015-05-08 Crystal forms

Publications (2)

Publication Number Publication Date
MX2016014459A true MX2016014459A (es) 2017-02-23
MX383165B MX383165B (es) 2025-03-13

Family

ID=53284512

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016014459A MX383165B (es) 2014-05-09 2015-05-08 Polimorfos cristalinos de {(2s, 3r)-1-[(2s)-2-{5-[(2r, 5r)-1-{3,5-difluoro-4-[4-(4-fluorofenil)piperidin-1-il]fenil}-5(6-fluoro-2-{(2s)-1-[n-(metoxicarbonil)-o-metil-l-treonil]pirrolidin-2-il}-1h-benzimidazol-5il)pirrolidin-2-il]-6-fluoro-1h-benzimidazol-2-il}pirrolidin-1-il]-3-metoxi-1-oxobutan-2-il}carbamato de metilo.
MX2020006006A MX2020006006A (es) 2014-05-09 2016-11-04 Polimorfos cristalinos de {(2s,3r)-1-[(2s)-2-{5-[(2r,5r)-1-{3,5-di fluoro-4-[4-(4-fluorofenil)piperidin-1-il]fenil}-5-(6-fluoro-2-{( 2s)-1-[n-(metoxicarbonil)-o-metil-l-treonil]pirrolidin-2-il}-1h-b enzimidazol-5-il)pirrolidin-2-il]-6-fluoro-1h-benzimidazol-2-il}p irrolidin-1-il]-3-metoxi-1-oxobutan-2-il}carbamato de metilo.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2020006006A MX2020006006A (es) 2014-05-09 2016-11-04 Polimorfos cristalinos de {(2s,3r)-1-[(2s)-2-{5-[(2r,5r)-1-{3,5-di fluoro-4-[4-(4-fluorofenil)piperidin-1-il]fenil}-5-(6-fluoro-2-{( 2s)-1-[n-(metoxicarbonil)-o-metil-l-treonil]pirrolidin-2-il}-1h-b enzimidazol-5-il)pirrolidin-2-il]-6-fluoro-1h-benzimidazol-2-il}p irrolidin-1-il]-3-metoxi-1-oxobutan-2-il}carbamato de metilo.

Country Status (8)

Country Link
US (2) US9593078B2 (es)
EP (2) EP3140284A1 (es)
JP (4) JP2017515897A (es)
CN (2) CN115197197A (es)
AU (2) AU2015255784A1 (es)
CA (1) CA2945205C (es)
MX (2) MX383165B (es)
WO (1) WO2015171993A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017515897A (ja) 2014-05-09 2017-06-15 アッヴィ・インコーポレイテッド 結晶形
US20160090373A1 (en) * 2014-09-29 2016-03-31 Abbvie Inc. Solid forms of anti-viral compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2004001884A1 (es) * 2003-08-04 2005-06-03 Pfizer Prod Inc Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros.
US7741347B2 (en) * 2007-05-17 2010-06-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8937150B2 (en) * 2009-06-11 2015-01-20 Abbvie Inc. Anti-viral compounds
WO2013025449A1 (en) * 2011-08-16 2013-02-21 Merck Sharp & Dohme Corp. Use of inorganic matrix and organic polymer combinations for preparing stable amorphous dispersions
JP2017515897A (ja) 2014-05-09 2017-06-15 アッヴィ・インコーポレイテッド 結晶形
JP2019077923A (ja) * 2017-10-25 2019-05-23 トヨタ自動車株式会社 金属ナノ粒子の製造装置

Also Published As

Publication number Publication date
JP7300424B2 (ja) 2023-06-29
EP4234028A2 (en) 2023-08-30
WO2015171993A1 (en) 2015-11-12
CN106458989A (zh) 2017-02-22
CA2945205A1 (en) 2015-11-12
MX383165B (es) 2025-03-13
AU2020203494A1 (en) 2020-06-18
JP2019189602A (ja) 2019-10-31
AU2020203494B2 (en) 2022-08-18
EP4234028A3 (en) 2024-01-17
CA2945205C (en) 2024-09-10
USRE48923E1 (en) 2022-02-08
AU2015255784A1 (en) 2016-10-27
JP2020172515A (ja) 2020-10-22
US9593078B2 (en) 2017-03-14
US20150322047A1 (en) 2015-11-12
JP2022133438A (ja) 2022-09-13
CN115197197A (zh) 2022-10-18
EP3140284A1 (en) 2017-03-15
MX2020006006A (es) 2020-08-17
JP2017515897A (ja) 2017-06-15

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