MX2015011375A - Bicyclo [2.2.1] acid gpr120 modulators. - Google Patents

Bicyclo [2.2.1] acid gpr120 modulators.

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Publication number
MX2015011375A
MX2015011375A MX2015011375A MX2015011375A MX2015011375A MX 2015011375 A MX2015011375 A MX 2015011375A MX 2015011375 A MX2015011375 A MX 2015011375A MX 2015011375 A MX2015011375 A MX 2015011375A MX 2015011375 A MX2015011375 A MX 2015011375A
Authority
MX
Mexico
Prior art keywords
bicyclo
gpr120 modulators
acid
acid gpr120
modulators
Prior art date
Application number
MX2015011375A
Other languages
Spanish (es)
Other versions
MX362919B (en
Inventor
Ying Wang
Yan Shi
Peter T W Cheng
Shung C Wu
Zhang Hao
Original Assignee
Squibb Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb Bristol Myers Co filed Critical Squibb Bristol Myers Co
Publication of MX2015011375A publication Critical patent/MX2015011375A/en
Publication of MX362919B publication Critical patent/MX362919B/en

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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
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    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
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    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
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    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
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    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Abstract

The present invention provides compounds of Formula (I): (I) or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulators which may be used as medicaments.
MX2015011375A 2013-03-14 2014-03-13 Bicyclo [2.2.1] acid gpr120 modulators. MX362919B (en)

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PCT/US2014/025153 WO2014159794A2 (en) 2013-03-14 2014-03-13 Bicyclo [2.2.1] acid gpr120 modulators

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US9580420B2 (en) * 2014-08-06 2017-02-28 Bristol-Meyers Squibb Company Process for the preparation of 4-(8-(2-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)bicyclo[2.2.1]heptan-1-ol and novel intermediates therefor
US9938222B2 (en) 2014-09-09 2018-04-10 Bristol-Myers Squibb Company Cyclopropanecarboxylic acid GPR120 modulators
ES2760266T3 (en) 2014-09-09 2020-05-13 Bristol Myers Squibb Co Phenyl- (aza) cycloalkyl carboxylic acid GPR120 modulators
WO2016040223A1 (en) 2014-09-09 2016-03-17 Bristol-Myers Squibb Company Cyclobutane containing carboxylic acid gpr120 modulators
WO2016105118A2 (en) 2014-12-24 2016-06-30 주식회사 엘지생명과학 Biaryl derivative as gpr120 agonist
EP3509587B1 (en) 2016-09-12 2023-12-06 Valo Health, Inc. Monocyclic compounds useful as gpr120 modulators
CA3090445A1 (en) 2018-03-15 2019-09-19 Axxam S.P.A. Substituted pyrazoles ffa4/gpr120 receptor agonists

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US5614492A (en) 1986-05-05 1997-03-25 The General Hospital Corporation Insulinotropic hormone GLP-1 (7-36) and uses thereof
FR2746101B1 (en) * 1996-03-14 1998-04-30 BICYCLIC-AROMATIC COMPOUNDS
US6008234A (en) * 1996-09-12 1999-12-28 Berlex Laboratories, Inc. Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
SK287535B6 (en) * 1999-04-30 2011-01-04 Pfizer Products Inc. Glucocorticoid receptor modulators
FR2849599B1 (en) * 2003-01-07 2006-12-29 Merck Sante Sas USE OF KYNURENINE-3-HYDROXYLASE INHIBITORS FOR THE TREATMENT OF DIABETES
AU2008311355B2 (en) * 2007-10-10 2012-01-19 Amgen Inc. Substituted biphenyl GPR40 modulators
JPWO2012124744A1 (en) 2011-03-14 2014-07-24 大正製薬株式会社 Nitrogen-containing fused heterocyclic compounds
US8962660B2 (en) 2013-03-14 2015-02-24 Bristol-Myers Squibb Company Oxabicyclo [2.2.2] acid GPR120 modulators

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CA2905428A1 (en) 2014-10-02
US20160016880A1 (en) 2016-01-21
CN105189439B (en) 2017-12-29
EA201591795A1 (en) 2015-12-30
SG11201506796XA (en) 2015-09-29
AU2014244474A1 (en) 2015-11-05
AU2014244474B2 (en) 2018-04-26
IL241245A (en) 2017-12-31
IL241245A0 (en) 2015-11-30
KR20150127208A (en) 2015-11-16
EP2970092B1 (en) 2016-12-14
WO2014159794A3 (en) 2014-12-11
WO2014159794A2 (en) 2014-10-02
JP2016520517A (en) 2016-07-14
US9518000B2 (en) 2016-12-13
BR112015021990A2 (en) 2017-07-18
CN105189439A (en) 2015-12-23
EP2970092A2 (en) 2016-01-20

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