MX2013005507A - Methods of treating tumors. - Google Patents

Methods of treating tumors.

Info

Publication number
MX2013005507A
MX2013005507A MX2013005507A MX2013005507A MX2013005507A MX 2013005507 A MX2013005507 A MX 2013005507A MX 2013005507 A MX2013005507 A MX 2013005507A MX 2013005507 A MX2013005507 A MX 2013005507A MX 2013005507 A MX2013005507 A MX 2013005507A
Authority
MX
Mexico
Prior art keywords
treating tumors
methods
pak1
hyper
administering
Prior art date
Application number
MX2013005507A
Other languages
Spanish (es)
Inventor
Klaus P Hoeflich
Hartmut Koeppen
Christy C Ong
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2013005507A publication Critical patent/MX2013005507A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/105—Persulfides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention relates to a method of treating tumors wherein PAK1 is over- expressed or amplified by co-administering a PAK1 inhibitor and a second anti-hyper- proliferative agent.
MX2013005507A 2010-11-17 2011-11-14 Methods of treating tumors. MX2013005507A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41467110P 2010-11-17 2010-11-17
US201161523062P 2011-08-12 2011-08-12
PCT/EP2011/070008 WO2012065935A1 (en) 2010-11-17 2011-11-14 Methods of treating tumors

Publications (1)

Publication Number Publication Date
MX2013005507A true MX2013005507A (en) 2013-07-17

Family

ID=44993549

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013005507A MX2013005507A (en) 2010-11-17 2011-11-14 Methods of treating tumors.

Country Status (9)

Country Link
EP (1) EP2640369A1 (en)
JP (1) JP2013542965A (en)
KR (1) KR20130121122A (en)
CN (1) CN103298461A (en)
BR (1) BR112013012175A2 (en)
CA (1) CA2817133A1 (en)
MX (1) MX2013005507A (en)
RU (1) RU2013126036A (en)
WO (1) WO2012065935A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2535176T3 (en) 2009-09-28 2015-05-06 Qilu Pharmaceutical Co., Ltd 4- (substituted anilino) quinazoline derivatives as tyrosine kinase inhibitors
MX2015003535A (en) 2012-09-19 2015-07-14 Novartis Ag Dihydropyrrolidino-pyrimidines as kinase inhibitors.
US20140271634A1 (en) * 2013-03-14 2014-09-18 The Regents Of The University Of California Combinations of a mek inhibitor compound with an her3/egfr inhibitor compound and methods of use
EP3416623B1 (en) 2016-02-15 2021-08-11 University of Georgia Research Foundation, Inc. Ipa-3-loaded liposomes and methods of use thereof
CN109311908B (en) * 2016-06-16 2021-05-07 哈尔滨珍宝制药有限公司 Dihydropyrazole azepinoids as Akt inhibitors
WO2020235973A1 (en) * 2019-05-22 2020-11-26 주식회사 보로노이 Novel use of pyrrolo-pyridine derivative compound for prevention and/or treatment of cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS51891B (en) 2005-01-10 2012-02-29 Pfizer Inc. Pyrropyrazoles, potent kinase inhibitors
EP1869052A1 (en) 2005-04-06 2007-12-26 AstraZeneca AB Substituted heterocycles and their use as chk1, pdk1 and pak inhibitors
WO2007023382A2 (en) 2005-08-25 2007-03-01 Pfizer Inc. Pyrimidine amino pyrazole compounds, potent kinase inhibitors
US7884117B2 (en) 2005-12-21 2011-02-08 Pfizer Inc. Carbonylamino pyrrolopyrazoles, potent kinase inhibitors
CA2691251A1 (en) * 2007-06-19 2008-12-24 Yoshikazu Ohta Preventive/remedy for cancer
US7998688B2 (en) * 2008-03-07 2011-08-16 OSI Pharmaceuticals, LLC Inhibition of EMT induction in tumor cells by anti-cancer agents
US8674095B2 (en) 2008-12-19 2014-03-18 Afraxis Holdings, Inc. Compounds for treating neuropsychiatric conditions

Also Published As

Publication number Publication date
JP2013542965A (en) 2013-11-28
WO2012065935A1 (en) 2012-05-24
CA2817133A1 (en) 2012-05-24
BR112013012175A2 (en) 2019-09-24
CN103298461A (en) 2013-09-11
KR20130121122A (en) 2013-11-05
EP2640369A1 (en) 2013-09-25
RU2013126036A (en) 2014-12-27

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal