MX2011011082A - Novel amide and amidine derivatives and uses thereof. - Google Patents
Novel amide and amidine derivatives and uses thereof.Info
- Publication number
- MX2011011082A MX2011011082A MX2011011082A MX2011011082A MX2011011082A MX 2011011082 A MX2011011082 A MX 2011011082A MX 2011011082 A MX2011011082 A MX 2011011082A MX 2011011082 A MX2011011082 A MX 2011011082A MX 2011011082 A MX2011011082 A MX 2011011082A
- Authority
- MX
- Mexico
- Prior art keywords
- amidine derivatives
- novel amide
- type
- disorders
- obesity
- Prior art date
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- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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Abstract
The present invention relates to inhibitors of 11- β-hydroxysteroid dehydrogenase type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17094309P | 2009-04-20 | 2009-04-20 | |
PCT/US2010/031660 WO2010123838A2 (en) | 2009-04-20 | 2010-04-20 | Novel amide and amidine derivatives and uses thereof |
Publications (1)
Publication Number | Publication Date |
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MX2011011082A true MX2011011082A (en) | 2011-11-04 |
Family
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MX2011011082A MX2011011082A (en) | 2009-04-20 | 2010-04-20 | Novel amide and amidine derivatives and uses thereof. |
Country Status (5)
Country | Link |
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JP (2) | JP5848698B2 (en) |
CN (2) | CN103772239B (en) |
CA (1) | CA2757866A1 (en) |
MX (1) | MX2011011082A (en) |
WO (1) | WO2010123838A2 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5848698B2 (en) * | 2009-04-20 | 2016-01-27 | アッヴィ・インコーポレイテッド | Novel amide and amidine derivatives and their use |
EA201590696A1 (en) * | 2012-11-06 | 2015-08-31 | Эли Лилли Энд Компани | NEW BENZYL SULPHONAMIDE CONNECTIONS SUITABLE AS MOGAT-2 INHIBITORS |
CN104628673A (en) * | 2015-02-10 | 2015-05-20 | 佛山市赛维斯医药科技有限公司 | Nitrile benzene thiazolecarboxamide type compound containing tert-butylamidine structure and application thereof |
CN104592150A (en) * | 2015-02-10 | 2015-05-06 | 佛山市赛维斯医药科技有限公司 | Cyclopropyl amidine structure containing cyanobenzene thiazolecarboxylic acid amide compound and application thereof |
CN104672164A (en) * | 2015-02-10 | 2015-06-03 | 佛山市赛维斯医药科技有限公司 | SGLT2/SGLT1 double-target inhibitor containing benzene amidine structure as well as preparation method and application of inhibitor |
CN104628672A (en) * | 2015-02-10 | 2015-05-20 | 佛山市赛维斯医药科技有限公司 | Alkoxyphenylthiazole carboxylic acid amide compounds containing phenylamidine structures and application |
CN104672165B (en) * | 2015-02-10 | 2016-06-01 | 佛山市赛维斯医药科技有限公司 | One class is containing alkoxyphenyl radical thiazole carboxylic acid amides's class two target spot inhibitor, the Preparation Method And The Use of cyclopropyl amidine structure |
CN104592152A (en) * | 2015-02-10 | 2015-05-06 | 佛山市赛维斯医药科技有限公司 | Amidine structure containing nitrobenzene thiazolecarboxylic acid amide dual-target inhibitor, as well as preparation method and application thereof |
CN104910097A (en) * | 2015-02-10 | 2015-09-16 | 佛山市赛维斯医药科技有限公司 | Halogenophenylthiazole carboxylic acid amide compounds containing phenylamidine structures as well as preparation method and application thereof |
CN104672166A (en) * | 2015-02-10 | 2015-06-03 | 佛山市赛维斯医药科技有限公司 | Cyanophenyl thiazolecarboxylic acid amide double-target inhibitor containing amidine structure as well as preparation method and application of inhibitor |
CN104592148A (en) * | 2015-02-10 | 2015-05-06 | 佛山市赛维斯医药科技有限公司 | Cyclopropyl amidine structure containing nitrobenzene thiazolecarboxylic acid amide compound and application thereof |
CN104710382A (en) * | 2015-02-10 | 2015-06-17 | 佛山市赛维斯医药科技有限公司 | Halogeneated phenyl thiazole carboxylic acid amides compounds containing tertiary butyl amidine structures and application |
CN104557766A (en) * | 2015-02-10 | 2015-04-29 | 佛山市赛维斯医药科技有限公司 | Nitrobenzene thiazolecarboxylic acid amide compounds containing tert-butylformamidine structure and application thereof |
CN110850012B (en) * | 2018-08-21 | 2022-07-08 | 四川弘远药业有限公司 | Detection method of 1- (2, 3-dichlorophenyl) piperazine hydrochloride and related substances thereof |
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US2450386A (en) * | 1945-09-04 | 1948-09-28 | Boots Pure Drug Co Ltd | Manufacture of compounds containing amidine groups |
GB1306139A (en) * | 1970-08-06 | 1973-02-07 | ||
US4156014A (en) * | 1977-03-21 | 1979-05-22 | The Upjohn Company | N-(2-aminocycloheptyl)alkanoylanilides and in the treatment of depression |
FR2387977A1 (en) * | 1977-04-19 | 1978-11-17 | Hoechst France | MANUFACTURING PROCESS OF THIENYL-2 ACETIC ACID |
JPS562957A (en) * | 1979-06-18 | 1981-01-13 | Otsuka Pharmaceut Factory Inc | N-adamantylthioamide derivative |
CA1157774A (en) * | 1980-07-30 | 1983-11-29 | Anthony Cerami | Method for the reduction of mucin viscosity |
NZ228329A (en) * | 1988-03-18 | 1991-12-23 | Mitsui Toatsu Chemicals | Catechol derivatives and pharmaceutical compositions thereof |
JPH0660141B2 (en) * | 1989-09-12 | 1994-08-10 | 三井東圧化学株式会社 | Dihydrocaffeic acid derivative and therapeutic agent containing it as an active ingredient |
WO1992002490A1 (en) * | 1990-08-10 | 1992-02-20 | Mitsui Toatsu Chemicals, Incorporated | Dihydrocaffeic acid amide derivative and application thereof as medicine |
WO1992004054A1 (en) * | 1990-08-30 | 1992-03-19 | STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITY, PORTLAND, OREGON, and THE UNIVERSITY OF OREGON, EUGENE, OREGON, Johnson Hall, University of Oregon | Substituted amidines having high binding to the sigma receptor and the use thereof |
DE19921886A1 (en) * | 1999-05-12 | 2000-11-16 | Bayer Ag | New substituted N-cyano-amidine derivatives useful are herbicides useful as desiccants and defoliants and especially for weed control |
JP2004521878A (en) * | 2000-12-07 | 2004-07-22 | スィーヴィー セラピューティクス インコーポレイテッド | Compounds that increase ABCA-1 |
WO2004056744A1 (en) * | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
CN1227010C (en) * | 2003-04-22 | 2005-11-16 | 中国药科大学 | Usage of substituted tetrahydroisoquinoline derviation |
US7880001B2 (en) * | 2004-04-29 | 2011-02-01 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
CN101039908B (en) * | 2004-08-30 | 2010-06-23 | 詹森药业有限公司 | Tricyclic lactam derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
WO2006024627A2 (en) * | 2004-08-30 | 2006-03-09 | Janssen Pharmaceutica N.V. | N-2 adamantanyl-2-phenoxy-acetamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
CN101142172A (en) * | 2005-01-05 | 2008-03-12 | 艾博特公司 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
CN101137616A (en) * | 2005-01-05 | 2008-03-05 | 艾博特公司 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
ZA200800142B (en) * | 2005-06-08 | 2009-05-27 | Japan Tobacco Inc | Heterocyclic compound |
EP1801098A1 (en) * | 2005-12-16 | 2007-06-27 | Merck Sante | 2-Adamantylurea derivatives as selective 11B-HSD1 inhibitors |
EP1935420A1 (en) * | 2006-12-21 | 2008-06-25 | Merck Sante | 2-Adamantyl-butyramide derivatives as selective 11beta-HSD1 inhibitors |
JP2010526777A (en) * | 2007-04-24 | 2010-08-05 | ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー | Pharmaceutical use of substituted amides |
JP5736098B2 (en) * | 2007-08-21 | 2015-06-17 | アッヴィ・インコーポレイテッド | Pharmaceutical composition for treating central nervous system disorders |
JP5848698B2 (en) * | 2009-04-20 | 2016-01-27 | アッヴィ・インコーポレイテッド | Novel amide and amidine derivatives and their use |
-
2010
- 2010-04-20 JP JP2012507294A patent/JP5848698B2/en not_active Expired - Fee Related
- 2010-04-20 MX MX2011011082A patent/MX2011011082A/en active IP Right Grant
- 2010-04-20 WO PCT/US2010/031660 patent/WO2010123838A2/en active Application Filing
- 2010-04-20 CA CA2757866A patent/CA2757866A1/en not_active Abandoned
- 2010-04-20 CN CN201310652121.XA patent/CN103772239B/en not_active Expired - Fee Related
- 2010-04-20 CN CN201080026472.4A patent/CN102459158B/en not_active Expired - Fee Related
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2015
- 2015-08-27 JP JP2015167599A patent/JP2016026165A/en active Pending
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JP2016026165A (en) | 2016-02-12 |
JP2012524121A (en) | 2012-10-11 |
JP5848698B2 (en) | 2016-01-27 |
CN102459158A (en) | 2012-05-16 |
CN103772239A (en) | 2014-05-07 |
CN103772239B (en) | 2017-04-12 |
WO2010123838A2 (en) | 2010-10-28 |
CN102459158B (en) | 2015-11-25 |
CA2757866A1 (en) | 2010-10-28 |
WO2010123838A3 (en) | 2011-03-03 |
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