MX2011004161A - Generacion de imagenes y metodos de radioterapia. - Google Patents
Generacion de imagenes y metodos de radioterapia.Info
- Publication number
- MX2011004161A MX2011004161A MX2011004161A MX2011004161A MX2011004161A MX 2011004161 A MX2011004161 A MX 2011004161A MX 2011004161 A MX2011004161 A MX 2011004161A MX 2011004161 A MX2011004161 A MX 2011004161A MX 2011004161 A MX2011004161 A MX 2011004161A
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- 6alkyl
- compound
- fluoro
- iodine
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 82
- 238000001959 radiotherapy Methods 0.000 title claims description 19
- 238000003384 imaging method Methods 0.000 title description 5
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- 229910052740 iodine Inorganic materials 0.000 claims description 35
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 31
- 239000011630 iodine Substances 0.000 claims description 31
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- 239000000758 substrate Substances 0.000 claims description 28
- 239000012453 solvate Substances 0.000 claims description 27
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- 210000000130 stem cell Anatomy 0.000 claims description 23
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 19
- 125000005843 halogen group Chemical group 0.000 claims description 18
- 239000001257 hydrogen Substances 0.000 claims description 18
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 18
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 17
- 125000001424 substituent group Chemical group 0.000 claims description 17
- 125000000217 alkyl group Chemical group 0.000 claims description 16
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 16
- 238000001727 in vivo Methods 0.000 claims description 16
- 229910052757 nitrogen Inorganic materials 0.000 claims description 16
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- 229910052751 metal Inorganic materials 0.000 claims description 15
- 239000002184 metal Substances 0.000 claims description 15
- 125000002346 iodo group Chemical group I* 0.000 claims description 14
- 125000003118 aryl group Chemical group 0.000 claims description 12
- 125000001153 fluoro group Chemical group F* 0.000 claims description 11
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 10
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- 239000001301 oxygen Chemical group 0.000 claims description 10
- 229910052760 oxygen Inorganic materials 0.000 claims description 10
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- 230000000694 effects Effects 0.000 claims description 9
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- 229910052717 sulfur Inorganic materials 0.000 claims description 9
- 239000011593 sulfur Chemical group 0.000 claims description 9
- 125000003545 alkoxy group Chemical group 0.000 claims description 8
- 229910052796 boron Chemical group 0.000 claims description 8
- 238000001514 detection method Methods 0.000 claims description 7
- 125000005842 heteroatom Chemical group 0.000 claims description 7
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 7
- 229910052755 nonmetal Inorganic materials 0.000 claims description 7
- 238000002603 single-photon emission computed tomography Methods 0.000 claims description 7
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims description 5
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- 239000003814 drug Substances 0.000 claims description 3
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical group [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims description 2
- 125000001041 indolyl group Chemical group 0.000 claims description 2
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- UUZZMWZGAZGXSF-UHFFFAOYSA-N peroxynitric acid Chemical compound OON(=O)=O UUZZMWZGAZGXSF-UHFFFAOYSA-N 0.000 claims 1
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- 238000011503 in vivo imaging Methods 0.000 abstract description 3
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 10
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- 229910052794 bromium Inorganic materials 0.000 description 8
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- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 6
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- 231100000419 toxicity Toxicity 0.000 description 1
- 238000006478 transmetalation reaction Methods 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 208000010570 urinary bladder carcinoma Diseases 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Radiology & Medical Imaging (AREA)
- Medical Informatics (AREA)
- Organic Chemistry (AREA)
- Surgery (AREA)
- High Energy & Nuclear Physics (AREA)
- General Chemical & Material Sciences (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Radiation-Therapy Devices (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10700108P | 2008-10-21 | 2008-10-21 | |
| GBGB0819280.9A GB0819280D0 (en) | 2008-10-21 | 2008-10-21 | Imgaing and radiotherapy methods |
| PCT/US2009/061271 WO2010048144A2 (en) | 2008-10-21 | 2009-10-20 | Imaging and radiotherapy methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011004161A true MX2011004161A (es) | 2011-06-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011004161A MX2011004161A (es) | 2008-10-21 | 2009-10-20 | Generacion de imagenes y metodos de radioterapia. |
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| Country | Link |
|---|---|
| US (1) | US20110286922A1 (enExample) |
| EP (1) | EP2349351A2 (enExample) |
| JP (1) | JP2012506439A (enExample) |
| KR (1) | KR20110074988A (enExample) |
| CN (1) | CN102186505A (enExample) |
| AU (1) | AU2009307783A1 (enExample) |
| BR (1) | BRPI0919690A2 (enExample) |
| CA (1) | CA2738955A1 (enExample) |
| GB (1) | GB0819280D0 (enExample) |
| MX (1) | MX2011004161A (enExample) |
| RU (1) | RU2011113996A (enExample) |
| WO (1) | WO2010048144A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8540968B2 (en) | 2004-03-02 | 2013-09-24 | Cellectar, Inc. | Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof |
| AU2005219412A1 (en) | 2004-03-02 | 2005-09-15 | Cellectar, Inc. | Phospholipid analogs for diagnosis and treatment of cancer |
| CU23844B1 (es) * | 2009-04-17 | 2012-10-15 | Ct De Neurociencias De Cuba | Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer |
| DK3708192T3 (da) * | 2009-06-12 | 2023-11-06 | Cellectar Inc | Etherphospholipidforbindelser til behandling af cancer og billeddannelse og detektering af cancerstamceller |
| US20120251449A1 (en) * | 2009-12-22 | 2012-10-04 | Vijaya Raj Kuniyil Kulangara | Aldh: a compound for cancer stem cell imaging |
| US9649394B2 (en) | 2010-11-22 | 2017-05-16 | The General Hospital Corporation | Compositions and methods for in vivo imaging |
| US9987380B2 (en) | 2011-07-15 | 2018-06-05 | University Of Southern California | Boron-based dual imaging probes, compositions and methods for rapid aqueous F-18 labeling, and imaging methods using same |
| WO2013048832A1 (en) * | 2011-09-29 | 2013-04-04 | Ge Healthcare Limited | 18 f - labelled 6 - ( 2 - fluoroethoxy) - 2 - naphthaldehyde for detecting cancer stem cells |
| WO2013048811A1 (en) * | 2011-09-30 | 2013-04-04 | Ge Healthcare Limited | Imaging and radiotherapy methods for tumour stem cells |
| US8927732B2 (en) * | 2012-03-30 | 2015-01-06 | General Electric Company | Biotin stannane for HPLC-free radioiodination |
| WO2014145493A1 (en) * | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Radioactive substrates for aldehyde dehydrogenase |
| EP3450963A4 (en) * | 2016-04-28 | 2020-01-29 | National University Corporation Nagoya University | FLUORESCENT PROBE, METHOD FOR DETECTING FLUORESCENCE AND METHOD OF USING FLUORESCENT PROBE |
| FR3054564B1 (fr) * | 2016-07-28 | 2018-08-31 | Advanced Biodesign | Substrat specifique d'une isoenzyme de l'aldh |
| KR101941223B1 (ko) * | 2017-04-04 | 2019-01-22 | 을지대학교 산학협력단 | 복강경 수술용 삼중 융합영상장치 |
| JP2023025307A (ja) * | 2020-01-31 | 2023-02-22 | 国立大学法人 東京大学 | アルデヒドロゲナーゼ１ａ１検出用青色蛍光プローブ |
Family Cites Families (6)
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| US5876956A (en) * | 1995-05-15 | 1999-03-02 | Johns Hopkins University School Of Medicine | Methods for identification or purification of cells containing an enzymatic intracellular marker |
| US20040009956A1 (en) * | 2002-04-29 | 2004-01-15 | Dehua Pei | Inhibition of protein tyrosine phosphatases and SH2 domains by a neutral phosphotyrosine mimetic |
| GB0305704D0 (en) * | 2003-03-13 | 2003-04-16 | Amersham Plc | Radiofluorination methods |
| GB0502277D0 (en) * | 2005-02-04 | 2005-03-09 | Amersham Plc | Novel imaging agents |
| CA2644136A1 (en) * | 2006-02-27 | 2007-09-07 | The Johns Hopkins University | Cancer treatment with gamma-secretase inhibitors |
| WO2008036419A2 (en) * | 2006-09-22 | 2008-03-27 | The Regents Of The University Of Michigan | Aldehyde dehydrogenase 1(aldh1) as a cancer stem cell marker |
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2008
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2009
- 2009-10-20 AU AU2009307783A patent/AU2009307783A1/en not_active Abandoned
- 2009-10-20 JP JP2011533266A patent/JP2012506439A/ja active Pending
- 2009-10-20 BR BRPI0919690A patent/BRPI0919690A2/pt not_active IP Right Cessation
- 2009-10-20 MX MX2011004161A patent/MX2011004161A/es not_active Application Discontinuation
- 2009-10-20 RU RU2011113996/15A patent/RU2011113996A/ru not_active Application Discontinuation
- 2009-10-20 US US13/124,703 patent/US20110286922A1/en not_active Abandoned
- 2009-10-20 WO PCT/US2009/061271 patent/WO2010048144A2/en not_active Ceased
- 2009-10-20 EP EP09749242A patent/EP2349351A2/en not_active Withdrawn
- 2009-10-20 CN CN2009801423890A patent/CN102186505A/zh active Pending
- 2009-10-20 CA CA2738955A patent/CA2738955A1/en not_active Abandoned
- 2009-10-20 KR KR1020117008974A patent/KR20110074988A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN102186505A (zh) | 2011-09-14 |
| US20110286922A1 (en) | 2011-11-24 |
| BRPI0919690A2 (pt) | 2015-12-08 |
| AU2009307783A1 (en) | 2010-04-29 |
| RU2011113996A (ru) | 2012-11-27 |
| JP2012506439A (ja) | 2012-03-15 |
| WO2010048144A2 (en) | 2010-04-29 |
| WO2010048144A3 (en) | 2010-07-22 |
| GB0819280D0 (en) | 2008-11-26 |
| CA2738955A1 (en) | 2010-04-29 |
| EP2349351A2 (en) | 2011-08-03 |
| KR20110074988A (ko) | 2011-07-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |