MX2010004300A - Ligandos de (1,4-diaza-biciclo [3,2,2]non-6-en-4-il)-heterociclil- metanona para receptores nicotinicos de acetilcolina, utiles para el tratamiento de enfermedad. - Google Patents

Ligandos de (1,4-diaza-biciclo [3,2,2]non-6-en-4-il)-heterociclil- metanona para receptores nicotinicos de acetilcolina, utiles para el tratamiento de enfermedad.

Info

Publication number
MX2010004300A
MX2010004300A MX2010004300A MX2010004300A MX2010004300A MX 2010004300 A MX2010004300 A MX 2010004300A MX 2010004300 A MX2010004300 A MX 2010004300A MX 2010004300 A MX2010004300 A MX 2010004300A MX 2010004300 A MX2010004300 A MX 2010004300A
Authority
MX
Mexico
Prior art keywords
ligands
nicotinic acetylcholine
treatment
acetylcholine receptors
disease
Prior art date
Application number
MX2010004300A
Other languages
English (en)
Inventor
Richard Schumacher
Brian Herbert
Wenge Xie
Guangxiu Dai
Original Assignee
Memory Pharm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memory Pharm Corp filed Critical Memory Pharm Corp
Publication of MX2010004300A publication Critical patent/MX2010004300A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/24—Antidepressants
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    • A61P25/32—Alcohol-abuse
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

La presente invención se refiere en general al campo de ligandos para receptores nicotínicos de acetilcolina (receptores nACh), a la activación de receptores nACh, y al tratamiento de condiciones de enfermedad asociadas con receptores nicotínicos de acetilcolina, que son defectuosos o de mal funcionamiento, especialmente del cerebro. Adicionalmente, esta invención se refiere a nuevos compuestos, que actúan como ligandos para el subtipo a7 de receptor nACh, métodos para preparar estos compuestos, composiciones que contienen estos compuestos, y a métodos útiles de los mismos. Los nuevos compuestos incluyen compuestos de la formula I: (I) en donde X, R1 y R2 son como se definen en la presente. (Ver fórmula (I)).
MX2010004300A 2007-10-22 2008-10-22 Ligandos de (1,4-diaza-biciclo [3,2,2]non-6-en-4-il)-heterociclil- metanona para receptores nicotinicos de acetilcolina, utiles para el tratamiento de enfermedad. MX2010004300A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98164307P 2007-10-22 2007-10-22
US5036608P 2008-05-05 2008-05-05
PCT/US2008/080743 WO2009055437A2 (en) 2007-10-22 2008-10-22 (1,4-diaza-bicyclo[3.2.2]non-6-en-4-yl)-heterocyclyl-methanone ligands for nicotinic acetylcholine receptors, useful for the treatment of disease

Publications (1)

Publication Number Publication Date
MX2010004300A true MX2010004300A (es) 2010-06-17

Family

ID=40580357

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010004300A MX2010004300A (es) 2007-10-22 2008-10-22 Ligandos de (1,4-diaza-biciclo [3,2,2]non-6-en-4-il)-heterociclil- metanona para receptores nicotinicos de acetilcolina, utiles para el tratamiento de enfermedad.

Country Status (10)

Country Link
US (1) US20100298306A1 (es)
EP (1) EP2212321A4 (es)
JP (1) JP2011500728A (es)
KR (1) KR20100087172A (es)
CN (1) CN101910170A (es)
AU (1) AU2008316895A1 (es)
CA (1) CA2703163A1 (es)
IL (1) IL205156A0 (es)
MX (1) MX2010004300A (es)
WO (1) WO2009055437A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006021954A2 (en) 2004-08-23 2006-03-02 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Peptide inhibitors for mediating stress responses
EP3263127B1 (en) 2011-05-23 2019-08-21 Yeda Research and Development Co. Ltd Use of akt phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
CA2912921C (en) * 2013-06-24 2021-05-18 Merck Patent Gmbh Pyrazole compounds as modulators of fshr and uses thereof
JP6526956B2 (ja) * 2013-12-19 2019-06-05 花王株式会社 固形状組成物
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
EP3759109B1 (en) 2018-02-26 2023-08-30 Gilead Sciences, Inc. Substituted pyrrolizine compounds as hbv replication inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0202430D0 (sv) * 2002-08-14 2002-08-14 Astrazeneca Ab New Compounds
FR2845388B1 (fr) * 2002-10-08 2004-11-12 Sanofi Synthelabo Derives de 1,4-diazabicyclo[3.2.2]nonanecarboxamides, leur preparation et leur application en therapeutique
US7456171B2 (en) * 2002-10-08 2008-11-25 Sanofi-Aventis 1,4-Diazabicyclo[3.2.2]nonanecarboxamide derivatives, preparation and therapeutic use thereof
AU2005243147A1 (en) * 2004-05-07 2005-11-24 Memory Pharmaceuticals Corporation 1H-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof
KR20080067339A (ko) * 2005-11-09 2008-07-18 메모리 파마슈티칼스 코포레이션 1ｈ-인다졸, 벤조티아졸, 1,2-벤조이속사졸,1,2-벤조이소티아졸, 및 크로몬 및 그들의 제조법 및 용도
US8541406B2 (en) * 2006-02-07 2013-09-24 Nv Remynd Thiadiazole derivatives for the treatment of neurodegenerative diseases

Also Published As

Publication number Publication date
WO2009055437A3 (en) 2009-06-11
EP2212321A4 (en) 2011-03-23
JP2011500728A (ja) 2011-01-06
WO2009055437A9 (en) 2009-07-23
CA2703163A1 (en) 2009-04-30
WO2009055437A2 (en) 2009-04-30
US20100298306A1 (en) 2010-11-25
AU2008316895A1 (en) 2009-04-30
EP2212321A2 (en) 2010-08-04
IL205156A0 (en) 2010-11-30
KR20100087172A (ko) 2010-08-03
CN101910170A (zh) 2010-12-08

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