MX2010002316A - Tetracyclic indole derivatives and their use for treating or preventing viral infections. - Google Patents

Tetracyclic indole derivatives and their use for treating or preventing viral infections.

Info

Publication number
MX2010002316A
MX2010002316A MX2010002316A MX2010002316A MX2010002316A MX 2010002316 A MX2010002316 A MX 2010002316A MX 2010002316 A MX2010002316 A MX 2010002316A MX 2010002316 A MX2010002316 A MX 2010002316A MX 2010002316 A MX2010002316 A MX 2010002316A
Authority
MX
Mexico
Prior art keywords
treating
indole derivatives
tetracyclic indole
viral infections
preventing viral
Prior art date
Application number
MX2010002316A
Other languages
Spanish (es)
Inventor
Frank Bennett
Srikanth Venkatraman
Joseph A Kozlowski
F George Njoroge
Mousumi Sannigrahi
Kevin X Chen
Stuart B Rosenblum
Qingbei Zeng
Gopinadhan N Anilkumar
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX2010002316A publication Critical patent/MX2010002316A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to Tetracyclic Indole Derivatives, compositions comprising at least one Tetracyclic Indole Derivative, and methods of using the Tetracyclic Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
MX2010002316A 2007-08-29 2008-08-27 Tetracyclic indole derivatives and their use for treating or preventing viral infections. MX2010002316A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96868407P 2007-08-29 2007-08-29
PCT/US2008/010147 WO2009032123A2 (en) 2007-08-29 2008-08-27 Tetracyclic indole derivatives and their use for treating or preventing viral infections

Publications (1)

Publication Number Publication Date
MX2010002316A true MX2010002316A (en) 2010-03-22

Family

ID=40319417

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010002316A MX2010002316A (en) 2007-08-29 2008-08-27 Tetracyclic indole derivatives and their use for treating or preventing viral infections.

Country Status (11)

Country Link
EP (1) EP2197884A2 (en)
JP (1) JP5179585B2 (en)
KR (1) KR20100061819A (en)
CN (1) CN101842376A (en)
AR (1) AR068109A1 (en)
AU (1) AU2008295483B2 (en)
CA (1) CA2697451A1 (en)
MX (1) MX2010002316A (en)
TW (1) TW200918536A (en)
WO (1) WO2009032123A2 (en)
ZA (1) ZA201001391B (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5501251B2 (en) 2008-01-11 2014-05-21 アルバニー モレキュラー リサーチ， インコーポレイテッド (1-Azinone) substituted pyridoindoles as MCH antagonists
JP5580814B2 (en) * 2008-06-13 2014-08-27 メルク・シャープ・アンド・ドーム・コーポレーション Tricyclic indole derivatives and methods of use thereof
ES2383273T3 (en) 2008-07-23 2012-06-19 F. Hoffmann-La Roche Ag Heterocyclic Antiviral Compounds
JP2012503620A (en) 2008-09-26 2012-02-09 エフ．ホフマン−ラ ロシュ アーゲー Pyrin or pyrazine derivatives for treating HCV
AU2010240888A1 (en) 2009-04-25 2011-11-17 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
AU2010253791A1 (en) 2009-05-29 2011-11-24 Merck Sharp & Dohme Corp. Antiviral compounds composed of three linked Aryl moieties to treat diseases such as Hepatitis C
TWI428332B (en) 2009-06-09 2014-03-01 Hoffmann La Roche Heterocyclic antiviral compounds
CA2762675A1 (en) 2009-06-24 2010-12-29 F. Hoffmann-La Roche Ag Heterocyclic antiviral compound
EP2448585B1 (en) 2009-07-01 2014-01-01 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof
WO2011003007A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
WO2011003012A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
US9073925B2 (en) 2009-07-01 2015-07-07 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
JP2013505218A (en) 2009-09-21 2013-02-14 エフ．ホフマン−ラ ロシュ アーゲー Heterocyclic antiviral compounds
AU2010324871A1 (en) 2009-11-25 2012-06-14 Merck Sharp & Dohme Corp. Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases
AU2010341537A1 (en) 2009-12-22 2012-08-09 Merck Sharp & Dohme Corp. Fused Tricyclic Compounds and methods of use thereof for the treatment of viral diseases
SG183526A1 (en) 2010-03-09 2012-09-27 Merck Sharp & Dohme Fused tricyclic silyl compounds and methods of use thereof for the treatment of viral diseases
EP2566697B1 (en) 2010-05-02 2020-12-09 Xjet Ltd. Printing system with self-purge, sediment prevention and fumes removal arrangements
JP2013541499A (en) 2010-07-26 2013-11-14 メルク・シャープ・エンド・ドーム・コーポレイション Substituted biphenylene compounds and methods of use thereof for the treatment of viral diseases
EP2621932A4 (en) * 2010-09-29 2014-03-26 Merck Sharp & Dohme Tetracyclic heterocycle compounds for treating hepatitis c viral infection
AU2011314168A1 (en) 2010-09-29 2013-04-04 Merck Sharp & Dohme Corp. Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases
US8993765B2 (en) 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
US8697700B2 (en) 2010-12-21 2014-04-15 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof
US9156872B2 (en) 2011-04-13 2015-10-13 Merck Sharp & Dohme Corp. 2′-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
BR112013026345A2 (en) 2011-04-13 2019-04-24 Merck Sharp & Dohe Corp. compound, pharmaceutical composition, use of a compound, and method for treating an hcv infected patient
WO2013033899A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
WO2013033901A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases
WO2013033900A1 (en) * 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases
EP2755981A4 (en) 2011-09-14 2015-03-25 Merck Sharp & Dohme Silyl-containing heterocyclic compounds and methods of use thereof for the treatment of viral diseases
AR092959A1 (en) 2012-10-17 2015-05-06 Merck Sharp & Dohme DERIVATIVES OF NUCLEOSIDS 2-METHYL SUBSTITUTED AND METHODS OF USE OF THE SAME FOR THE TREATMENT OF VIRAL DISEASES
US9242988B2 (en) 2012-10-17 2016-01-26 Merck Sharp & Dohme Corp. 2′-cyano substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
EP2909210A4 (en) 2012-10-17 2016-04-06 Merck Sharp & Dohme 2'-disubstituted substituted nucleoside derivatives and methods of use thereof for treatment of viral diseases
RU2015123641A (en) 2012-11-19 2017-01-10 Мерк Шарп И Доум Корп. 2-ALKINYL SUBSTITUTED NUCLEOSIDE DERIVATIVES FOR THE TREATMENT OF VIRAL DISEASES
US9765107B2 (en) 2013-06-18 2017-09-19 Merck Sharp & Dohme Corp. Cyclic phosphonate substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
WO2014205592A1 (en) 2013-06-24 2014-12-31 Merck Sharp & Dohme Corp. Heterocyclic compounds and methods of use thereof for treatment of hepatitis c
WO2014205593A1 (en) 2013-06-24 2014-12-31 Merck Sharp & Dohme Corp. Substituted benzofuran compounds and methods of use thereof for treatment of viral diseases
WO2015065817A1 (en) 2013-10-30 2015-05-07 Merck Sharp & Dohme Corp. Pseudopolymorphs of an hcv ns5a inhibitor and uses thereof
US10899788B2 (en) 2016-06-20 2021-01-26 Merck Sharp & Dohme Corp. Cyclic phosphate substituted nucleoside compounds and methods of use thereof for the treatment of viral diseases
CN112898312B (en) * 2021-01-29 2021-11-12 湖南南新制药股份有限公司 Fused polycyclic pyridone derivative and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7153848B2 (en) * 2004-08-09 2006-12-26 Bristol-Myers Squibb Company Inhibitors of HCV replication
JP2008514611A (en) * 2004-09-23 2008-05-08 ワイス Derivatives of carbazole and cyclopentaindole for treating infection with hepatitis C virus
GB0518390D0 (en) * 2005-09-09 2005-10-19 Angeletti P Ist Richerche Bio Therapeutic compounds
CA2623026A1 (en) * 2005-09-23 2007-04-05 Schering Corporation Fused tetracyclic mglur1 antagonists as therapeutic agents

Also Published As

Publication number Publication date
EP2197884A2 (en) 2010-06-23
AU2008295483A1 (en) 2009-03-12
CA2697451A1 (en) 2009-03-12
JP5179585B2 (en) 2013-04-10
JP2010537980A (en) 2010-12-09
ZA201001391B (en) 2010-11-24
KR20100061819A (en) 2010-06-09
TW200918536A (en) 2009-05-01
AR068109A1 (en) 2009-11-04
AU2008295483B2 (en) 2013-11-21
WO2009032123A2 (en) 2009-03-12
CN101842376A (en) 2010-09-22
WO2009032123A3 (en) 2009-06-11

Similar Documents

Publication Publication Date Title
MX2010002316A (en) Tetracyclic indole derivatives and their use for treating or preventing viral infections.
MX2010002317A (en) Substituted indole derivatives and methods of use thereof.
MX2010005356A (en) 3-heterocyclic substituted indole derivatives and methods of use thereof.
MX2010002319A (en) 2, 3-substituted indole derivatives for treating viral infections.
MX2010005355A (en) 3-aminosulfonyl substituted indole derivatives and methods of use thereof.
MX2010002318A (en) 2,3-substituted azaindole derivatives for treating viral infections.
TW200833684A (en) 5,6-ring annulated indole derivatives and methods of use thereof
TW200833662A (en) 4,5-ring annulated indole derivatives and methods of use thereof
MX2009011533A (en) Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases.
MX2012011222A (en) Compounds and pharmaceutical compositions for the treatment of viral infections.
CL2012001176A1 (en) Benzimidazole-imidazole derivative compounds, hepatitis c virus (hcv) inhibitors; pharmaceutical composition comprising them; pharmaceutical combination; use in the prevention or treatment of hcv infection.
MX2009009473A (en) Compounds for the treatment of hepatitis c.
TN2013000421A1 (en) 2'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
MX2013003634A (en) Polycyclic heterocycle derivatives and methods of use thereof for the treatment of viral diseases.
WO2008127364A3 (en) Antiviral compounds and use thereof
ECSP099447A (en) INDÓLIC DERIVATIVES WITH UNITED RING IN POSITIONS 4,5 AND THEIR METHODS OF USE
MA33806B1 (en) INHIBITORS OF HEPATITIS C VIRUS
NO20064547L (en) Methods for treating HIV infection
WO2009149179A3 (en) Enhanced antiviral therapy methods and devices
WO2008115281A3 (en) Compounds for treating viral infections
MX2009013828A (en) Therapeutic compositions and the use thereof.
MX2010006206A (en) 5-halogen-substituted oxindole derivatives and use thereof for treating vasopressine-dependent diseases.
MY149705A (en) Pyridino-pyridinone derivatives, preparation therof, and therapeutic use thereof
MX2008013196A (en) 5-amido-2-carboxamide indoles.
WO2011160024A3 (en) Compounds useful as antiviral agents, compositions, and methods of use

Legal Events

Date Code Title Description
HH Correction or change in general
FA Abandonment or withdrawal