MX2009012612A - Purinones and 1h-imidazopyridinones as pkc-theta inhibitors. - Google Patents

Purinones and 1h-imidazopyridinones as pkc-theta inhibitors.

Info

Publication number
MX2009012612A
MX2009012612A MX2009012612A MX2009012612A MX2009012612A MX 2009012612 A MX2009012612 A MX 2009012612A MX 2009012612 A MX2009012612 A MX 2009012612A MX 2009012612 A MX2009012612 A MX 2009012612A MX 2009012612 A MX2009012612 A MX 2009012612A
Authority
MX
Mexico
Prior art keywords
imidazopyridinones
purinones
pkc
theta inhibitors
inhibitors
Prior art date
Application number
MX2009012612A
Other languages
Spanish (es)
Inventor
David Diller
Andrew Roughten
Yajing Rong
Koc Kan Ho
Michael Ohlmeyer
Original Assignee
Pharmacopeia Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacopeia Llc filed Critical Pharmacopeia Llc
Publication of MX2009012612A publication Critical patent/MX2009012612A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

A chemical genus of purinones and 1H-imidazopyridinones, which are useful as PKCΘ inhibitors, and their methods of use are disclosed. The genus is represented by the formula (I). A representative example is: (II).
MX2009012612A 2007-05-23 2007-05-23 Purinones and 1h-imidazopyridinones as pkc-theta inhibitors. MX2009012612A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2007/069530 WO2008143674A1 (en) 2007-05-23 2007-05-23 Purinones and 1h-imidazopyridinones as pkc-theta inhibitors

Publications (1)

Publication Number Publication Date
MX2009012612A true MX2009012612A (en) 2009-12-07

Family

ID=39262569

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009012612A MX2009012612A (en) 2007-05-23 2007-05-23 Purinones and 1h-imidazopyridinones as pkc-theta inhibitors.

Country Status (6)

Country Link
EP (1) EP2152708A1 (en)
JP (1) JP2010527999A (en)
CN (1) CN101679412A (en)
CA (1) CA2686485A1 (en)
MX (1) MX2009012612A (en)
WO (1) WO2008143674A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7989459B2 (en) * 2006-02-17 2011-08-02 Pharmacopeia, Llc Purinones and 1H-imidazopyridinones as PKC-theta inhibitors
AR063141A1 (en) 2006-10-04 2008-12-30 Pharmacopeia Inc DERIVATIVES OF 2- (BENZIMIDAZOLIL) PURINA 8- REPLACED FOR IMMUNOSUPPRESSION
CL2007002866A1 (en) 2006-10-04 2008-07-04 Pharmacopeia Inc COMPOUNDS DERIVED FROM 6-SUBSTITUTES-2- (BENCIMIDAZOLIL) PURINA AND PURINONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUND; AND USE OF THE COMPOUND IN THE TREATMENT OF AUTOIMMUNE DISEASES, INFLAMMATORY DISEASE, DISEASE MEDIATED BY M
US7902187B2 (en) 2006-10-04 2011-03-08 Wyeth Llc 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
WO2009062059A2 (en) * 2007-11-08 2009-05-14 Pharmacopeia, Inc. Isomeric purinones and 1h-imidazopyridinones as pkc-theta inhibitors
PA8851101A1 (en) 2008-12-16 2010-07-27 Lilly Co Eli AMINO PIRAZOL COMPOUND
DK2493895T3 (en) 2009-10-29 2017-08-14 Vectura Ltd N-CONTRIBUTING HETEROYEER DERIVATIVES AS JAK3 KINase INHIBITORS
GB201321737D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
MX2018005925A (en) 2015-11-20 2019-03-28 Forma Therapeutics Inc Purinones as ubiquitin-specific protease 1 inhibitors.
EP3808747A4 (en) * 2018-09-13 2022-03-09 Kissei Pharmaceutical Co., Ltd. Imidazopyridinone compound
CN114728969B (en) * 2019-11-25 2024-03-08 再鼎医药(上海)有限公司 Pyrimidoimidazoles as DNA-PK inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1390220A (en) 1999-09-17 2003-01-08 艾博特股份有限两合公司 Kinase inhibitors as therapeutic agents
BRPI0608160A2 (en) * 2005-02-16 2010-11-09 Astrazeneca Ab isolated antibody, host cell, method of inhibiting psma + cell growth, and use of a defucosylated anti-psma antibody
RU2007140903A (en) * 2005-04-05 2009-05-20 Фармакопия, Инк. (Us) PURINE AND IMIDAZOPYRIDINE DERIVATIVES FOR IMMUNOSUPRESSION
DE102005042742A1 (en) 2005-09-02 2007-03-08 Schering Ag Substituted imidazo [1,2b] pyridazines as kinase inhibitors, their production and use as pharmaceuticals
US20090023723A1 (en) * 2005-09-21 2009-01-22 Pharmacopeia Drug Discovery, Inc. Purinone derivatives for treating neurodegenerative diseases

Also Published As

Publication number Publication date
CN101679412A (en) 2010-03-24
CA2686485A1 (en) 2008-11-27
EP2152708A1 (en) 2010-02-17
JP2010527999A (en) 2010-08-19
WO2008143674A1 (en) 2008-11-27

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