MX2009003324A - Immune modulators, preparations and compositions including immune modulators, tests for evaluating the activity of immune modulators and preparations and compositions including the same, and methods. - Google Patents

Immune modulators, preparations and compositions including immune modulators, tests for evaluating the activity of immune modulators and preparations and compositions including the same, and methods.

Info

Publication number
MX2009003324A
MX2009003324A MX2009003324A MX2009003324A MX2009003324A MX 2009003324 A MX2009003324 A MX 2009003324A MX 2009003324 A MX2009003324 A MX 2009003324A MX 2009003324 A MX2009003324 A MX 2009003324A MX 2009003324 A MX2009003324 A MX 2009003324A
Authority
MX
Mexico
Prior art keywords
immune modulators
preparations
compositions
compositions including
immune
Prior art date
Application number
MX2009003324A
Other languages
Spanish (es)
Inventor
Calvin W Mccausland
David Lisonbee
Richard H Bennett
Brent M Vaughan
Shane M Lefler
Original Assignee
4Life Res Lc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4Life Res Lc filed Critical 4Life Res Lc
Publication of MX2009003324A publication Critical patent/MX2009003324A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20—Milk; Whey; Colostrum
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70514—CD4

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)

Abstract

Compositions that include extracts from sources of immune modulators that include nanofraction immune modulator molecules (i.e., molecules having molecular weights of about 3,000 Da and less) are disclosed. These compositions may also include other immune modulators, such as transfer factor. Administration of compositions with extracts that include nanofraction immune modulator molecules modulates the cell mediated immunity (e.g., down regulates undesired T cell activity) of a subject to which such compositions are administered. When administered with transfer factor, the combination of nanofraction immune modulator molecules and transfer factor down regulates undesired T cell activity while increasing, or up regulating, T cell activity against pathogens and other undesirable entities, such as cancer cells and other aberrant or mutated cells. Assays and assay techniques for evaluating the immune modulation capabilities of various substances are also disclosed.
MX2009003324A 2006-09-29 2007-09-19 Immune modulators, preparations and compositions including immune modulators, tests for evaluating the activity of immune modulators and preparations and compositions including the same, and methods. MX2009003324A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84834806P 2006-09-29 2006-09-29
US11/855,944 US10471100B2 (en) 2006-09-29 2007-09-14 Nanofraction immune modulators, preparations and compositions including the same, and associated methods
PCT/US2007/078947 WO2008042604A2 (en) 2006-09-29 2007-09-19 Immune modulators, preparations and compositions including immune modulators, tests for evaluating the activity of immune modulators and preparations and compositions including the same, and methods

Publications (1)

Publication Number Publication Date
MX2009003324A true MX2009003324A (en) 2009-06-30

Family

ID=39261440

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009003324A MX2009003324A (en) 2006-09-29 2007-09-19 Immune modulators, preparations and compositions including immune modulators, tests for evaluating the activity of immune modulators and preparations and compositions including the same, and methods.

Country Status (15)

Country Link
US (2) US10471100B2 (en)
EP (1) EP2068913B1 (en)
JP (3) JP5592651B2 (en)
CN (1) CN101553247B (en)
AU (1) AU2007305076B2 (en)
CO (1) CO6220833A2 (en)
EC (1) ECSP099296A (en)
ES (1) ES2658107T3 (en)
HK (1) HK1138181A1 (en)
MX (1) MX2009003324A (en)
MY (2) MY158857A (en)
RU (2) RU2518341C2 (en)
SG (1) SG160430A1 (en)
TW (1) TWI449530B (en)
WO (1) WO2008042604A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6866868B1 (en) * 2003-09-15 2005-03-15 4Life Research, Lc Compositions including different types of transfer factor, methods for making the compositions, and methods of treatment using the compositions
US9028882B2 (en) 2005-05-02 2015-05-12 4Life Patents, Llc Nutraceutical gels
WO2006119408A1 (en) * 2005-05-02 2006-11-09 4Life Patents, Llc Transfer factor preparations and associated methods
US10471100B2 (en) * 2006-09-29 2019-11-12 4Life Patents, Llc Nanofraction immune modulators, preparations and compositions including the same, and associated methods
TW201105966A (en) * 2009-05-05 2011-02-16 4Life Patents Llc Methods and systems for assaying, maintaining, and enhancing the activity of the immune system of a subject
DK2643017T3 (en) 2010-11-23 2019-08-26 Pantheryx Inc Compositions and methods of treatment in undifferentiated or mixed broad-spectrum clinical applications
CN102172360B (en) * 2011-02-17 2013-04-24 南京大学 Colostrum extract and extraction method and application thereof
WO2013039373A2 (en) * 2011-09-13 2013-03-21 Zepeda Lopez Hector Manuel Dialysed extract of leucocytes from shark spleen, for obtaining a transfer factor with increased potential, and method for extracting, checking and counting same
WO2013039374A2 (en) * 2011-09-15 2013-03-21 Zepeda Lopez Hector Manuel Method for extracting, testing and counting dialysed leukocyte extract from shark spleen in order to obtain an enhanced transfer factor, specifically designed to be used as a treatment against the disease known as vitiligo
WO2013043033A2 (en) * 2011-09-19 2013-03-28 Zepeda Lopez Hector Manuel Method for extracting and checking a dialysed extract of leukocytes from shark spleen, in order to obtain a transfer factor with increased potential, specifically designed to be used as an adjuvant for increasing the potential of viral vaccines
WO2013043032A2 (en) * 2011-09-19 2013-03-28 Zepeda Lopez Hector Manuel Dialysed extract of leucocytes from shark spleen, for obtaining a transfer factor with increased potential, specifically designed to be used as an immunomodulator, and method for extracting, checking and counting same
WO2013058640A2 (en) * 2011-10-20 2013-04-25 Zepeda Lopez Hector Manuel Method for the extraction, verification and counting of dialyzed leukocyte extract originating from shark spleen in order to obtain potentialized transfer factor, specifically designed for use as treatment against the disease known as asthma
MX338863B (en) * 2011-12-16 2016-05-01 Inst Politecnico Nacional Method for obtaining a dialyzable leukocyte extract.
US9566305B2 (en) * 2013-10-13 2017-02-14 4Life Patents, Llc Therapeutic compositions and methods for addressing physiological stresses and aging
KR101597540B1 (en) * 2014-01-22 2016-02-29 건국대학교 산학협력단 Composition comprising egg yolk extract for immune activity
JP7352539B2 (en) * 2017-06-15 2023-09-28 ミラディーエックス Biomarkers to predict tumor response to immunotherapy and its toxicity
US10933097B1 (en) 2020-03-05 2021-03-02 King Saud University Method of treating a bacterial infection using colostrum

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4402938A (en) * 1980-05-29 1983-09-06 Impro Products, Inc. Food and the method of extracting the same from colostrum and milk
US4816563A (en) 1983-11-25 1989-03-28 Amtron, Inc. Process for obtaining transfer factor from colostrum, transfer factor so obtained and use thereof
JPS60208919A (en) * 1983-11-25 1985-10-21 アムトロン・インコ−ポレイテツド Method of obtaining transfer factor from first milk, transfer factor and use
US5585098A (en) 1993-11-23 1996-12-17 Ovimmune, Inc. Oral administration of chicken yolk immunoglobulins to lower somatic cell count in the milk of lactating ruminants
AU724703B2 (en) 1996-03-26 2000-09-28 Cylex, Inc. Methods for measurement of lymphocyte function
CA2249448C (en) 1996-03-26 2003-10-28 Dcv Biologics L. P. Egg anti-inflammatory composition, method of isolation and use
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CZ287956B6 (en) * 1997-11-04 2001-03-14 Medipharm Cz, S. R. O. Peroral preparation intended for prevention and treatment of canine parvovirus infection
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WO2002038164A1 (en) 2000-11-08 2002-05-16 Lorus Therapeutics Inc. Combination preparation of a biological response modifier and an anticancer agent and uses thereof
US20030003117A1 (en) 2001-06-18 2003-01-02 Michael Marenick Hydrolyzed whole egg products & related methods
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US6866868B1 (en) 2003-09-15 2005-03-15 4Life Research, Lc Compositions including different types of transfer factor, methods for making the compositions, and methods of treatment using the compositions
US10471100B2 (en) 2006-09-29 2019-11-12 4Life Patents, Llc Nanofraction immune modulators, preparations and compositions including the same, and associated methods
CN100502674C (en) 2005-10-13 2009-06-24 复旦大学 Cow colostrums and mushroom extracts composition, its preparation method and application

Also Published As

Publication number Publication date
EP2068913A4 (en) 2009-12-02
JP6401744B2 (en) 2018-10-10
CN101553247B (en) 2015-08-19
RU2014102562A (en) 2015-08-20
JP2016196491A (en) 2016-11-24
RU2518341C2 (en) 2014-06-10
MY158857A (en) 2016-11-15
EP2068913B1 (en) 2017-11-01
US20080081076A1 (en) 2008-04-03
AU2007305076B2 (en) 2011-04-28
WO2008042604A2 (en) 2008-04-10
ES2658107T3 (en) 2018-03-08
SG160430A1 (en) 2010-04-29
JP2014129413A (en) 2014-07-10
US10471100B2 (en) 2019-11-12
US11197894B2 (en) 2021-12-14
TWI449530B (en) 2014-08-21
WO2008042604A3 (en) 2008-11-06
MY188915A (en) 2022-01-13
RU2009116274A (en) 2010-11-10
EP2068913A2 (en) 2009-06-17
CN101553247A (en) 2009-10-07
US20200069737A1 (en) 2020-03-05
TW200831116A (en) 2008-08-01
CO6220833A2 (en) 2010-11-19
RU2619555C2 (en) 2017-05-16
ECSP099296A (en) 2010-02-26
HK1138181A1 (en) 2010-08-20
JP5592651B2 (en) 2014-09-17
JP2010504988A (en) 2010-02-18
AU2007305076A1 (en) 2008-04-10

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