MX2007011649A - Process for the production of methylcobalamin. - Google Patents

Process for the production of methylcobalamin.

Info

Publication number
MX2007011649A
MX2007011649A MX2007011649A MX2007011649A MX2007011649A MX 2007011649 A MX2007011649 A MX 2007011649A MX 2007011649 A MX2007011649 A MX 2007011649A MX 2007011649 A MX2007011649 A MX 2007011649A MX 2007011649 A MX2007011649 A MX 2007011649A
Authority
MX
Mexico
Prior art keywords
methylcobalamin
production
hydroxocobalamin
cyanocobalamin
methylation
Prior art date
Application number
MX2007011649A
Other languages
Spanish (es)
Inventor
Ines Petschen
Xavier Camps
Juan Sallares
Original Assignee
Ferrer Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Int filed Critical Ferrer Int
Publication of MX2007011649A publication Critical patent/MX2007011649A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a new process for the production of methylcobalamin that comprises the methylation of cyanocobalamin or hydroxocobalamin with dimethyl carbonate in the presence of a reducing agent.
MX2007011649A 2005-03-23 2006-03-22 Process for the production of methylcobalamin. MX2007011649A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200500703A ES2264374B1 (en) 2005-03-23 2005-03-23 METHODCOBALAMINE MANUFACTURING PROCEDURE.
PCT/EP2006/002635 WO2006100059A1 (en) 2005-03-23 2006-03-22 Process for the production of methylcobalamin

Publications (1)

Publication Number Publication Date
MX2007011649A true MX2007011649A (en) 2007-11-14

Family

ID=36304703

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007011649A MX2007011649A (en) 2005-03-23 2006-03-22 Process for the production of methylcobalamin.

Country Status (16)

Country Link
EP (1) EP1861415A1 (en)
JP (1) JP2008534458A (en)
KR (1) KR20070106791A (en)
CN (1) CN101175764A (en)
AR (1) AR053558A1 (en)
AU (1) AU2006226577A1 (en)
BR (1) BRPI0609125A2 (en)
CA (1) CA2600987A1 (en)
ES (1) ES2264374B1 (en)
IL (1) IL185722A0 (en)
MX (1) MX2007011649A (en)
NO (1) NO20075211L (en)
RU (1) RU2007139143A (en)
TW (1) TW200700430A (en)
UY (1) UY29432A1 (en)
WO (1) WO2006100059A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012165934A1 (en) * 2011-05-30 2012-12-06 Interquim, S.A. De C.V. Methylcobalamin synthesis process
CN102391340A (en) * 2011-10-31 2012-03-28 河北玉星生物工程有限公司 Preparation method of mecobalamin
CN103113443B (en) * 2013-02-01 2015-02-11 山东省医药工业研究所 Novel chemical synthesis method for preparing mecobalamine
CN105218608A (en) * 2015-10-29 2016-01-06 无锡福祈制药有限公司 A kind of preparation method of mecobalamin
CN108948116A (en) * 2018-08-30 2018-12-07 上海应用技术大学 A kind of green synthesis process of Mecobalamin
CN114874276B (en) * 2022-04-21 2024-06-21 南京工业大学 Improved method for synthesizing mecobalamin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759614A (en) * 1969-12-01 1971-06-01 Glaxo Lab Ltd CYANIDE ION REMOVAL FROM CORRINOID SOLUTIONS
US3928320A (en) * 1971-11-10 1975-12-23 Jean Boige Process for the preparation of methylcobalamine
KR100694688B1 (en) * 1999-12-09 2007-03-13 에자이 알앤드디 매니지먼트 가부시키가이샤 Process for production of methylcobalamin
EP1394174B1 (en) * 2001-06-05 2015-11-11 Eisai R&D Management Co., Ltd. Process for producing methylcobalamin

Also Published As

Publication number Publication date
EP1861415A1 (en) 2007-12-05
CA2600987A1 (en) 2006-09-28
AR053558A1 (en) 2007-05-09
BRPI0609125A2 (en) 2010-02-23
UY29432A1 (en) 2006-06-30
IL185722A0 (en) 2008-01-06
RU2007139143A (en) 2009-04-27
ES2264374A1 (en) 2006-12-16
CN101175764A (en) 2008-05-07
JP2008534458A (en) 2008-08-28
NO20075211L (en) 2007-10-11
WO2006100059A1 (en) 2006-09-28
KR20070106791A (en) 2007-11-05
AU2006226577A1 (en) 2006-09-28
ES2264374B1 (en) 2007-11-01
TW200700430A (en) 2007-01-01

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Legal Events

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