MX2007004414A - System and method for production of antibodies in plant cell culture. - Google Patents

System and method for production of antibodies in plant cell culture.

Info

Publication number
MX2007004414A
MX2007004414A MX2007004414A MX2007004414A MX2007004414A MX 2007004414 A MX2007004414 A MX 2007004414A MX 2007004414 A MX2007004414 A MX 2007004414A MX 2007004414 A MX2007004414 A MX 2007004414A MX 2007004414 A MX2007004414 A MX 2007004414A
Authority
MX
Mexico
Prior art keywords
antibodies
production
cell culture
plant cell
vectors
Prior art date
Application number
MX2007004414A
Other languages
Spanish (es)
Inventor
Yoseph Shaaltiel
Gideon Baum
Sharon Hashmueli
Daniel Bartfeld
Tal Ratz
Einat Mizrachi
Yehava Forester
Original Assignee
Protalix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protalix Ltd filed Critical Protalix Ltd
Publication of MX2007004414A publication Critical patent/MX2007004414A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/13—Immunoglobulins specific features characterized by their source of isolation or production isolated from plants

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A system and method for production of antibodies in plant cell culture, which results in highly functional antibodies, produced with a high level of expression efficiency. The present invention also encompasses host cells, vectors and methods for mass production of full size assembled immunoglobulins.
MX2007004414A 2004-10-13 2005-10-11 System and method for production of antibodies in plant cell culture. MX2007004414A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61764604P 2004-10-13 2004-10-13
PCT/IL2005/001075 WO2006040764A2 (en) 2004-10-13 2005-10-11 System and method for production of antibodies in plant cell culture

Publications (1)

Publication Number Publication Date
MX2007004414A true MX2007004414A (en) 2007-09-25

Family

ID=35462268

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007004414A MX2007004414A (en) 2004-10-13 2005-10-11 System and method for production of antibodies in plant cell culture.

Country Status (12)

Country Link
US (1) US8119406B2 (en)
EP (1) EP1799813B1 (en)
JP (1) JP2008515454A (en)
KR (1) KR20070085291A (en)
AT (1) ATE468390T1 (en)
AU (1) AU2005293147A1 (en)
CA (1) CA2583691A1 (en)
DE (1) DE602005021379D1 (en)
IL (1) IL182517A (en)
MX (1) MX2007004414A (en)
WO (1) WO2006040764A2 (en)
ZA (1) ZA200703124B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL155588A0 (en) * 2003-04-27 2003-11-23 Metabogal Ltd Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby
US20050032211A1 (en) * 1996-09-26 2005-02-10 Metabogal Ltd. Cell/tissue culturing device, system and method
US7951557B2 (en) 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
US20100196345A1 (en) * 2003-04-27 2010-08-05 Protalix Production of high mannose proteins in plant culture
ATE468390T1 (en) 2004-10-13 2010-06-15 Protalix Ltd SYSTEM AND METHOD FOR PRODUCING ANTIBODIES IN PLANT CELL CULTURE
US8338134B2 (en) 2007-02-09 2012-12-25 Centre National De La Recherche Scientifique - Cnrs Expression of polypeptides from the nuclear genome of Ostreococcus sp
SG187447A1 (en) 2007-05-07 2013-02-28 Protalix Ltd Large scale disposable bioreactor
WO2010117786A1 (en) 2009-03-30 2010-10-14 Mount Sinai School Of Medicine Of New York University Influenza virus vaccines and uses thereof
KR102608551B1 (en) 2009-08-28 2023-12-04 이칸 스쿨 오브 메디슨 엣 마운트 시나이 Dose escalation enzyme replacement therapy for treating acid sphingomyelinase deficiency
EP3248615A1 (en) 2010-03-30 2017-11-29 Mount Sinai School of Medicine of New York University Influenza virus vaccines and uses thereof
EP2758075B1 (en) 2011-09-20 2023-05-03 Icahn School of Medicine at Mount Sinai Influenza virus vaccines and uses thereof
BR112015014482A2 (en) 2012-12-18 2017-11-21 Icahn School Med Mount Sinai influenza vaccines and their uses
WO2014159960A1 (en) 2013-03-14 2014-10-02 Icahn School Of Medicine At Mount Sinai Antibodies against influenza virus hemagglutinin and uses thereof
WO2015105551A1 (en) * 2014-01-09 2015-07-16 Kentucky Bioprocessing, Inc. Method of purifying monoclonal antibodies
GB201411802D0 (en) 2014-07-02 2014-08-13 Univ Bradford Effervescent compositions
US9340604B1 (en) 2014-10-29 2016-05-17 Aridis Pharmaceuticals, Inc. Human monoclonal antibody specific for the F protein of respiratory syncytial virus (RSV)
WO2016118937A1 (en) 2015-01-23 2016-07-28 Icahn School Of Medicine At Mount Sinai Influenza virus vaccination regimens
JP7237344B2 (en) 2016-06-15 2023-03-13 アイカーン スクール オブ メディシン アット マウント サイナイ Influenza virus hemagglutinin protein and uses thereof
WO2018100866A1 (en) 2016-11-30 2018-06-07 キリン株式会社 Method for producing useful protein by means of plant
EP3606555A4 (en) 2017-04-07 2021-08-04 Icahn School of Medicine at Mount Sinai Anti-influenza b virus neuraminidase antibodies and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6080560A (en) * 1994-07-25 2000-06-27 Monsanto Company Method for producing antibodies in plant cells
AR020090A1 (en) * 1998-06-15 2002-04-10 John Innes Ct MONOCOTILEDONE VEGETABLE CELL OR SEED OF HER, PLANT OR PART OF A PLANT, METHOD FOR MAKING A MONOCOTILEDONE VEGETABLE CELL, METHOD FOR MAKING AN APPLIANCE, USE OF AN EXPRESSION CONSTRUCTION TO PRODUCE A PLANT CELL AND SED OF CONSTRUCTION EXPRESSION
WO2000011953A1 (en) * 1998-09-01 2000-03-09 Penn State Research Foundation Method and apparatus for aseptic growth or processing of biomass
US6528063B2 (en) * 1999-01-04 2003-03-04 Rahan Meristem Recombinant vaccines against IBDV
US6962700B1 (en) * 2000-09-13 2005-11-08 Atopix Pharmaceuticals Corporation Method of manufacturing immune globulin
CN1533438A (en) * 2001-06-08 2004-09-29 �����Ŵ��Ƽ���˾ Method for producing proteins in plants
WO2003013598A2 (en) 2001-08-09 2003-02-20 Lam Dominic M K Novel vaccine compositions and methods of vaccine preparation for veterinary and human diseases
CL2003002461A1 (en) 2002-11-27 2005-01-07 Dow Chemical Company Agroscien IMMUNOGLOBULIN THAT UNDERSTANDS AT LEAST ONE AFUCOSILATED GLICAN, COMPOSITION THAT CONTAINS IT, NUCLEOTIDIC SEQUENCE AND VECTOR THAT UNDERSTANDS IT, PROCEDURE TO PRODUCE IMMUNOGLOBULIN SAID IN PLANTS.
ATE335084T1 (en) 2002-12-20 2006-08-15 Greenovation Biotech Gmbh METHOD FOR PRODUCING GLYCOSYLATED PROTEINS IN BRYOPHYTE CELLS
ATE468390T1 (en) 2004-10-13 2010-06-15 Protalix Ltd SYSTEM AND METHOD FOR PRODUCING ANTIBODIES IN PLANT CELL CULTURE

Also Published As

Publication number Publication date
US20090082548A1 (en) 2009-03-26
WO2006040764A3 (en) 2006-07-06
AU2005293147A1 (en) 2006-04-20
ZA200703124B (en) 2008-08-27
IL182517A (en) 2012-06-28
EP1799813B1 (en) 2010-05-19
CA2583691A1 (en) 2006-04-20
IL182517A0 (en) 2007-09-20
KR20070085291A (en) 2007-08-27
ATE468390T1 (en) 2010-06-15
EP1799813A2 (en) 2007-06-27
JP2008515454A (en) 2008-05-15
WO2006040764A2 (en) 2006-04-20
DE602005021379D1 (en) 2010-07-01
US8119406B2 (en) 2012-02-21

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