MX172723B - PROCESS - Google Patents

PROCESS

Info

Publication number
MX172723B
MX172723B MX1903790A MX1903790A MX172723B MX 172723 B MX172723 B MX 172723B MX 1903790 A MX1903790 A MX 1903790A MX 1903790 A MX1903790 A MX 1903790A MX 172723 B MX172723 B MX 172723B
Authority
MX
Mexico
Prior art keywords
mixture
streptokinase
group
contaminating proteins
reacting
Prior art date
Application number
MX1903790A
Other languages
Spanish (es)
Inventor
Julian Stanley Harber
Christopher Joseph Mannix
Richard Anthony Godwin Smith
Ceri John Lewis
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Priority to MX1903790A priority Critical patent/MX172723B/en
Publication of MX172723B publication Critical patent/MX172723B/en

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  • Enzymes And Modification Thereof (AREA)

Abstract

La presente invención se refiere a un procedimiento para la separación de estreptocinasa a partir de proteínas contaminantes en una mezcla que contiene estreptocinasa, el procedimiento está caracterizado porque comprende tratar la mezcla con un agente de reducción a fin de reducir los puentes de disulfuro en las proteínas contaminantes para liberar grupos tiol, además poner en contacto la mezcla con un reactivo R-X en donde R es un grupo capaz de reaccionar con un grupo tiol libre y X es un grupo R1 capaz de reaccionar con un grupo tiol libre o es una matriz que contiene tiol, y posteriormente separar las proteínas contaminantes resultantes modificadas químicamente de la mezcla para proporcionar estreptocinasa en una forma substancialmente libre de proteínas contaminantes.The present invention relates to a method for separating streptokinase from contaminating proteins in a mixture containing streptokinase, the method is characterized in that it comprises treating the mixture with a reducing agent in order to reduce disulfide bridges in the proteins. contaminants to release thiol groups, further contacting the mixture with a reagent RX where R is a group capable of reacting with a free thiol group and X is a group R1 capable of reacting with a free thiol group or is a matrix containing thiol, and subsequently separating the resulting chemically modified contaminating proteins from the mixture to provide streptokinase in a form substantially free of contaminating proteins.

MX1903790A 1990-01-08 1990-01-08 PROCESS MX172723B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MX1903790A MX172723B (en) 1990-01-08 1990-01-08 PROCESS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MX1903790A MX172723B (en) 1990-01-08 1990-01-08 PROCESS

Publications (1)

Publication Number Publication Date
MX172723B true MX172723B (en) 1994-01-10

Family

ID=19742483

Family Applications (1)

Application Number Title Priority Date Filing Date
MX1903790A MX172723B (en) 1990-01-08 1990-01-08 PROCESS

Country Status (1)

Country Link
MX (1) MX172723B (en)

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