MX172696B - NEW ANTIGENS AND METHOD FOR ITS PRODUCTION - Google Patents
NEW ANTIGENS AND METHOD FOR ITS PRODUCTIONInfo
- Publication number
- MX172696B MX172696B MX2196890A MX2196890A MX172696B MX 172696 B MX172696 B MX 172696B MX 2196890 A MX2196890 A MX 2196890A MX 2196890 A MX2196890 A MX 2196890A MX 172696 B MX172696 B MX 172696B
- Authority
- MX
- Mexico
- Prior art keywords
- protein
- sequence
- modified
- necessary
- production
- Prior art date
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención se refiere a un metodo para producir una proteína de superficie grande, modificada del virus de la hepatitis B, que comprende una secuencia de aminoácidos que codifican para la proteína L, caracterizada por una modificación en cuando menos una de las siguientes secuencias: una secuencia sensible a la digestión con proteasa, una secuencia necesaria para la miristilación, una secuencia necesaria para la glicosilación unida a O, y una secuencia necesaria para el enlace de la albúmina de suero humano, el metodo está caracterizado porque comprende cultivar una celula huesped que comprende una secuencia de codificación de ADN para la expresión de la proteína L modificada en medios de cultivo apropiados y aislamiento de la proteína del lisado celular o el extracto del cultivo.The present invention relates to a method of producing a large surface protein, modified from the hepatitis B virus, comprising an amino acid sequence encoding the L protein, characterized by a modification in at least one of the following sequences: a sequence sensitive to protease digestion, a sequence necessary for myristylation, a sequence necessary for O-linked glycosylation, and a sequence necessary for binding of human serum albumin, the method is characterized in that it involves culturing a host cell comprising a DNA coding sequence for expression of the modified L protein in appropriate culture media and isolation of the protein from the cell lysate or the culture extract.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2196890A MX172696B (en) | 1990-08-14 | 1990-08-14 | NEW ANTIGENS AND METHOD FOR ITS PRODUCTION |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2196890A MX172696B (en) | 1990-08-14 | 1990-08-14 | NEW ANTIGENS AND METHOD FOR ITS PRODUCTION |
Publications (1)
Publication Number | Publication Date |
---|---|
MX172696B true MX172696B (en) | 1994-01-07 |
Family
ID=19742585
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2196890A MX172696B (en) | 1990-08-14 | 1990-08-14 | NEW ANTIGENS AND METHOD FOR ITS PRODUCTION |
Country Status (1)
Country | Link |
---|---|
MX (1) | MX172696B (en) |
-
1990
- 1990-08-14 MX MX2196890A patent/MX172696B/en unknown
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