MTP4274B - Boron-iodine 124 compounds and their use in bnct with dosimetry - Google Patents
Boron-iodine 124 compounds and their use in bnct with dosimetryInfo
- Publication number
- MTP4274B MTP4274B MTP0004274A MTP4274A MTP4274B MT P4274 B MTP4274 B MT P4274B MT P0004274 A MTP0004274 A MT P0004274A MT P4274 A MTP4274 A MT P4274A MT P4274 B MTP4274 B MT P4274B
- Authority
- MT
- Malta
- Prior art keywords
- boron
- compounds
- bnct
- tumor
- cell
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- NAFOIZPSUNESOU-UHFFFAOYSA-N [B].[I] Chemical compound [B].[I] NAFOIZPSUNESOU-UHFFFAOYSA-N 0.000 title 1
- 238000004980 dosimetry Methods 0.000 title 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 abstract 5
- 229910052796 boron Inorganic materials 0.000 abstract 5
- 210000004027 cell Anatomy 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 210000004881 tumor cell Anatomy 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 201000010915 Glioblastoma multiforme Diseases 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 208000005017 glioblastoma Diseases 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Method for the synthesis of compounds to be used in BNCT and in monitoring the uptake to tumor tissue. The compounds comprise a stable boron containing group and a not stable radioisotopes I 24-Iodine. The key to successful therapy with BNCT is to obtain a high ratio of boron in tumor cells compared to boron in normal cells and in blood, and to have the methods to calculate "in vivo" exactly the quantity of boron up-take in tumor cells. With the compounds of the invention, higher ratios of boron concentration in a target tumor compared to normal tissue may be achieved than with prior art compounds, such as 20:1. In another embodiment there are provided methods of treatments with glioblastoma multiforme cell and with malignant melanomas ( for which it is reported, there currently is no effective therapy), killing tumor cell without adversely affecting the healthy cell.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MTP0004274A MTP4274B (en) | 2009-12-31 | 2009-12-31 | Boron-iodine 124 compounds and their use in bnct with dosimetry |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MTP0004274A MTP4274B (en) | 2009-12-31 | 2009-12-31 | Boron-iodine 124 compounds and their use in bnct with dosimetry |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MTP4274B true MTP4274B (en) | 2011-07-04 |
Family
ID=60629306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MTP0004274A MTP4274B (en) | 2009-12-31 | 2009-12-31 | Boron-iodine 124 compounds and their use in bnct with dosimetry |
Country Status (1)
| Country | Link |
|---|---|
| MT (1) | MTP4274B (en) |
-
2009
- 2009-12-31 MT MTP0004274A patent/MTP4274B/en unknown
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