ME03574B - USEFUL HETERARYL COMPOUNDS AS SUMO ACTIVATIVE ENZYME INHIBITORS - Google Patents

USEFUL HETERARYL COMPOUNDS AS SUMO ACTIVATIVE ENZYME INHIBITORS

Info

Publication number
ME03574B
ME03574B MEP-2019-312A MEP2019312A ME03574B ME 03574 B ME03574 B ME 03574B ME P2019312 A MEP2019312 A ME P2019312A ME 03574 B ME03574 B ME 03574B
Authority
ME
Montenegro
Prior art keywords
activative
heteraryl
sumo
compounds
useful
Prior art date
Application number
MEP-2019-312A
Other languages
German (de)
French (fr)
Unknown language (me)
Inventor
Matthew O Duffey
Dylan England
Scott Freeze
Zhigen Hu
Steven P Langston
Charles Mcintyre
Hirotake Mizutani
Koji Ono
He Xu
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55019950&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME03574(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of ME03574B publication Critical patent/ME03574B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/535—Organo-phosphoranes
    • C07F9/5352—Phosphoranes containing the structure P=C-
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5442—Aromatic phosphonium compounds (P-C aromatic linkage)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
MEP-2019-312A 2014-07-01 2015-06-30 USEFUL HETERARYL COMPOUNDS AS SUMO ACTIVATIVE ENZYME INHIBITORS ME03574B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462019756P 2014-07-01 2014-07-01
US201562185678P 2015-06-28 2015-06-28
EP15815330.4A EP3164130B1 (en) 2014-07-01 2015-06-30 Heteroaryl compounds useful as inhibitors of sumo activating enzyme
PCT/US2015/038712 WO2016004136A1 (en) 2014-07-01 2015-06-30 Heteroaryl compounds useful as inhibitors of sumo activating enzyme

Publications (1)

Publication Number Publication Date
ME03574B true ME03574B (en) 2020-07-20

Family

ID=55019950

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2019-312A ME03574B (en) 2014-07-01 2015-06-30 USEFUL HETERARYL COMPOUNDS AS SUMO ACTIVATIVE ENZYME INHIBITORS

Country Status (39)

Country Link
US (6) US9683003B2 (en)
EP (3) EP3517112B1 (en)
JP (4) JP6603712B2 (en)
KR (1) KR102491125B1 (en)
CN (1) CN106999479B (en)
AU (1) AU2015284135B2 (en)
BR (1) BR112016030787B1 (en)
CA (1) CA2953132C (en)
CL (1) CL2016003398A1 (en)
CR (1) CR20170021A (en)
CY (1) CY1122808T1 (en)
DK (1) DK3164130T3 (en)
DO (1) DOP2016000339A (en)
EA (1) EA034119B1 (en)
EC (1) ECSP17006751A (en)
ES (1) ES2754359T3 (en)
GE (1) GEP20197047B (en)
HR (1) HRP20191979T1 (en)
HU (1) HUE045748T2 (en)
IL (1) IL249820B (en)
LT (1) LT3164130T (en)
ME (1) ME03574B (en)
MX (1) MX376054B (en)
MY (1) MY183649A (en)
NZ (1) NZ728162A (en)
PE (1) PE20170520A1 (en)
PH (1) PH12016502595B1 (en)
PL (1) PL3164130T3 (en)
PT (1) PT3164130T (en)
RS (1) RS59474B1 (en)
SG (1) SG11201610476VA (en)
SI (1) SI3164130T1 (en)
SM (1) SMT201900600T1 (en)
TN (1) TN2016000581A1 (en)
TW (1) TWI680970B (en)
UA (1) UA122963C2 (en)
UY (1) UY36198A (en)
WO (1) WO2016004136A1 (en)
ZA (1) ZA201700386B (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA116534C2 (en) 2012-02-17 2018-04-10 Мілленніум Фармасьютікалз, Інк. Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
WO2014022744A1 (en) 2012-08-03 2014-02-06 Millennium Pharmaceuticals, Inc. INDOLE-SUBSTITUTED PYRROLOPYRIMIDINYL INHIBITORS OF Uba6
NZ728162A (en) 2014-07-01 2023-06-30 Takeda Pharmaceuticals Co Heteroaryl compounds useful as inhibitors of sumo activating enzyme
US10465447B2 (en) 2015-03-12 2019-11-05 Baker Hughes, A Ge Company, Llc Cutting elements configured to mitigate diamond table failure, earth-boring tools including such cutting elements, and related methods
TWI730980B (en) 2015-08-26 2021-06-21 比利時商健生藥品公司 Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as prmt5 inhibitors
AU2017338269B2 (en) 2016-10-03 2021-03-25 Janssen Pharmaceutica Nv Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as PRMT5 inhibitors
WO2018154104A1 (en) 2017-02-27 2018-08-30 Janssen Pharmaceutica Nv Use of biomarkers in identifying cancer patients that will be responsive to treatment with a prmt5 inhibitor
WO2018166855A1 (en) 2017-03-16 2018-09-20 Basf Se Heterobicyclic substituted dihydroisoxazoles
US10400517B2 (en) 2017-05-02 2019-09-03 Baker Hughes, A Ge Company, Llc Cutting elements configured to reduce impact damage and related tools and methods
EP3684363A4 (en) 2017-09-21 2021-05-12 Millennium Pharmaceuticals, Inc. COCONUT CRYSTAL FORMS OF ((1S, 2S, 4R) -4- {4 - [(1S) -2,3-DIHYDRO-1H-INDEN-1-YLAMINO] -7H-PYRROLO [2,3-D] PYRIMIDINE-7- YL} -2-HYDROXYCYCLOPENTYL) -METHYL SULFAMATE, FORMULATIONS AND USES THEREOF
BR112020010815A2 (en) 2017-12-08 2020-11-10 Janssen Pharmaceutica Nv spirobicyclic analogs
US20210015915A1 (en) 2018-03-23 2021-01-21 Takeda Pharmaceutical Company Limited Sting modulator compounds with sulfamate linkages, and methods of making and using
EP3781156A4 (en) 2018-04-16 2022-05-18 C4 Therapeutics, Inc. SPIROCYCLIC COMPOUNDS
MX2021000349A (en) * 2018-07-09 2021-05-14 Takeda Pharmaceuticals Co Administration of sumo-activating enzyme inhibitor and anti-cd20 antibodies.
US10570668B2 (en) 2018-07-27 2020-02-25 Baker Hughes, A Ge Company, Llc Cutting elements configured to reduce impact damage and mitigate polycrystalline, superabrasive material failure earth-boring tools including such cutting elements, and related methods
CN109354569A (en) * 2018-11-27 2019-02-19 常州大学 A kind of preparation method of 1,3-dibromo-4-fluorobenzene
EP3930720A4 (en) * 2019-02-26 2022-12-28 Millennium Pharmaceuticals, Inc. Compounds useful as adjuvants
CA3128521A1 (en) * 2019-02-27 2020-09-03 Millennium Pharmaceuticals, Inc. Administration of sumo-activating enzyme inhibitor and checkpoint inhibitors
TW202112375A (en) 2019-06-06 2021-04-01 比利時商健生藥品公司 Methods of treating cancer using prmt5 inhibitors
EP3782702A1 (en) * 2019-08-21 2021-02-24 AC BioScience SA Compounds and use thereof for the treatment of infectious diseases and cancer
CN112402608B (en) * 2020-11-30 2021-09-07 深圳先进技术研究院 Application of 5-alkoxyindole-3-vinylquinoline salts as targeted transferable photosensitizers
WO2021203001A1 (en) * 2020-04-03 2021-10-07 Millennium Pharmaceuticals, Inc. Method of treating patients infected with a viral infection with an inhibitor of small ubiquitin like modifier activating enzyme
AU2021271808A1 (en) * 2020-05-15 2023-01-05 Takeda Pharmaceutical Company Limited Administration of SUMO-activating enzyme inhibitor and anti-CD38 antibodies
CN116917594A (en) 2021-02-05 2023-10-20 贝克休斯油田作业有限责任公司 Cutting element for an earth-boring tool and method of manufacturing an earth-boring tool
CN113173852B (en) * 2021-04-26 2022-07-12 深圳市华先医药科技有限公司 Preparation method of difluoro malonate type compound
WO2023073645A1 (en) 2021-10-29 2023-05-04 Takeda Pharmaceutical Company Limited Therapy comprising anti-cd19 antibody and sumo-activating enzyme inhibitor
US11920409B2 (en) 2022-07-05 2024-03-05 Baker Hughes Oilfield Operations Llc Cutting elements, earth-boring tools including the cutting elements, and methods of forming the earth-boring tools
EP4596557A1 (en) 2022-09-30 2025-08-06 Wigen Biomedicine Technology (Shanghai) Co., Ltd. Compound as inhibitor for sumo activating enzyme
CN120112536A (en) * 2022-11-11 2025-06-06 微境生物医药科技(上海)有限公司 Compounds as inhibitors of SUMO activating enzymes
WO2024110863A1 (en) 2022-11-22 2024-05-30 Takeda Pharmaceutical Company Limited Process and intermediates for preparing ((1r,2s,4r)-4-((5-(4-((r)-7-chloro-1,2,3,4-tetrahydroisoquinolin-1-yl)-5-methylthiophene-2-carbonyl)pyrimidin-4-yl)amino)-2-hydroxycyclopentyl)methyl sulfamate
CN117209449B (en) * 2023-09-14 2025-11-28 上海毕得医药科技股份有限公司 Synthesis method of 2- (trifluoromethyl) thiazole compound
NL2035852B1 (en) 2023-09-21 2025-03-28 Academisch Ziekenhuis Leiden Enhancement of t cell mediated therapies
CN119371416B (en) * 2024-12-23 2025-05-30 上海达歌生物医药科技有限公司 Synthesis method for constructing 4-substituted isocoumarin and analogues thereof through oxetane ring opening

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194446A (en) 1989-06-12 1993-03-16 A. H. Robins Company, Incorporated Compounds having one or more aminosulfaonyloxy radicals useful as pharmaceuticals
WO1997005132A1 (en) 1995-07-28 1997-02-13 Cubist Pharmaceuticals, Inc. Aminoacyl adenylate mimics as novel antimicrobial and antiparasitic agents
JP2005524662A (en) 2002-02-28 2005-08-18 ビオタ インコーポレーティッド Nucleoside 5'-monophosphate mimetics and their prodrugs
JP2005525398A (en) * 2002-04-10 2005-08-25 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド Novel heteroarylalkylamide derivatives useful as bradykinin receptor modulators
US7527966B2 (en) 2002-06-26 2009-05-05 Transgenrx, Inc. Gene regulation in transgenic animals using a transposon-based vector
US7291603B2 (en) 2002-07-24 2007-11-06 Ptc Therapeutics, Inc. Nucleoside compounds and their use for treating cancer and diseases associated with somatic mutations
AU2003261237A1 (en) 2002-07-24 2004-02-09 Ptc Therapeutics, Inc. Use of nucleoside compounds for nonsense suppression and the treatment of genetic diseases
US7196092B2 (en) 2002-09-04 2007-03-27 Schering Corporation N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors
NZ539162A (en) 2002-09-04 2006-07-28 Schering Corp Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7563798B2 (en) 2002-09-04 2009-07-21 Schering Corporation Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
DE60313872T2 (en) 2002-09-04 2008-01-17 Schering Corp. PYRAZOLOE1,5-ATPYRIMIDINES AS INHIBITORS CYCLINE-DEPENDENT KINASES
WO2004043955A1 (en) 2002-11-13 2004-05-27 Rigel Pharmaceuticals, Inc. Rhodanine derivatives and pharmaceutical compositions containing them
US7157455B2 (en) * 2003-02-10 2007-01-02 Hoffmann-La Roche Inc. 4-Aminopyrimidine-5-one derivatives
EP1608652A1 (en) 2003-03-31 2005-12-28 Vernalis (Cambridge) Limited Pyrazolopyrimidine compounds and their use in medicine
JP2005008581A (en) 2003-06-20 2005-01-13 Kissei Pharmaceut Co Ltd NEW PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME AND APPLICATION THEREOF
WO2005037845A1 (en) 2003-10-17 2005-04-28 Rigel Pharmaceuticals, Inc. Benzothiazole and thiazole[5,5-b] pyridine compositions and their use as ubiquitin ligase inhibitors
WO2005051949A1 (en) 2003-11-26 2005-06-09 Dainippon Sumitomo Pharma Co., Ltd. Novel condensed imidazole derivative
WO2006002284A1 (en) 2004-06-22 2006-01-05 Rigel Pharmaceuticals, Inc. Ubiquitin ligase inhibitors
SI1848718T1 (en) 2005-02-04 2012-12-31 Millennium Pharmaceuticals, Inc. Inhibitors of e1 activating enzymes
WO2007044426A2 (en) 2005-10-06 2007-04-19 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
JP5231251B2 (en) 2006-02-02 2013-07-10 ミレニアム ファーマシューティカルズ， インコーポレイテッド Inhibitor of E1 activating enzyme
CA2659894C (en) * 2006-08-08 2018-03-27 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of e1 activating enzymes
US8008307B2 (en) 2006-08-08 2011-08-30 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of E1 activating enzymes
CA2691987C (en) 2007-06-12 2016-08-16 Achaogen, Inc. Antibacterial agents
MX2010001126A (en) 2007-08-02 2010-03-01 Millennium Pharm Inc Process for the synthesis of e1 activating enzyme inhibitors.
WO2009082691A1 (en) 2007-12-21 2009-07-02 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity
US9334242B2 (en) 2008-06-16 2016-05-10 Gtx, Inc. Compounds for treatment of cancer
EP2326626B1 (en) 2008-08-20 2013-10-16 Merck Sharp & Dohme Corp. Ethenyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
WO2010022125A1 (en) 2008-08-20 2010-02-25 Schering Corporation Ethynyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
AR072938A1 (en) 2008-08-20 2010-09-29 Southern Res Inst DERIVATIVES OF PIRIDINE AND PYRIMIDINE AZOSUSTITUIDOS AND ITS USE IN THE TREATMENT OF VIRAL INFECTIONS
CA2734486A1 (en) 2008-08-20 2010-02-25 Southern Research Institute Substituted pyridine and pyrimidine derivatives and their use in treating viral infections
US8962580B2 (en) 2008-09-23 2015-02-24 Alnylam Pharmaceuticals, Inc. Chemical modifications of monomers and oligonucleotides with cycloaddition
WO2010086040A1 (en) 2009-01-29 2010-08-05 Biomarin Iga, Ltd. Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
WO2010088518A2 (en) 2009-01-31 2010-08-05 Kalypsys, Inc. Heterocyclic modulators of gpr119 for treatment of disease
BRPI1012142A2 (en) 2009-05-14 2016-03-29 Millennium Pharm Inc ((1s, 2s, 4r) -4- {4 - [(1s) -2,3-dihydro-1h-inden-1-ylamino] -7h-pyrrolo [2,3-d] pyrimidin-7 hydrochloride salt -yl} -2-hydroxycyclopentyl) methyl sulfamate
CA2771190C (en) 2009-08-17 2020-01-21 Memorial Sloan-Kettering Cancer Center Heat shock protein binding compounds, compositions, and methods for making and using same
US9198972B2 (en) 2010-01-28 2015-12-01 Alnylam Pharmaceuticals, Inc. Monomers and oligonucleotides comprising cycloaddition adduct(s)
WO2011103441A1 (en) 2010-02-18 2011-08-25 Schering Corporation Substituted pyridine and pyrimidine derivatives and their use in treating viral infections
AU2011283684B2 (en) 2010-07-29 2015-08-27 Rigel Pharmaceuticals, Inc. AMPK-activating heterocyclic compounds and methods for using the same
US20120077814A1 (en) 2010-09-10 2012-03-29 Zhong Wang Sulfonamide, sulfamate, and sulfamothioate derivatives
PH12014500419A1 (en) * 2011-08-24 2020-06-22 Millennium Pharm Inc Inhibitors of nedd8-activating enzyme
WO2013066729A1 (en) 2011-10-31 2013-05-10 Merck Sharp & Dohme Corp. Aminopyrimidinones as interleukin receptor-associated kinase inhibitors
UA116534C2 (en) * 2012-02-17 2018-04-10 Мілленніум Фармасьютікалз, Інк. Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
WO2013151975A1 (en) 2012-04-02 2013-10-10 Northeastern University Compositions and methods for the inhibition of methyltransferases
CA2916468C (en) 2013-07-02 2019-07-23 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of sumo activating enzyme
US20150087673A1 (en) 2013-09-26 2015-03-26 Rigel Pharmaceuticals, Inc. Methods for using and biomarkers for ampk-activating compounds
HUE044683T2 (en) 2013-10-21 2019-11-28 Merck Patent Gmbh Heteroaryl compounds as btk inhibitors and uses thereof
WO2015110999A1 (en) 2014-01-24 2015-07-30 Piramal Enterprises Limited Ezh2 inhibitors and uses thereof
NZ728162A (en) 2014-07-01 2023-06-30 Takeda Pharmaceuticals Co Heteroaryl compounds useful as inhibitors of sumo activating enzyme

Also Published As

Publication number Publication date
EP3901159A1 (en) 2021-10-27
EP3164130A1 (en) 2017-05-10
US20200085821A1 (en) 2020-03-19
US20160009744A1 (en) 2016-01-14
BR112016030787A2 (en) 2017-08-22
KR20170032334A (en) 2017-03-22
US20180311239A1 (en) 2018-11-01
CN106999479A (en) 2017-08-01
MX376054B (en) 2025-03-07
US10335410B2 (en) 2019-07-02
BR112016030787B1 (en) 2022-12-20
JP6603712B2 (en) 2019-11-06
TWI680970B (en) 2020-01-01
US9683003B2 (en) 2017-06-20
RS59474B1 (en) 2019-12-31
EP3164130A4 (en) 2018-02-14
SG11201610476VA (en) 2017-01-27
MY183649A (en) 2021-03-05
ECSP17006751A (en) 2017-02-24
IL249820B (en) 2019-09-26
CN106999479B (en) 2021-07-16
UY36198A (en) 2016-01-29
US20170216290A1 (en) 2017-08-03
LT3164130T (en) 2019-11-25
JP2017524734A (en) 2017-08-31
AU2015284135B2 (en) 2019-11-28
US9962386B2 (en) 2018-05-08
PT3164130T (en) 2019-11-18
US20230293522A1 (en) 2023-09-21
DOP2016000339A (en) 2017-03-15
WO2016004136A1 (en) 2016-01-07
TW201613903A (en) 2016-04-16
CA2953132A1 (en) 2016-01-07
EP3517112B1 (en) 2021-04-07
BR112016030787A8 (en) 2021-07-20
TN2016000581A1 (en) 2018-04-04
SMT201900600T1 (en) 2020-01-14
UA122963C2 (en) 2021-01-27
CY1122808T1 (en) 2021-05-05
ES2754359T3 (en) 2020-04-17
EA034119B1 (en) 2019-12-30
JP2021178869A (en) 2021-11-18
MX2016016993A (en) 2017-02-27
US10780090B2 (en) 2020-09-22
NZ728162A (en) 2023-06-30
PH12016502595A1 (en) 2017-04-24
HUE045748T2 (en) 2020-01-28
CR20170021A (en) 2017-04-04
PL3164130T3 (en) 2020-02-28
US20220331316A1 (en) 2022-10-20
EA201790108A1 (en) 2017-07-31
SI3164130T1 (en) 2019-12-31
DK3164130T3 (en) 2019-10-28
EP3164130B1 (en) 2019-08-07
EP3517112A1 (en) 2019-07-31
JP2024012558A (en) 2024-01-30
ZA201700386B (en) 2018-11-28
HRP20191979T1 (en) 2020-02-07
US20170002032A9 (en) 2017-01-05
PE20170520A1 (en) 2017-05-24
JP2020023538A (en) 2020-02-13
KR102491125B1 (en) 2023-01-20
CL2016003398A1 (en) 2017-12-29
IL249820A0 (en) 2017-02-28
PH12016502595B1 (en) 2021-09-10
AU2015284135A1 (en) 2017-02-09
CA2953132C (en) 2023-04-11
GEP20197047B (en) 2019-12-10

Similar Documents

Publication Publication Date Title
ME03574B (en) USEFUL HETERARYL COMPOUNDS AS SUMO ACTIVATIVE ENZYME INHIBITORS
MA40587A (en) AMINOPYRIMIDINYL COMPOUNDS AS JAK INHIBITORS
MA51878A (en) AMINOTHIAZOLE COMPOUNDS AS C-KIT INHIBITORS
MA48994A (en) ISOQUINOLEINS USED AS HPK1 INHIBITORS
MA41140A (en) 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS PARG INHIBITORS
MA42990A (en) COMPOUNDS USEFUL AS IMMUNOMODULATORS
MA53150A (en) BENZIMIDAZOLE COMPOUNDS AS C-KIT INHIBITORS
MA55194A (en) HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
MA52063A (en) N - ((HET) ARYLMETHYL) HETEROARYL-CARBOXAMIDES COMPOUNDS AS PLASMATIC KALLICREIN INHIBITORS
EP3386981A4 (en) HETEROCYCLES USEFUL AS ANTICANCER AGENTS
MA46091A (en) BIARYL COMPOUNDS USEFUL AS IMMUNOMODULATORS
ME03776B (en) PYRIDIN-2- (1H) -ONE-QUINOLINONE DERIVATIVES AS ISOCITRATE DEHYDROGENASE INHIBITORS
MA43169A (en) HETEROCYCLIC COMPOUNDS USED AS PI3K-GAMMA INHIBITORS
MA45244A (en) SUBSTITUTED PYRIDINES USED AS DNMT1 INHIBITORS
MA54567A (en) PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS
MA41551A (en) BICYCLIC HETEROCYCLES USED AS FGFR4 INHIBITORS
MA40943A (en) SUBSTITUTED PYRROLOPYRIDINES USED AS BROMODOMA INHIBITORS
MA40940A (en) SUBSTITUTED PYRROLOPYRIDINES USED AS BROMODOMA INHIBITORS
MA53399A (en) PYRAZOLES SUBSTITUTED AS HUMAN PLASMATIC KALLICREIN INHIBITORS
MA40774A (en) DIARYLEUREA DERIVATIVES AS KINASE P38 INHIBITORS
MA45646A (en) BENZIMIDAZOLE DERIVATIVES AS MMR-GAMMA MODULATORS
BR112016019310A2 (en) production of polyolefin products.
EP3186425A4 (en) Spunbonded web comprising polylactic acid fibers
CU20160125A7 (en) DIACILGLICEROL ACILTRANSFERASA 2 INHIBITORS
EP3397629A4 (en) METALLO ENZYME INHIBITOR COMPOUNDS