ME03392B - PROLEK DERIVATIVES (E) -N-METHYL-N- (3-METHYLBENZOFURAN-2-YL) METHYL) -3- (7-OXO-5,6,7,8-TETRANIDRO-1,8-NAFTYRIDIN-3 -IL) ACRYLAMIDE - Google Patents

PROLEK DERIVATIVES (E) -N-METHYL-N- (3-METHYLBENZOFURAN-2-YL) METHYL) -3- (7-OXO-5,6,7,8-TETRANIDRO-1,8-NAFTYRIDIN-3 -IL) ACRYLAMIDE

Info

Publication number
ME03392B
ME03392B MEP-2019-159A MEP2019159A ME03392B ME 03392 B ME03392 B ME 03392B ME P2019159 A MEP2019159 A ME P2019159A ME 03392 B ME03392 B ME 03392B
Authority
ME
Montenegro
Prior art keywords
methyl
tetranidro
prolek
naftyridin
methylbenzofuran
Prior art date
Application number
MEP-2019-159A
Other languages
German (de)
French (fr)
Unknown language (me)
Inventor
John J Partridge
John Colucci
Yves Gareau
Michel Therien
Robert Zamboni
Barry Hafkin
Anthony Marfat
Helmi Zaghdane
Original Assignee
Debiopharm Int Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debiopharm Int Sa filed Critical Debiopharm Int Sa
Publication of ME03392B publication Critical patent/ME03392B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/60—Quinoline or hydrogenated quinoline ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
MEP-2019-159A 2012-06-19 2013-06-19 PROLEK DERIVATIVES (E) -N-METHYL-N- (3-METHYLBENZOFURAN-2-YL) METHYL) -3- (7-OXO-5,6,7,8-TETRANIDRO-1,8-NAFTYRIDIN-3 -IL) ACRYLAMIDE ME03392B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261661559P 2012-06-19 2012-06-19
EP13806968.7A EP2861608B8 (en) 2012-06-19 2013-06-19 Prodrug derivatives of (e)-n-methyl-n-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
PCT/IB2013/001780 WO2013190384A1 (en) 2012-06-19 2013-06-19 Prodrug derivatives of (e)-n-methyl-n-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide

Publications (1)

Publication Number Publication Date
ME03392B true ME03392B (en) 2020-01-20

Family

ID=49768192

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2019-159A ME03392B (en) 2012-06-19 2013-06-19 PROLEK DERIVATIVES (E) -N-METHYL-N- (3-METHYLBENZOFURAN-2-YL) METHYL) -3- (7-OXO-5,6,7,8-TETRANIDRO-1,8-NAFTYRIDIN-3 -IL) ACRYLAMIDE

Country Status (34)

Country Link
US (2) US8901105B2 (en)
EP (1) EP2861608B8 (en)
JP (2) JP6085026B2 (en)
KR (1) KR101720885B1 (en)
CN (1) CN104684922B (en)
AU (1) AU2013279021C1 (en)
BR (2) BR112014031635B1 (en)
CA (1) CA2875916C (en)
CL (1) CL2014003472A1 (en)
CY (1) CY1122006T1 (en)
DK (1) DK2861608T3 (en)
EA (1) EA028136B1 (en)
ES (1) ES2731474T3 (en)
HR (1) HRP20190980T1 (en)
HU (1) HUE043836T2 (en)
IL (1) IL236066A (en)
IN (1) IN2014KN02915A (en)
LT (1) LT2861608T (en)
MA (1) MA37625B1 (en)
ME (1) ME03392B (en)
MX (1) MX356695B (en)
MY (1) MY170437A (en)
NZ (1) NZ702695A (en)
PH (1) PH12014502823B1 (en)
PL (1) PL2861608T3 (en)
PT (1) PT2861608T (en)
RS (1) RS58898B1 (en)
SG (1) SG11201408100YA (en)
SI (1) SI2861608T1 (en)
SM (1) SMT201900411T1 (en)
TN (1) TN2014000506A1 (en)
TR (1) TR201909016T4 (en)
UA (1) UA113215C2 (en)
WO (1) WO2013190384A1 (en)

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EP2687533B1 (en) 2006-07-20 2017-07-19 Debiopharm International SA Acrylamide derivatives as FAB I inhibitors
HRP20190980T1 (en) 2012-06-19 2019-08-23 Debiopharm International Sa (E) -N-METHYL-N ((3-METHYLBENZOFURAN-2 IL) METHYL) -3- (7-OXO-5,6,7,8-TETRAHYDRO-1,8-NAFTYRIDIN-3-IL) DERIVATIVES acrylamide
EP3419628B1 (en) * 2016-02-26 2020-10-14 Debiopharm International SA Medicament for treatment of diabetic foot infections
WO2018048882A1 (en) 2016-09-06 2018-03-15 The Research Foundation For The State University Of New York Positron imaging tomography imaging agent composition and method for bacterial infection
KR102665710B1 (en) 2017-08-24 2024-05-14 노보 노르디스크 에이/에스 GLP-1 composition and its uses
WO2019177975A1 (en) * 2018-03-12 2019-09-19 The Board Of Trustees Of The University Of Illinois Antibiotics effective for gram-negative pathogens
BR112021009106A2 (en) * 2018-11-12 2021-08-10 Debiopharm International S.A. antibiotic compounds, manufacturing methods, pharmaceutical compositions containing them and their uses
CA3123843A1 (en) 2018-12-21 2020-06-25 Acurx Pharmaceuticals, Llc Dna polymerase iiic inhibitors and use thereof
HUE062061T2 (en) * 2019-02-14 2023-09-28 Debiopharm Int Sa Afabicin formulation, method for making the same
PH12021553086A1 (en) 2019-06-14 2023-08-14 Debiopharm Int Sa Medicament and use thereof for treating bacterial infections involving biofilm
PH12022551444A1 (en) 2019-12-19 2023-11-20 Debiopharm Int Sa Novel compounds and their use
JP7761567B2 (en) 2020-02-18 2025-10-28 ノヴォ ノルディスク アー／エス Pharmaceutical preparations
CN117881679A (en) 2021-06-23 2024-04-12 德彪药业国际股份公司 New compounds and their applications
WO2025078209A1 (en) 2023-10-09 2025-04-17 Debiopharm International S.A. Antibiotic compounds for treating bacterial infections

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