MD69C2 - The method of obtaining of N (2-(4-fluorenephenyl 1-methyl)ethyl-N-methyl-N-propinelamine's - Google Patents

The method of obtaining of N (2-(4-fluorenephenyl 1-methyl)ethyl-N-methyl-N-propinelamine's

Info

Publication number
MD69C2
MD69C2 MD94-0139A MD940139A MD69C2 MD 69 C2 MD69 C2 MD 69C2 MD 940139 A MD940139 A MD 940139A MD 69 C2 MD69 C2 MD 69C2
Authority
MD
Moldova
Prior art keywords
methyl
obtaining
propinelamine
ethyl
fluorenephenyl
Prior art date
Application number
MD94-0139A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD69B1 (en
Inventor
Zoltan Ecsery
Jozsef Knoll
Eva Somfai
Torok Zoltan
Eva Szinnyei
Karoly Moszolits
Original Assignee
Chinoin Gyogyszer -Es Vegyeszeti Termekek Gyara Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU842124A external-priority patent/HU207282B/en
Application filed by Chinoin Gyogyszer -Es Vegyeszeti Termekek Gyara Rt. filed Critical Chinoin Gyogyszer -Es Vegyeszeti Termekek Gyara Rt.
Publication of MD69B1 publication Critical patent/MD69B1/en
Publication of MD69C2 publication Critical patent/MD69C2/en

Links

Abstract

The method of obtaining of N[2-(4-fluorene phenyl 1-methyl]ethyl-Nmethyl-N-propinelamine's. The invention relates to amines, namely to the proceeding of obtaining N[2-(4-fluorenephenyl 1-methyl]ethyl-N-methyl-N-propinelamine's or of the admissible salts in pharmacology under the form of racemase or of the optic activ isomer which possess a antidepressing activity that may be used in medicine. The aim of the invention consist of obtaining the new compounds that are more active from this class. The synthesis is performed through reaction p-fluorenephenylacetone with amine, with the formula HNR, R2, where R1, 1H or propynil, R21H or methyl. Ketynine or oximine that are obtained are reduced in the case if R11H, it is propinelat and if R21H, it is methyliat. The final product are obtained under the form of a free base or of a pharmacologic salt admissed as a recemase or a activ optic isomer. The researches show that the new compounds are selected inhibitive very active of monoaminoxidore of B type and absorption inhibitive of tiraamines and biogen amines.
MD94-0139A 1984-05-31 1994-04-21 The method of obtaining of N (2-(4-fluorenephenyl 1-methyl)ethyl-N-methyl-N-propinelamine's MD69C2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU842124A HU207282B (en) 1984-05-31 1984-05-31 Process for producing phenyl-alkyl-amine derivatives and pharmaceutical compositions containing them
PCT/HU1985/000035 WO1985005617A1 (en) 1984-05-31 1985-05-31 Phenylisopropylamine derivative and its preparation
SU864015073A SU1487810A3 (en) 1984-05-31 1986-01-30 Method of producing n-/2-(4-fluorophenyl))-1-methyl/-ethyl-n-methyl-n-propylniamine

Publications (2)

Publication Number Publication Date
MD69B1 MD69B1 (en) 1994-10-31
MD69C2 true MD69C2 (en) 1995-01-31

Family

ID=26317470

Family Applications (1)

Application Number Title Priority Date Filing Date
MD94-0139A MD69C2 (en) 1984-05-31 1994-04-21 The method of obtaining of N (2-(4-fluorenephenyl 1-methyl)ethyl-N-methyl-N-propinelamine's

Country Status (3)

Country Link
LT (1) LT2176B (en)
LV (1) LV5218A3 (en)
MD (1) MD69C2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3485874A (en) * 1966-05-04 1969-12-23 Chinoin Gyogyszer Es Vegyeszet Ortho and para bromophenyl isopropyl methylamines
CH524568A (en) * 1965-02-08 1972-06-30 Chinoin Gyogyszer Es Vegyeszet N-(Lower alkyl)-phenylisopropylamines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH524568A (en) * 1965-02-08 1972-06-30 Chinoin Gyogyszer Es Vegyeszet N-(Lower alkyl)-phenylisopropylamines
US3485874A (en) * 1966-05-04 1969-12-23 Chinoin Gyogyszer Es Vegyeszet Ortho and para bromophenyl isopropyl methylamines

Also Published As

Publication number Publication date
MD69B1 (en) 1994-10-31
LV5218A3 (en) 1993-10-10
LT2176B (en) 1993-10-15

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Legal Events

Date Code Title Description
FG4A Patent for invention issued
IF99 Valid patent on 19990615

Free format text: EXPIRES: 20050530