MD69C2 - The method of obtaining of N (2-(4-fluorenephenyl 1-methyl)ethyl-N-methyl-N-propinelamine's - Google Patents
The method of obtaining of N (2-(4-fluorenephenyl 1-methyl)ethyl-N-methyl-N-propinelamine'sInfo
- Publication number
- MD69C2 MD69C2 MD94-0139A MD940139A MD69C2 MD 69 C2 MD69 C2 MD 69C2 MD 940139 A MD940139 A MD 940139A MD 69 C2 MD69 C2 MD 69C2
- Authority
- MD
- Moldova
- Prior art keywords
- methyl
- obtaining
- propinelamine
- ethyl
- fluorenephenyl
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The method of obtaining of N[2-(4-fluorene phenyl 1-methyl]ethyl-Nmethyl-N-propinelamine's. The invention relates to amines, namely to the proceeding of obtaining N[2-(4-fluorenephenyl 1-methyl]ethyl-N-methyl-N-propinelamine's or of the admissible salts in pharmacology under the form of racemase or of the optic activ isomer which possess a antidepressing activity that may be used in medicine. The aim of the invention consist of obtaining the new compounds that are more active from this class. The synthesis is performed through reaction p-fluorenephenylacetone with amine, with the formula HNR, R2, where R1, 1H or propynil, R21H or methyl. Ketynine or oximine that are obtained are reduced in the case if R11H, it is propinelat and if R21H, it is methyliat. The final product are obtained under the form of a free base or of a pharmacologic salt admissed as a recemase or a activ optic isomer. The researches show that the new compounds are selected inhibitive very active of monoaminoxidore of B type and absorption inhibitive of tiraamines and biogen amines.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU842124A HU207282B (en) | 1984-05-31 | 1984-05-31 | Process for producing phenyl-alkyl-amine derivatives and pharmaceutical compositions containing them |
PCT/HU1985/000035 WO1985005617A1 (en) | 1984-05-31 | 1985-05-31 | Phenylisopropylamine derivative and its preparation |
SU864015073A SU1487810A3 (en) | 1984-05-31 | 1986-01-30 | Method of producing n-/2-(4-fluorophenyl))-1-methyl/-ethyl-n-methyl-n-propylniamine |
Publications (2)
Publication Number | Publication Date |
---|---|
MD69B1 MD69B1 (en) | 1994-10-31 |
MD69C2 true MD69C2 (en) | 1995-01-31 |
Family
ID=26317470
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MD94-0139A MD69C2 (en) | 1984-05-31 | 1994-04-21 | The method of obtaining of N (2-(4-fluorenephenyl 1-methyl)ethyl-N-methyl-N-propinelamine's |
Country Status (3)
Country | Link |
---|---|
LT (1) | LT2176B (en) |
LV (1) | LV5218A3 (en) |
MD (1) | MD69C2 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3485874A (en) * | 1966-05-04 | 1969-12-23 | Chinoin Gyogyszer Es Vegyeszet | Ortho and para bromophenyl isopropyl methylamines |
CH524568A (en) * | 1965-02-08 | 1972-06-30 | Chinoin Gyogyszer Es Vegyeszet | N-(Lower alkyl)-phenylisopropylamines |
-
1993
- 1993-06-08 LV LV930487A patent/LV5218A3/en unknown
- 1993-06-12 LT LTRP650A patent/LT2176B/en not_active IP Right Cessation
-
1994
- 1994-04-21 MD MD94-0139A patent/MD69C2/en active IP Right Grant
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH524568A (en) * | 1965-02-08 | 1972-06-30 | Chinoin Gyogyszer Es Vegyeszet | N-(Lower alkyl)-phenylisopropylamines |
US3485874A (en) * | 1966-05-04 | 1969-12-23 | Chinoin Gyogyszer Es Vegyeszet | Ortho and para bromophenyl isopropyl methylamines |
Also Published As
Publication number | Publication date |
---|---|
MD69B1 (en) | 1994-10-31 |
LT2176B (en) | 1993-10-15 |
LV5218A3 (en) | 1993-10-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG4A | Patent for invention issued | ||
IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20050530 |