MD4485C1 - Process for producing 9-butylamino-3,3-dimethyl-3,4-dihydroacridine-1(2H)-one hydrochloride - Google Patents

Process for producing 9-butylamino-3,3-dimethyl-3,4-dihydroacridine-1(2H)-one hydrochloride

Info

Publication number
MD4485C1
MD4485C1 MDA20150115A MD20150115A MD4485C1 MD 4485 C1 MD4485 C1 MD 4485C1 MD A20150115 A MDA20150115 A MD A20150115A MD 20150115 A MD20150115 A MD 20150115A MD 4485 C1 MD4485 C1 MD 4485C1
Authority
MD
Moldova
Prior art keywords
dimethyl
dihydroacridine
producing
hydrochloride
butylamino
Prior art date
Application number
MDA20150115A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD4485B1 (en
MD20150115A0 (en
Inventor
Софья Яковлевна Скачилова
Николай Михайлович Митрохин
Original Assignee
Jsc Nizhpharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jsc Nizhpharm filed Critical Jsc Nizhpharm
Publication of MD20150115A0 publication Critical patent/MD20150115A0/en
Publication of MD4485B1 publication Critical patent/MD4485B1/en
Publication of MD4485C1 publication Critical patent/MD4485C1/en

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  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to chemical and pharmaceutical industry and concerns a process for producing 9-aminoacridine derivative, namely 9-butylamino-3,3-dimethyl-3,4-dihydroacridine-1(2H)-one hydrochloride.The process, according to the invention, comprises the steps of interaction of the nitrile of anthranilic acid with dimedone, cyclization of the resulting substituted 2-[(5,5-dimethyl-3-oxacyclohex-1-enyl)amino]benzonitrile hydrochloride and alkylation of 9-amino-3,3-dimethyl-3,4-dihydroacridine-1(H)-one. The process for producing intermediate compounds is carried out in a medium of alkylbenzenes.The process allows of obtaining a product with a high yield.
MDA20150115A 2014-12-10 2015-11-16 Process for producing 9-butylamino-3,3-dimethyl-3,4-dihydroacridine-1(2H)-one hydrochloride MD4485C1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2014150132/04A RU2567388C1 (en) 2014-12-10 2014-12-10 Method to produce 9-butylamino-3,3-dimethyl-3,4-dihydroacridin-1(2h)-on hydrochloride

Publications (3)

Publication Number Publication Date
MD20150115A0 MD20150115A0 (en) 2016-02-29
MD4485B1 MD4485B1 (en) 2017-05-31
MD4485C1 true MD4485C1 (en) 2017-12-31

Family

ID=54537009

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20150115A MD4485C1 (en) 2014-12-10 2015-11-16 Process for producing 9-butylamino-3,3-dimethyl-3,4-dihydroacridine-1(2H)-one hydrochloride

Country Status (3)

Country Link
EA (1) EA201501038A1 (en)
MD (1) MD4485C1 (en)
RU (1) RU2567388C1 (en)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0179383A2 (en) * 1984-10-25 1986-04-30 Hoechst-Roussel Pharmaceuticals Incorporated 9-Amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds, a process for their preparation and their use as medicaments
US4695573A (en) * 1984-10-25 1987-09-22 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
EP0268871A1 (en) * 1986-10-31 1988-06-01 Sumitomo Pharmaceuticals Company, Limited Quinoline derivatives
EP0282959A2 (en) * 1987-03-17 1988-09-21 Hoechst-Roussel Pharmaceuticals Incorporated Substituted 9-amino-tetrahydro-acridines and related compounds, a process for their preparation and their use as medicaments
EP0371388A2 (en) * 1988-11-28 1990-06-06 Fujisawa Pharmaceutical Co., Ltd. Acridine derivatives
US5053513A (en) * 1990-03-29 1991-10-01 Hoechst-Roussel Pharmaceuticals Incorporated Method of reducing a carbonyl containing acridine
RU2017730C1 (en) * 1990-09-17 1994-08-15 Химический факультет МГУ им.М.В.Ломоносова Method of 6-nitro-9-amino-2-ethoxyacridine synthesis
RU2024509C1 (en) * 1991-05-07 1994-12-15 Всероссийский научный центр по безопасности биологически активных веществ Derivatives of 9-aminoacridine or their salts with organic or inorganic acids showing psychotropic, antiamnestic and lipid-regulating activity

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0179383A2 (en) * 1984-10-25 1986-04-30 Hoechst-Roussel Pharmaceuticals Incorporated 9-Amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds, a process for their preparation and their use as medicaments
US4695573A (en) * 1984-10-25 1987-09-22 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
EP0268871A1 (en) * 1986-10-31 1988-06-01 Sumitomo Pharmaceuticals Company, Limited Quinoline derivatives
EP0282959A2 (en) * 1987-03-17 1988-09-21 Hoechst-Roussel Pharmaceuticals Incorporated Substituted 9-amino-tetrahydro-acridines and related compounds, a process for their preparation and their use as medicaments
EP0371388A2 (en) * 1988-11-28 1990-06-06 Fujisawa Pharmaceutical Co., Ltd. Acridine derivatives
US5053513A (en) * 1990-03-29 1991-10-01 Hoechst-Roussel Pharmaceuticals Incorporated Method of reducing a carbonyl containing acridine
RU2017730C1 (en) * 1990-09-17 1994-08-15 Химический факультет МГУ им.М.В.Ломоносова Method of 6-nitro-9-amino-2-ethoxyacridine synthesis
RU2024509C1 (en) * 1991-05-07 1994-12-15 Всероссийский научный центр по безопасности биологически активных веществ Derivatives of 9-aminoacridine or their salts with organic or inorganic acids showing psychotropic, antiamnestic and lipid-regulating activity

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Деева Э. Г. Сравнительный анализ противогриппозной активности соединений ряда азоло-азинов, флуоренов и акридонов. Автореферат на соискание ученой степени канд. мед. наук, СПб., 2000, p. 16-22 *
Ершов Ф.И., Чижов Н.П., Тазулахова Э.Б. Противовирусные средства, СПб., 1993, p. 11-15 *

Also Published As

Publication number Publication date
MD4485B1 (en) 2017-05-31
RU2567388C1 (en) 2015-11-10
EA201501038A1 (en) 2016-06-30
MD20150115A0 (en) 2016-02-29

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Legal Events

Date Code Title Description
FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees