MD4485C1 - Process for producing 9-butylamino-3,3-dimethyl-3,4-dihydroacridine-1(2H)-one hydrochloride - Google Patents
Process for producing 9-butylamino-3,3-dimethyl-3,4-dihydroacridine-1(2H)-one hydrochlorideInfo
- Publication number
- MD4485C1 MD4485C1 MDA20150115A MD20150115A MD4485C1 MD 4485 C1 MD4485 C1 MD 4485C1 MD A20150115 A MDA20150115 A MD A20150115A MD 20150115 A MD20150115 A MD 20150115A MD 4485 C1 MD4485 C1 MD 4485C1
- Authority
- MD
- Moldova
- Prior art keywords
- dimethyl
- dihydroacridine
- producing
- hydrochloride
- butylamino
- Prior art date
Links
Landscapes
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to chemical and pharmaceutical industry and concerns a process for producing 9-aminoacridine derivative, namely 9-butylamino-3,3-dimethyl-3,4-dihydroacridine-1(2H)-one hydrochloride.The process, according to the invention, comprises the steps of interaction of the nitrile of anthranilic acid with dimedone, cyclization of the resulting substituted 2-[(5,5-dimethyl-3-oxacyclohex-1-enyl)amino]benzonitrile hydrochloride and alkylation of 9-amino-3,3-dimethyl-3,4-dihydroacridine-1(H)-one. The process for producing intermediate compounds is carried out in a medium of alkylbenzenes.The process allows of obtaining a product with a high yield.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2014150132/04A RU2567388C1 (en) | 2014-12-10 | 2014-12-10 | Method to produce 9-butylamino-3,3-dimethyl-3,4-dihydroacridin-1(2h)-on hydrochloride |
Publications (3)
Publication Number | Publication Date |
---|---|
MD20150115A0 MD20150115A0 (en) | 2016-02-29 |
MD4485B1 MD4485B1 (en) | 2017-05-31 |
MD4485C1 true MD4485C1 (en) | 2017-12-31 |
Family
ID=54537009
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20150115A MD4485C1 (en) | 2014-12-10 | 2015-11-16 | Process for producing 9-butylamino-3,3-dimethyl-3,4-dihydroacridine-1(2H)-one hydrochloride |
Country Status (3)
Country | Link |
---|---|
EA (1) | EA201501038A1 (en) |
MD (1) | MD4485C1 (en) |
RU (1) | RU2567388C1 (en) |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0179383A2 (en) * | 1984-10-25 | 1986-04-30 | Hoechst-Roussel Pharmaceuticals Incorporated | 9-Amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds, a process for their preparation and their use as medicaments |
US4695573A (en) * | 1984-10-25 | 1987-09-22 | Hoechst-Roussel Pharmaceuticals Inc. | 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds |
EP0268871A1 (en) * | 1986-10-31 | 1988-06-01 | Sumitomo Pharmaceuticals Company, Limited | Quinoline derivatives |
EP0282959A2 (en) * | 1987-03-17 | 1988-09-21 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted 9-amino-tetrahydro-acridines and related compounds, a process for their preparation and their use as medicaments |
EP0371388A2 (en) * | 1988-11-28 | 1990-06-06 | Fujisawa Pharmaceutical Co., Ltd. | Acridine derivatives |
US5053513A (en) * | 1990-03-29 | 1991-10-01 | Hoechst-Roussel Pharmaceuticals Incorporated | Method of reducing a carbonyl containing acridine |
RU2017730C1 (en) * | 1990-09-17 | 1994-08-15 | Химический факультет МГУ им.М.В.Ломоносова | Method of 6-nitro-9-amino-2-ethoxyacridine synthesis |
RU2024509C1 (en) * | 1991-05-07 | 1994-12-15 | Всероссийский научный центр по безопасности биологически активных веществ | Derivatives of 9-aminoacridine or their salts with organic or inorganic acids showing psychotropic, antiamnestic and lipid-regulating activity |
-
2014
- 2014-12-10 RU RU2014150132/04A patent/RU2567388C1/en not_active IP Right Cessation
-
2015
- 2015-11-16 MD MDA20150115A patent/MD4485C1/en not_active IP Right Cessation
- 2015-11-19 EA EA201501038A patent/EA201501038A1/en unknown
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0179383A2 (en) * | 1984-10-25 | 1986-04-30 | Hoechst-Roussel Pharmaceuticals Incorporated | 9-Amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds, a process for their preparation and their use as medicaments |
US4695573A (en) * | 1984-10-25 | 1987-09-22 | Hoechst-Roussel Pharmaceuticals Inc. | 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds |
EP0268871A1 (en) * | 1986-10-31 | 1988-06-01 | Sumitomo Pharmaceuticals Company, Limited | Quinoline derivatives |
EP0282959A2 (en) * | 1987-03-17 | 1988-09-21 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted 9-amino-tetrahydro-acridines and related compounds, a process for their preparation and their use as medicaments |
EP0371388A2 (en) * | 1988-11-28 | 1990-06-06 | Fujisawa Pharmaceutical Co., Ltd. | Acridine derivatives |
US5053513A (en) * | 1990-03-29 | 1991-10-01 | Hoechst-Roussel Pharmaceuticals Incorporated | Method of reducing a carbonyl containing acridine |
RU2017730C1 (en) * | 1990-09-17 | 1994-08-15 | Химический факультет МГУ им.М.В.Ломоносова | Method of 6-nitro-9-amino-2-ethoxyacridine synthesis |
RU2024509C1 (en) * | 1991-05-07 | 1994-12-15 | Всероссийский научный центр по безопасности биологически активных веществ | Derivatives of 9-aminoacridine or their salts with organic or inorganic acids showing psychotropic, antiamnestic and lipid-regulating activity |
Non-Patent Citations (2)
Title |
---|
Деева Э. Г. Сравнительный анализ противогриппозной активности соединений ряда азоло-азинов, флуоренов и акридонов. Автореферат на соискание ученой степени канд. мед. наук, СПб., 2000, p. 16-22 * |
Ершов Ф.И., Чижов Н.П., Тазулахова Э.Б. Противовирусные средства, СПб., 1993, p. 11-15 * |
Also Published As
Publication number | Publication date |
---|---|
MD4485B1 (en) | 2017-05-31 |
RU2567388C1 (en) | 2015-11-10 |
EA201501038A1 (en) | 2016-06-30 |
MD20150115A0 (en) | 2016-02-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG4A | Patent for invention issued | ||
KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
MM4A | Patent for invention definitely lapsed due to non-payment of fees |