MD425C2 - Process for 23-(C1-C6 alkyloximes)-LL-F28249 preparation - Google Patents

Process for 23-(C1-C6 alkyloximes)-LL-F28249 preparation

Info

Publication number
MD425C2
MD425C2 MD95-0307A MD950307A MD425C2 MD 425 C2 MD425 C2 MD 425C2 MD 950307 A MD950307 A MD 950307A MD 425 C2 MD425 C2 MD 425C2
Authority
MD
Moldova
Prior art keywords
alkyloximes
preparation
compositions
crystallic
oxydation
Prior art date
Application number
MD95-0307A
Other languages
Romanian (ro)
Russian (ru)
Inventor
Roy Maulding Donald
Kumar Anil
Original Assignee
Эмерикэн Сайенэмид Компэни
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эмерикэн Сайенэмид Компэни filed Critical Эмерикэн Сайенэмид Компэни
Publication of MD425C2 publication Critical patent/MD425C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Steroid Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Cosmetics (AREA)
  • Liquid Crystal Substances (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Lubricants (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

It is described the process preparation of the 23-(C1-C6 alkyloximes)-LL-F28249 compositions by means of crystallic compositions 5-0-n-nitrobenzoyl LL-F28249 oxydation.
MD95-0307A 1989-09-11 1994-07-12 Process for 23-(C1-C6 alkyloximes)-LL-F28249 preparation MD425C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/405,793 US4988824A (en) 1989-09-11 1989-09-11 Process for the preparation of 23-(C1-C6 alkyloxime)-LL-F28249 compounds

Publications (1)

Publication Number Publication Date
MD425C2 true MD425C2 (en) 1997-04-30

Family

ID=23605260

Family Applications (1)

Application Number Title Priority Date Filing Date
MD95-0307A MD425C2 (en) 1989-09-11 1994-07-12 Process for 23-(C1-C6 alkyloximes)-LL-F28249 preparation

Country Status (28)

Country Link
US (1) US4988824A (en)
EP (1) EP0421081B1 (en)
JP (1) JP2939312B2 (en)
KR (1) KR0160977B1 (en)
CN (1) CN1028428C (en)
AT (1) ATE107650T1 (en)
AU (1) AU634579B2 (en)
BG (1) BG60620B1 (en)
BR (1) BR9004493A (en)
CA (1) CA2024919C (en)
DE (1) DE69010129T2 (en)
DK (1) DK0421081T3 (en)
ES (1) ES2057291T3 (en)
GE (1) GEP19981003B (en)
HK (1) HK1000095A1 (en)
HU (1) HU206721B (en)
IE (1) IE66030B1 (en)
IL (1) IL95303A (en)
LV (1) LV10503B (en)
MD (1) MD425C2 (en)
NZ (1) NZ235151A (en)
PL (1) PL165332B1 (en)
PT (1) PT95242B (en)
RU (1) RU2030416C1 (en)
SI (1) SI9011711A (en)
UA (1) UA26907C2 (en)
YU (1) YU47520B (en)
ZA (1) ZA907186B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5439924A (en) * 1991-12-23 1995-08-08 Virbac, Inc. Systemic control of parasites
AU660205B2 (en) 1991-12-23 1995-06-15 Virbac, Inc Systemic control of parasites
US5478951A (en) * 1994-06-22 1995-12-26 American Cyanamid Company Method for the purification of 23-E isomers of 23-imino derivatives of LL-F28249 compounds
AU695656B2 (en) * 1995-02-24 1998-08-20 Novartis Tiergesundheit Ag Composition for controlling parasites
ES2174027T3 (en) * 1995-06-30 2002-11-01 American Cyanamid Co STABLE COMPOSITIONS CONTAINING MACROLIDES AND MACROLIDES COMBINED WITH VACCINES.
US6495591B1 (en) 1997-10-02 2002-12-17 Essential Therapeutics, Inc. Fungal efflux pump inhibitors
US6762327B2 (en) * 2002-04-29 2004-07-13 Wyeth Selective oxidation process with enhanced safety
US7348417B2 (en) * 2003-08-07 2008-03-25 Wyeth Method of purifying moxidectin through crystallization
NZ548934A (en) * 2006-05-08 2007-01-26 Wyeth Corp Process for preparing moxidectin
AU2006203459B2 (en) * 2006-05-08 2010-02-25 Wyeth Intermediates and processes using them
NZ548936A (en) * 2006-06-22 2007-02-23 Wyeth Corp Selective oxidation of LL-F28249-alpha using o-iodoxybenzoic acid
PT3351546T (en) 2011-12-02 2024-03-07 Boehringer Ingelheim Vetmedica Gmbh Long-acting injectable moxidectin formulations
CN104277050B (en) * 2013-07-04 2016-05-04 北大方正集团有限公司 A kind of method of preparing moxidectin
CN104017001B (en) * 2014-06-18 2016-01-13 大连九信生物化工科技有限公司 A kind of method of chemosynthesis mosictin
CN104292239A (en) * 2014-09-30 2015-01-21 大连九信生物化工科技有限公司 Method for removing by-product dimethyl sulfide in moxidectin production process
CN104628740B (en) * 2015-02-13 2017-06-16 河北圣雪大成制药有限责任公司 A kind of chemical synthesis and the method for purifying moxidectin
CN104860961B (en) * 2015-04-10 2017-08-04 新宇药业股份有限公司 One kind prepares 5 oxygen（P-nitrophenyl formyl）The method of nimoctin
CN105085540B (en) * 2015-08-12 2017-07-07 内蒙古佳瑞米精细化工有限公司 A kind of method for preparing high-content nemoctin
CN114591347B (en) * 2022-03-29 2023-03-24 河北美荷药业有限公司 Moxidectin intermediate and preparation method thereof, and preparation method of moxidectin

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0307224A2 (en) * 1987-09-11 1989-03-15 American Cyanamid Company Macrolide compounds
US4900758A (en) * 1989-05-11 1990-02-13 Ici Americas Inc. Novel insecticides
US4916154A (en) * 1986-09-12 1990-04-10 American Cyanamid Company 23-Imino derivatives of LL-F28249 compounds
GB2192630B (en) * 1986-06-06 1990-05-23 Glaxo Group Ltd Macrolide compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201861A (en) * 1977-10-03 1980-05-06 Merck & Co., Inc. Acyl derivatives of C-076 compounds
ES8802229A1 (en) * 1985-04-30 1988-04-16 Glaxo Group Ltd Macrolide antibiotics and their preparation
DE3750355T2 (en) * 1986-09-12 1995-04-06 American Cyanamid Co 23-Oxo (keto) and 23-imino derivatives of LL-F28249 compounds.
US4855317A (en) * 1987-03-06 1989-08-08 Ciba-Geigy Corporation Insecticides and parasiticides
GB8721377D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical compounds
BR8902167A (en) * 1988-05-10 1990-01-02 American Cyanamid Co PROCESS FOR THE PREPARATION OF MACROLIDED COMPOUNDS, PESTICID COMPOSITES AND PROCESS FOR PEST CONTROL
GB8813150D0 (en) * 1988-06-03 1988-07-06 American Cyanamid Co Chemical compounds
ATE130006T1 (en) * 1989-09-11 1995-11-15 American Cyanamid Co 13-ALKYL-23-IMINO AND 13-HALO-23-IMINO DERIVATIVES OF LL-F28249 COMPOUNDS AND THEIR USE AS ENDO- AND ECTOPARASITICIDES, INSECTICIDES, ACARICIDES AND NEMATOCIDAL AGENTS.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2192630B (en) * 1986-06-06 1990-05-23 Glaxo Group Ltd Macrolide compounds
US4916154A (en) * 1986-09-12 1990-04-10 American Cyanamid Company 23-Imino derivatives of LL-F28249 compounds
EP0307224A2 (en) * 1987-09-11 1989-03-15 American Cyanamid Company Macrolide compounds
US4900758A (en) * 1989-05-11 1990-02-13 Ici Americas Inc. Novel insecticides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JACS, 89, 1967, I.D. Albright et al., p. 2416. *

Also Published As

Publication number Publication date
PT95242A (en) 1991-05-22
ZA907186B (en) 1991-06-26
HUT55019A (en) 1991-04-29
BG60620B1 (en) 1995-10-31
NZ235151A (en) 1992-11-25
PL165332B1 (en) 1994-12-30
IL95303A (en) 1994-11-28
GEP19981003B (en) 1998-10-27
KR910006490A (en) 1991-04-29
CA2024919C (en) 2001-12-11
LV10503B (en) 1996-04-20
RU2030416C1 (en) 1995-03-10
CN1051043A (en) 1991-05-01
YU47520B (en) 1995-10-03
KR0160977B1 (en) 1998-12-01
IE903273A1 (en) 1991-03-27
DE69010129T2 (en) 1995-01-26
EP0421081A1 (en) 1991-04-10
PT95242B (en) 1997-06-30
AU6236290A (en) 1991-03-14
US4988824A (en) 1991-01-29
IE66030B1 (en) 1995-11-29
BG92810A (en) 1993-12-24
HK1000095A1 (en) 1997-11-21
JPH03141283A (en) 1991-06-17
ATE107650T1 (en) 1994-07-15
CN1028428C (en) 1995-05-17
CA2024919A1 (en) 1991-03-12
DE69010129D1 (en) 1994-07-28
HU206721B (en) 1992-12-28
IL95303A0 (en) 1991-06-30
EP0421081B1 (en) 1994-06-22
DK0421081T3 (en) 1994-07-25
BR9004493A (en) 1991-09-10
PL286824A1 (en) 1991-08-12
YU171190A (en) 1992-07-20
AU634579B2 (en) 1993-02-25
UA26907C2 (en) 1999-12-29
HU905842D0 (en) 1991-03-28
LV10503A (en) 1995-02-20
SI9011711A (en) 1998-02-28
ES2057291T3 (en) 1994-10-16
JP2939312B2 (en) 1999-08-25

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