MD4125B1 - 1,3,4-Oxadiazole compounds with antituberculous properties containing monosubstituted thiourea - Google Patents
1,3,4-Oxadiazole compounds with antituberculous properties containing monosubstituted thiourea Download PDFInfo
- Publication number
- MD4125B1 MD4125B1 MDA20100103A MD20100103A MD4125B1 MD 4125 B1 MD4125 B1 MD 4125B1 MD A20100103 A MDA20100103 A MD A20100103A MD 20100103 A MD20100103 A MD 20100103A MD 4125 B1 MD4125 B1 MD 4125B1
- Authority
- MD
- Moldova
- Prior art keywords
- antituberculous
- compounds
- oxadiazole compounds
- properties
- containing monosubstituted
- Prior art date
Links
- -1 monosubstituted thiourea Chemical class 0.000 title abstract 4
- 150000005072 1,3,4-oxadiazoles Chemical class 0.000 title abstract 2
- 230000002365 anti-tubercular Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 abstract 1
- 238000005915 ammonolysis reaction Methods 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000009036 growth inhibition Effects 0.000 abstract 1
- 238000006698 hydrazinolysis reaction Methods 0.000 abstract 1
- ZBKFYXZXZJPWNQ-UHFFFAOYSA-N isothiocyanate group Chemical group [N-]=C=S ZBKFYXZXZJPWNQ-UHFFFAOYSA-N 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 238000006177 thiolation reaction Methods 0.000 abstract 1
- KUAZQDVKQLNFPE-UHFFFAOYSA-N thiram Chemical compound CN(C)C(=S)SSC(=S)N(C)C KUAZQDVKQLNFPE-UHFFFAOYSA-N 0.000 abstract 1
- 229960002447 thiram Drugs 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20100103A MD4125C1 (ro) | 2010-09-17 | 2010-09-17 | Compuşi 1,3,4-oxadiazolici cu proprietăţi antituberculoase conţinând tiouree monosubstituită |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20100103A MD4125C1 (ro) | 2010-09-17 | 2010-09-17 | Compuşi 1,3,4-oxadiazolici cu proprietăţi antituberculoase conţinând tiouree monosubstituită |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD4125B1 true MD4125B1 (en) | 2011-08-31 |
| MD4125C1 MD4125C1 (ro) | 2012-03-31 |
Family
ID=45815251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20100103A MD4125C1 (ro) | 2010-09-17 | 2010-09-17 | Compuşi 1,3,4-oxadiazolici cu proprietăţi antituberculoase conţinând tiouree monosubstituită |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD4125C1 (mo) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD4404C1 (ro) * | 2015-03-18 | 2016-09-30 | Институт Химии Академии Наук Молдовы | Compusul 2-(propiltio)-5H-[1,3,4]tiadiazolo[2,3-b]chinazolin-5-onă, care manifestă activitate antituberculoasă şi procedeu de sinteză a acestuia |
| CZ306408B6 (cs) * | 2014-12-11 | 2017-01-11 | Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové | Dinitrofenyloxadiazol nebo -triazol, jeho použití a farmaceutický přípravek ho obsahující |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH319063A (de) * | 1952-10-10 | 1957-01-31 | Bayer Ag | Verfahren zur Herstellung von neuen Oxdiazolon-Derivaten |
| GB925911A (en) * | 1960-07-28 | 1963-05-15 | Ed Geistlich Sohne A G | Antitubercular pharmaceutical compositions |
| MD613G2 (ro) * | 1994-02-24 | 1997-06-30 | Государственный Университет Молд0 | Procedeu de obţinere a 2-mercapto-1,3,4-oxadiazolilor |
| JPH07258234A (ja) * | 1994-03-17 | 1995-10-09 | Shiratori Seiyaku Kk | １，３，４−オキサジアゾール−２（３ｈ）−チオン類の製造法 |
| MD4009C2 (ro) * | 2008-07-15 | 2010-08-31 | Институт Химии Академии Наук Молдовы | Utilizarea 1-metil-4-(N-metilaminobutil-4)-β-carbolinei în calitate de remediu antituberculos |
-
2010
- 2010-09-17 MD MDA20100103A patent/MD4125C1/ro not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ306408B6 (cs) * | 2014-12-11 | 2017-01-11 | Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové | Dinitrofenyloxadiazol nebo -triazol, jeho použití a farmaceutický přípravek ho obsahující |
| MD4404C1 (ro) * | 2015-03-18 | 2016-09-30 | Институт Химии Академии Наук Молдовы | Compusul 2-(propiltio)-5H-[1,3,4]tiadiazolo[2,3-b]chinazolin-5-onă, care manifestă activitate antituberculoasă şi procedeu de sinteză a acestuia |
Also Published As
| Publication number | Publication date |
|---|---|
| MD4125C1 (ro) | 2012-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
| MM4A | Patent for invention definitely lapsed due to non-payment of fees |