MD4077C1 - Process for obtaining N, N-dimethylthioureidobenzoic acids - Google Patents

Process for obtaining N, N-dimethylthioureidobenzoic acids

Info

Publication number
MD4077C1
MD4077C1 MDA20100005A MD20100005A MD4077C1 MD 4077 C1 MD4077 C1 MD 4077C1 MD A20100005 A MDA20100005 A MD A20100005A MD 20100005 A MD20100005 A MD 20100005A MD 4077 C1 MD4077 C1 MD 4077C1
Authority
MD
Moldova
Prior art keywords
dimethylthioureidobenzoic
acids
obtaining
reaction
acidulation
Prior art date
Application number
MDA20100005A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD4077B1 (en
Inventor
Никанор БАРБЭ
Галина ДРАГАЛИНА
Анна ПОПУШОЙ
Виорел ПРИСАКАРЬ
Original Assignee
Государственный Университет Молд0
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Государственный Университет Молд0 filed Critical Государственный Университет Молд0
Priority to MDA20100005A priority Critical patent/MD4077C1/en
Publication of MD4077B1 publication Critical patent/MD4077B1/en
Publication of MD4077C1 publication Critical patent/MD4077C1/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to processes for producing organic compounds, in particular to a process for obtaining N, N-dimethylthioureidobenzoic acids, which can be used as fungicides, nematocides, plant growth regulators or in organic synthesis.The process, according to the invention, includes the interaction of a substituted or unsubstituted aminobenzoic acid with tetramethylthiuram when heated in water and aqueous solution of dimethylamine as activator, at an initial molar ratio of reagents of 1:(0.75...1):(0.5...1) and the temperature of 65...80°C, monitoring of reaction by the method of thin layer chromatography, distillation of the formed carbon disulphide, alkalinization of the residue to pH=9, filtration of sulfur and other impurities, acidulation of filtrate to pH=2...3 and isolation of the reaction product by crystallization in the cold.
MDA20100005A 2010-01-18 2010-01-18 Process for obtaining N, N-dimethylthioureidobenzoic acids MD4077C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20100005A MD4077C1 (en) 2010-01-18 2010-01-18 Process for obtaining N, N-dimethylthioureidobenzoic acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20100005A MD4077C1 (en) 2010-01-18 2010-01-18 Process for obtaining N, N-dimethylthioureidobenzoic acids

Publications (2)

Publication Number Publication Date
MD4077B1 MD4077B1 (en) 2010-11-30
MD4077C1 true MD4077C1 (en) 2011-07-31

Family

ID=43569099

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20100005A MD4077C1 (en) 2010-01-18 2010-01-18 Process for obtaining N, N-dimethylthioureidobenzoic acids

Country Status (1)

Country Link
MD (1) MD4077C1 (en)

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1349956A (en) * 1970-06-23 1974-04-10 Sipcam Spa Fungicidal compositions and a process for their preparation
SU1648948A1 (en) * 1989-03-21 1991-05-15 Кишиневский Сельскохозяйственный Институт Им.М.В.Фрунзе Method for obtaining of 2-mercaptobenzooxasoles
DE4229235A1 (en) * 1992-09-02 1994-03-03 Bitterfeld Wolfen Chemie Prepn of 6-chloro-2-mercapto-benzoxazide - by reaction of 5-chloro-2-aminophenol with carbon di:sulphide in aq soln
MD613G2 (en) * 1994-02-24 1997-06-30 Государственный Университет Молд0 Process for 2 - mercapto - 1,3,4 - oxadiasols preparation
MD943G2 (en) * 1997-07-10 1999-02-28 Государственный Университет Молд0 Process for obtaining isothiocyanate benzoic acids
MD956G2 (en) * 1997-07-10 1999-03-31 Государственный Университет Молд0 Process for obtaining N-carboxyaryl-N',N'-dimethylthioureas
MD1106G2 (en) * 1998-07-09 1999-10-31 Государственный Университет Молд0 4-(N-thioureido)styrene oligomers for polymers stabilization and process for preparation thereof
MD1104G2 (en) * 1998-07-09 1999-10-31 Государственный Университет Молд0 Process for preparation of 5-N,N-dimethylthioureido-2-mercaptobenzoxazoles
MD1275G2 (en) * 1999-04-16 2000-02-29 Государственный Университет Молд0 Oligo-5-vinyl-2-mercaptobenzimidazole as antioxidant for polymeric materials
MD2985G2 (en) * 2004-10-04 2006-10-31 Государственный Университет Молд0 Process for isothiocyanatochalcone obtaining
CN101250146A (en) * 2008-03-25 2008-08-27 浙江大学 Method for synthesizing 3,3'-dimethylthio diphenylurea
MD3684G2 (en) * 2007-05-28 2009-03-31 Государственный Университет Молд0 Process for obtaining N,N-dialkyl thioureidoacetophenones

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1349956A (en) * 1970-06-23 1974-04-10 Sipcam Spa Fungicidal compositions and a process for their preparation
SU1648948A1 (en) * 1989-03-21 1991-05-15 Кишиневский Сельскохозяйственный Институт Им.М.В.Фрунзе Method for obtaining of 2-mercaptobenzooxasoles
DE4229235A1 (en) * 1992-09-02 1994-03-03 Bitterfeld Wolfen Chemie Prepn of 6-chloro-2-mercapto-benzoxazide - by reaction of 5-chloro-2-aminophenol with carbon di:sulphide in aq soln
MD613G2 (en) * 1994-02-24 1997-06-30 Государственный Университет Молд0 Process for 2 - mercapto - 1,3,4 - oxadiasols preparation
MD943G2 (en) * 1997-07-10 1999-02-28 Государственный Университет Молд0 Process for obtaining isothiocyanate benzoic acids
MD956G2 (en) * 1997-07-10 1999-03-31 Государственный Университет Молд0 Process for obtaining N-carboxyaryl-N',N'-dimethylthioureas
MD1106G2 (en) * 1998-07-09 1999-10-31 Государственный Университет Молд0 4-(N-thioureido)styrene oligomers for polymers stabilization and process for preparation thereof
MD1104G2 (en) * 1998-07-09 1999-10-31 Государственный Университет Молд0 Process for preparation of 5-N,N-dimethylthioureido-2-mercaptobenzoxazoles
MD1275G2 (en) * 1999-04-16 2000-02-29 Государственный Университет Молд0 Oligo-5-vinyl-2-mercaptobenzimidazole as antioxidant for polymeric materials
MD2985G2 (en) * 2004-10-04 2006-10-31 Государственный Университет Молд0 Process for isothiocyanatochalcone obtaining
MD3684G2 (en) * 2007-05-28 2009-03-31 Государственный Университет Молд0 Process for obtaining N,N-dialkyl thioureidoacetophenones
CN101250146A (en) * 2008-03-25 2008-08-27 浙江大学 Method for synthesizing 3,3'-dimethylthio diphenylurea

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Ribar A., Antos K., Kristian P., March J., Mavtova A. Isothiocyanates XVII. Synthesis of some substituted arilalkil thioureas. Chem. Zwest, 1966, 20(2), p. 826-833 *
Rybar A., Antos K., Kristian P., March J., Mavtova A. Isothiocyanates XVII. Synthesis of some substituted arilalkyl thioureas. Chem. Zwest, 1966, 20, *

Also Published As

Publication number Publication date
MD4077B1 (en) 2010-11-30

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FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees