MD121C2 - Process for obtaining of thienopyran derivatives - Google Patents

Process for obtaining of thienopyran derivatives

Info

Publication number
MD121C2
MD121C2 MD94-0124A MD940124A MD121C2 MD 121 C2 MD121 C2 MD 121C2 MD 940124 A MD940124 A MD 940124A MD 121 C2 MD121 C2 MD 121C2
Authority
MD
Moldova
Prior art keywords
formula
obtaining
reagent
compound
thienopyran derivatives
Prior art date
Application number
MD94-0124A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD121B1 (en
Inventor
Dieter Binder
Frantz Rovenszky
Hubert Ferber
Josef Weinberger
Original Assignee
Chemisch Pharmazeutische Forschungsgesellschaft M.B.H.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemisch Pharmazeutische Forschungsgesellschaft M.B.H. filed Critical Chemisch Pharmazeutische Forschungsgesellschaft M.B.H.
Publication of MD121B1 publication Critical patent/MD121B1/en
Publication of MD121C2 publication Critical patent/MD121C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Utilization: in medicine, in medicines for activation of the smooth musculature K-canals membranes. Summary of the invention: thienopyran derivatives of formula I:where n = 3 or 4. Reagent 1: a compound of formula 2, where X - Cl, Br or J. Reagent 2: a compound of formula 3, where n = 3 or 4. Process conditions: in the medium of an inert organic diluent in the presence of at least two equivalents of solid unnucleophilic base and in case of need the recemate obtained in such a way is divided into enantiomers.
MD94-0124A 1989-06-27 1994-05-24 Process for obtaining of thienopyran derivatives MD121C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT157389 1989-06-27
SU904830828A RU1833386C (en) 1989-06-27 1990-06-26 Method of synthesis of thienopyrane derivatives

Publications (2)

Publication Number Publication Date
MD121B1 MD121B1 (en) 1994-12-31
MD121C2 true MD121C2 (en) 1995-06-30

Family

ID=3516340

Family Applications (1)

Application Number Title Priority Date Filing Date
MD94-0124A MD121C2 (en) 1989-06-27 1994-05-24 Process for obtaining of thienopyran derivatives

Country Status (28)

Country Link
US (1) US5077307A (en)
EP (1) EP0405298B1 (en)
KR (1) KR910000743A (en)
CN (1) CN1025621C (en)
AT (1) ATE105559T1 (en)
AU (1) AU628995B2 (en)
CA (1) CA2019737A1 (en)
CZ (1) CZ280543B6 (en)
DD (1) DD295850A5 (en)
DE (1) DE59005666D1 (en)
DK (1) DK0405298T3 (en)
ES (1) ES2053015T3 (en)
FI (1) FI96312C (en)
HR (1) HRP940819A2 (en)
HU (1) HU204834B (en)
IE (1) IE63935B1 (en)
IL (1) IL94703A (en)
LT (1) LT3799B (en)
LV (1) LV10776A (en)
MD (1) MD121C2 (en)
NO (1) NO174423C (en)
NZ (1) NZ234084A (en)
PT (1) PT94487B (en)
RU (1) RU1833386C (en)
SK (1) SK278012B6 (en)
UA (1) UA15930A (en)
YU (1) YU124690A (en)
ZA (1) ZA904885B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD149Z5 (en) * 2009-09-17 2010-09-30 Сергей Чербарь Seal with polymer optical fibers
MD4034C2 (en) * 2009-11-03 2010-11-30 Сергей Чербарь Indicator seal for metrology equipment
MD4230C1 (en) * 2012-11-29 2013-12-31 Фёдор СЫРБУ Seal
MD861Z (en) * 2014-06-03 2015-07-31 Александр КОРЕНКОВ Seal
MD4534B1 (en) * 2017-03-03 2017-11-30 Сергей Чербарь Lockable rotor seal for metrological devices

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ230711A (en) * 1988-09-23 1990-10-26 Ortho Pharma Corp Substituted thienopyrans as antihypertensive agents
DE3925719A1 (en) * 1989-08-03 1991-02-07 Bayer Ag SUBSTITUTED THIENOPYRANONEES, PROCESS FOR THEIR PREPARATION AND THEIR USE FOR THE CONTROL OF PARASITES
NZ240933A (en) * 1990-12-21 1993-05-26 Ortho Pharma Corp Preparing enantiomerically pure thienopyran derivatives
GB9909792D0 (en) * 1998-12-04 1999-06-23 Cambridge Bioclinical Limited Potassium channel activators and their use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3274350D1 (en) * 1981-09-25 1987-01-08 Beecham Group Plc Pharmaceutically active benzopyran compounds
GB8308062D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds
DE3682331D1 (en) * 1985-06-08 1991-12-12 Beecham Group Plc PYRANO (3,2-C) PYRIDE DERIVATIVES, METHODS AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.
GB8613786D0 (en) * 1986-06-06 1986-07-09 Beecham Group Plc Active compounds
DE3881714D1 (en) * 1987-02-04 1993-07-22 Hoechst Ag ALKYL-SUBSTITUTED N-BENZOPYRANYLLACTAME, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AND PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS.
US4789525A (en) * 1987-06-22 1988-12-06 Eastman Kodak Company Analytical method and multilayer element for total ionic iron determination
NZ230711A (en) * 1988-09-23 1990-10-26 Ortho Pharma Corp Substituted thienopyrans as antihypertensive agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Brevet EP, nr.76075, Int.cl5. C 07 D 405 /04, 1983. *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD149Z5 (en) * 2009-09-17 2010-09-30 Сергей Чербарь Seal with polymer optical fibers
MD4034C2 (en) * 2009-11-03 2010-11-30 Сергей Чербарь Indicator seal for metrology equipment
MD4230C1 (en) * 2012-11-29 2013-12-31 Фёдор СЫРБУ Seal
MD861Z (en) * 2014-06-03 2015-07-31 Александр КОРЕНКОВ Seal
MD4534B1 (en) * 2017-03-03 2017-11-30 Сергей Чербарь Lockable rotor seal for metrological devices

Also Published As

Publication number Publication date
LV10776A (en) 1995-08-20
DD295850A5 (en) 1991-11-14
CZ280543B6 (en) 1996-02-14
ZA904885B (en) 1991-03-27
HUT55787A (en) 1991-06-28
ES2053015T3 (en) 1994-07-16
KR910000743A (en) 1991-01-30
IE902097A1 (en) 1991-01-02
CN1025621C (en) 1994-08-10
IL94703A (en) 1994-07-31
YU124690A (en) 1991-10-31
FI96312B (en) 1996-02-29
AU5778790A (en) 1991-01-03
NO902832L (en) 1990-12-28
LTIP1590A (en) 1995-06-26
AU628995B2 (en) 1992-09-24
CZ317290A3 (en) 1995-10-18
FI903172A0 (en) 1990-06-25
LT3799B (en) 1996-03-25
HU204834B (en) 1992-02-28
IE902097L (en) 1990-12-27
DE59005666D1 (en) 1994-06-16
HRP940819A2 (en) 1996-08-31
CA2019737A1 (en) 1990-12-27
US5077307A (en) 1991-12-31
HU903998D0 (en) 1990-11-28
FI96312C (en) 1996-06-10
SK317290A3 (en) 1995-10-11
NO902832D0 (en) 1990-06-26
RU1833386C (en) 1993-08-07
PT94487B (en) 1997-02-28
CN1048388A (en) 1991-01-09
EP0405298A1 (en) 1991-01-02
EP0405298B1 (en) 1994-05-11
PT94487A (en) 1991-02-08
DK0405298T3 (en) 1994-06-06
IL94703A0 (en) 1991-04-15
ATE105559T1 (en) 1994-05-15
SK278012B6 (en) 1995-10-11
MD121B1 (en) 1994-12-31
IE63935B1 (en) 1995-06-28
NO174423B (en) 1994-01-24
NO174423C (en) 1994-05-04
UA15930A (en) 1997-06-30
NZ234084A (en) 1992-03-26

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Legal Events

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1M4A Expiration of terms