MD1019Z - Method of treatment of inflammatory-destructive disorders of periodontitis - Google Patents
Method of treatment of inflammatory-destructive disorders of periodontitis Download PDFInfo
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- MD1019Z MD1019Z MDS20150091A MDS20150091A MD1019Z MD 1019 Z MD1019 Z MD 1019Z MD S20150091 A MDS20150091 A MD S20150091A MD S20150091 A MDS20150091 A MD S20150091A MD 1019 Z MD1019 Z MD 1019Z
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- ozone
- oil
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- ozonated
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- 238000000034 method Methods 0.000 title claims description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract description 3
- 201000001245 periodontitis Diseases 0.000 title description 4
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 claims abstract description 34
- 239000000203 mixture Substances 0.000 claims abstract description 17
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000000944 linseed oil Substances 0.000 claims abstract description 7
- 235000021388 linseed oil Nutrition 0.000 claims abstract description 7
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 7
- 239000001301 oxygen Substances 0.000 claims abstract description 7
- 208000005888 Periodontal Pocket Diseases 0.000 claims abstract description 6
- 239000010460 hemp oil Substances 0.000 claims abstract description 5
- 210000002455 dental arch Anatomy 0.000 claims abstract description 4
- 230000005587 bubbling Effects 0.000 claims description 4
- 208000028169 periodontal disease Diseases 0.000 claims description 3
- 239000003814 drug Substances 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
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- 235000021122 unsaturated fatty acids Nutrition 0.000 description 3
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 2
- 208000006558 Dental Calculus Diseases 0.000 description 2
- 208000003433 Gingival Pocket Diseases 0.000 description 2
- 235000011941 Tilia x europaea Nutrition 0.000 description 2
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- 210000000214 mouth Anatomy 0.000 description 2
- WURFKUQACINBSI-UHFFFAOYSA-M ozonide Chemical compound [O]O[O-] WURFKUQACINBSI-UHFFFAOYSA-M 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- RZYIPLSVRHWROD-UHFFFAOYSA-N 1,2,4-trioxolane Chemical class C1OCOO1 RZYIPLSVRHWROD-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 208000010266 Aggressive Periodontitis Diseases 0.000 description 1
- 206010006326 Breath odour Diseases 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010018286 Gingival pain Diseases 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- 208000001143 Periodontal Abscess Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
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- 239000013543 active substance Substances 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
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- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
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- 235000020778 linoleic acid Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
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- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Invenţia se referă la medicină, în special la stomatologie, şi poate fi folosită pentru tratamentul diverselor afecţiuni inflamator-distructive ale parodonţiului. The invention relates to medicine, in particular to dentistry, and can be used for the treatment of various inflammatory-destructive periodontal diseases.
Este cunoscută metoda de tratament al periodontitei cu ulei ozonat din olive sub formă de aplicaţii [1]. The method of treating periodontitis with ozonated olive oil in the form of applications is known [1].
Este de asemenea cunoscută metoda de tratament al afecţiunilor inflamatorii ale parodonţiului, care constă în aceea că substanţa medicamentoasă până la întrebuinţare se barbotează cu amestec de ozon şi oxigen timp de 1…2 ore, care conţine 2000…3000 µg/L de ozon, totodată în calitate de substanţă medicamentoasă se utilizează ulei vegetal, şi anume din olive, şi se administrează sub formă de aplicaţii câte 10 mL pe fiecare jumătate de maxilar sau instilaţii a câte 0,9…1,0 mL în fiecare pungă gingivală afectată timp de 6…8 zile [2]. The method of treating inflammatory periodontal diseases is also known, which consists in the fact that the medicinal substance is bubbled with a mixture of ozone and oxygen for 1…2 hours before use, which contains 2000…3000 µg/L of ozone, at the same time, vegetable oil is used as the medicinal substance, namely olive oil, and it is administered in the form of applications of 10 mL on each half of the jaw or instillations of 0.9…1.0 mL in each affected gingival pocket for 6…8 days [2].
Dezavantajul metodei menţionate constă în eficienţa terapeutică redusă, deoarece uleiul de olive reţine ozon în cantităţi medii şi puterea de acţiune a ozonidelor, de asemenea, este medie. The disadvantage of the mentioned method is its low therapeutic efficiency, because olive oil retains ozone in medium quantities and the power of action of ozonides is also medium.
Problema pe care o rezolvă prezenta invenţie este elaborarea unei metode de tratament pentru sporirea eficacităţii terapeutice, reducerea termenelor de tratament şi evitarea recidivelor. The problem solved by the present invention is the development of a treatment method to increase therapeutic efficacy, reduce treatment times and avoid relapses.
Esenţa invenţiei constă în aceea că pe arcadele dentare se aplică nişte gutiere dentare prefabricate cu un amestec medicamentos, timp de o oră pe zi sau cu o seringă se introduce în punga parodontală amestecul medicamentos o dată pe zi, timp de 5…8 zile, iar amestecul menţionat include ulei din seminţe de in 30…60% şi ulei din seminţe de cânepă 40…70%, şi în prealabil se barbotează cu un amestec de ozon şi oxigen, care conţine 40000 µg/L de ozon, cu un debit de 1 L/min, timp de 12…24 ore. The essence of the invention is that prefabricated dental trays with a medicinal mixture are applied to the dental arches for one hour a day or the medicinal mixture is introduced into the periodontal pocket with a syringe once a day for 5…8 days, and the said mixture includes 30…60% flaxseed oil and 40…70% hempseed oil, and is previously bubbled with a mixture of ozone and oxygen, which contains 40,000 µg/L of ozone, with a flow rate of 1 L/min, for 12…24 hours.
Rezultatul invenţiei constă în sporirea eficacităţii terapeutice, înlăturarea inflamaţiei ţesuturilor parodontale, stoparea resorbţiei ţesutului osos şi stimularea proprietăţilor de reparare şi regenerare a ţesuturilor. The result of the invention consists in increasing therapeutic efficacy, removing inflammation of periodontal tissues, stopping bone tissue resorption and stimulating tissue repair and regeneration properties.
Unul din factorii cei mai limitrofi în utilizarea ozonului este stabilitatea scăzută în condiţii naturale. O metodă de prelungire a acţiunii ozonului este dizolvarea lui în ulei vegetal. Procesul de barbotare a ozonului în ulei vegetal duce la formarea uleiului ozonat. Majoritatea uleiurilor vegetale conţin trigliceride în proporţie de 97…98%. Compoziţia de acizi graşi saturaţi şi nesaturaţi diferă în funcţie de originea şi natura lor. Proprietăţile benefice ale uleiurilor sunt atribuite, în mod special, cantităţii de acizi graşi nesaturaţi. One of the most limiting factors in the use of ozone is its low stability under natural conditions. A method of prolonging the action of ozone is its dissolution in vegetable oil. The process of bubbling ozone into vegetable oil leads to the formation of ozonated oil. Most vegetable oils contain triglycerides in a proportion of 97…98%. The composition of saturated and unsaturated fatty acids differs depending on their origin and nature. The beneficial properties of oils are attributed, in particular, to the amount of unsaturated fatty acids.
Ozonul reacţionează cu duble legături carbon-carbon ale acizilor graşi nesaturaţi şi este utilizat pentru a scinda alchena sau a introduce funcţionalităţi suplimentare de-a lungul lanţului (Scrimgeour C. Chemistry of Fatty Acids. In: Bailey's Industrial Oil and Fat Products. 6 ed., vol 1, John Wiley & Sons, Inc., 2005). Ozone reacts with carbon-carbon double bonds of unsaturated fatty acids and is used to cleave the alkene or introduce additional functionalities along the chain (Scrimgeour C. Chemistry of Fatty Acids. In: Bailey's Industrial Oil and Fat Products. 6 ed., vol 1, John Wiley & Sons, Inc., 2005).
În conformitate cu mecanismul de ozonoliză descris de Criegee în 1975 (Criegee R. Angew. Chem., Int. Ed., 1975, 14, p. 745), tratarea uleiului vegetal cu ozon furnizează compuşi ciclici numiţi ozonide (The Story of Ozone by Dr. Saul Pressman, DCh, LTOH, 1994) sau 1,2,4 trioxolani şi peroxizi (peroxizi polimerici şi alţi peroxizi) (Tellez G. M., Lozano L. O., Gomes M. F. D. Ozone Sci. Eng., 2006, p. 28, 181), considerate cele mai importante produse responsabile pentru activitatea antimicrobiană şi stimularea proprietăţilor de reparare şi regenerare a ţesuturilor (Bailey P. S. Ozonation in Organic Chemistry. Volume 1, Olefinic Compounds, New York, Academic Press, 1978), de asemenea sunt formaţi compuşi intermediari (zwitterioni, malozonide), care pot fi hidrolizate, oxidate, reduse şi descompuse termic în multe substanţe, în mare parte aldehide, cetone, acizi. According to the ozonolysis mechanism described by Criegee in 1975 (Criegee R. Angew. Chem., Int. Ed., 1975, 14, p. 745), the treatment of vegetable oil with ozone provides cyclic compounds called ozonides (The Story of Ozone by Dr. Saul Pressman, DCh, LTOH, 1994) or 1,2,4 trioxolanes and peroxides (polymeric peroxides and other peroxides) (Tellez G. M., Lozano L. O., Gomes M. F. D. Ozone Sci. Eng., 2006, p. 28, 181), considered the most important products responsible for antimicrobial activity and stimulation of tissue repair and regeneration properties (Bailey P. S. Ozonation in Organic Chemistry. Volume 1, Olefinic Compounds, New York, Academic Press, 1978), intermediate compounds (zwitterions, malozonides), which can be hydrolyzed, oxidized, reduced and thermally decomposed into many substances, mostly aldehydes, ketones, acids.
Ozonidele au o structură de tip inel, şi rezultă din ruperea, în urma reacţiei cu ozonul, a legăturilor duble de carbon aflate în acidul linolenic, acidul linoleic şi acidul oleic, componente naturale ale extractelor de plante. Ozonides have a ring-type structure, and result from the breaking, following the reaction with ozone, of the double carbon bonds found in linolenic acid, linoleic acid and oleic acid, natural components of plant extracts.
Acţiunea germicidă a ozonului a fost demonstrată pe un grup extins de microorganisme, inclusiv bacterii gram-pozitive şi gram-negative, precum şi pe fungi (Guzel-Seydim Z. B., Greene A. K., Seydim A. C. Food Science and Technology, 2004, 37, p. 453). The germicidal action of ozone has been demonstrated on a wide range of microorganisms, including gram-positive and gram-negative bacteria, as well as fungi (Guzel-Seydim Z. B., Greene A. K., Seydim A. C. Food Science and Technology, 2004, 37, p. 453).
Proprietăţile bactericide, fungicide şi virucide ale ozonului sunt atribuite capacităţii sale oxidative de a distruge multe dintre structurile enzimatice. Fireşte, fiecare microorganism are sensibilitate specifică la ozon. Bacteriile sunt mai sensibile comparativ cu celulele de drojdii şi fungi. Ca urmare a diferenţelor de structură a pereţilor celulari, bacteriile gram-pozitive sunt mult mai sensibile la ozon decât cele gram-negative (Skalska K., Ledakwicz S., Perkowski J., Sencio B. Ozone: Science & Engineering, 2009, 31, p. 232). The bactericidal, fungicidal and virucidal properties of ozone are attributed to its oxidative capacity to destroy many of the enzymatic structures. Naturally, each microorganism has a specific sensitivity to ozone. Bacteria are more sensitive compared to yeast and fungal cells. Due to differences in the structure of their cell walls, gram-positive bacteria are much more sensitive to ozone than gram-negative ones (Skalska K., Ledakwicz S., Perkowski J., Sencio B. Ozone: Science & Engineering, 2009, 31, p. 232).
O altă capacitate a ozonului este de a activa reacţiile dependente de oxigen a metabolismului şi a ciclului Krebs, cu formarea unei cantităţi mari de protoni necesare pentru restabilirea potenţialului antioxidant de apărare împotriva radicalilor liberi şi peroxidării lipidelor, astfel menţinând un echilibru dinamic între oxidare şi anti-oxidare (stresul oxidativ) responsabil pentru structura membranei şi metabolism (Ozonated Liquids in Dental Practice. Lime Technologies Holdings Ltd, April 2006). Another ability of ozone is to activate oxygen-dependent reactions of metabolism and the Krebs cycle, with the formation of a large amount of protons necessary to restore the antioxidant potential of defense against free radicals and lipid peroxidation, thus maintaining a dynamic balance between oxidation and anti-oxidation (oxidative stress) responsible for membrane structure and metabolism (Ozonated Liquids in Dental Practice. Lime Technologies Holdings Ltd, April 2006).
Probabil, atunci când ozonida stabilă vine în contact cu exsudatul din leziune, ea se descompune încet în diferiţi peroxizi, fapt ce poate explica activitatea prelungită antimicrobiană şi de stimulare a refacerii ţesutului (Travagli V., Zanardi I., Valacchi G., Bocci V. Mediators of Inflammation, 2010, Article ID 610418). Probably, when the stable ozonide comes into contact with the exudate from the lesion, it slowly decomposes into various peroxides, which may explain the prolonged antimicrobial and tissue repair-stimulating activity (Travagli V., Zanardi I., Valacchi G., Bocci V. Mediators of Inflammation, 2010, Article ID 610418).
S-a constatat că după un timp uleiul prin care barbota ozonul se transforma într-un gel semitransparent de consistenţa vaselinei, care reţinea ozonul pentru o perioadă mai lungă de timp şi avea proprietăţi antiseptice extrem de eficiente, fiind cu succes folosit în combaterea infecţiilor şi vindecarea rănilor. It was found that after a while the oil through which the ozone bubbled turned into a semi-transparent gel with the consistency of Vaseline, which retained the ozone for a longer period of time and had extremely effective antiseptic properties, being successfully used in combating infections and healing wounds.
Uleiul de olive este cel mai frecvent folosit la fabricarea ozonidelor şi implicit a cremei ozonate, cu toate acestea, există şi alte uleiuri vegetale care conţin uleiuri omega. Fiecare ulei are o concentraţie diferită de acizi graşi omega 3, 6, 9 şi concentraţia fiecărui acid gras este calculată aparte, suma lor formând un număr final care se numeşte "Indicele Potenţial de Ozonide " (POI) (Ozonated Liquids in Dental Practice, Lime Technologies Holdings Ltd, April 2006). Olive oil is the most commonly used oil in the manufacture of ozonides and thus ozonated cream, however, there are other vegetable oils that contain omega oils. Each oil has a different concentration of omega 3, 6, 9 fatty acids and the concentration of each fatty acid is calculated separately, their sum forming a final number called the "Potential Ozonide Index" (POI) (Ozonated Liquids in Dental Practice, Lime Technologies Holdings Ltd, April 2006).
Formula: Formula:
POI = 3s Omega (x3) + 6s Omega (x2) + 9s Omega (x1) POI = 3s Omega (x3) + 6s Omega (x2) + 9s Omega (x1)
Uleiurile cu un procent mai mare de acizi graşi reţin mai mult ozon, astfel se pot obţine creme cu diferite concentraţii de ozonide, de exemplu uleiul de in, având POI = 221, reţine cel mai mult ozon, iar uleiul de olive, având POI = 92, reţine un nivel mediu de ozon, astfel cremele ozonate pot fi clasificate după puterea de acţiune a ozonidelor în "înalte", "medii" şi "joase". Oils with a higher percentage of fatty acids retain more ozone, thus creams with different concentrations of ozonides can be obtained, for example, linseed oil, having POI = 221, retains the most ozone, and olive oil, having POI = 92, retains an average level of ozone, thus ozonated creams can be classified according to the strength of action of the ozonides into "high", "medium" and "low".
În alegerea uleiului un rol important îl joacă şi capacitatea de absorbţie a uleiului, şi modul în care interacţionează cu un anumit tip de piele sau mucoasă. De exemplu, uleiul ozonat de in se absoarbe greu, iar uleiul ozonat de olive foarte uşor. When choosing an oil, the oil's absorption capacity and how it interacts with a certain type of skin or mucous membrane also play an important role. For example, ozonated flax oil is absorbed slowly, while ozonated olive oil is absorbed very easily.
Pentru producerea uleiului ozonat semisolid utilizat în afecţiunile inflamatorii de natură bacteriană, virală şi micotică din cavitatea bucală, a fost aleasă o combinaţie dintre uleiul din seminţe de in (în proporţie de 30…60%) şi uleiul din seminţe de cânepă (în proporţie de 40…70%). Substanţele active care se obţin sunt ozonide şi peroxizi. For the production of the semi-solid ozonated oil used in inflammatory diseases of bacterial, viral and fungal nature in the oral cavity, a combination of linseed oil (in a proportion of 30…60%) and hemp seed oil (in a proportion of 40…70%) was chosen. The active substances obtained are ozonides and peroxides.
Echipamente şi materiale: Equipment and materials:
- Generator medical de ozon Ozon UM - 80 (producţia maximă de ozon - 2,4 g O3/oră) - Medical ozone generator Ozon UM - 80 (maximum ozone production - 2.4 g O3/hour)
- Butelie de oxigen medical cu reductor presiune - Medical oxygen cylinder with pressure reducer
- Ulei organic presat la rece - Cold-pressed organic oil
- Vas spălător de gaze tip Dreshle - 100 mL - Dreshle type gas scrubber - 100 mL
- Vas pentru răcire - 1000 mL - Cooling vessel - 1000 mL
- Tuburi de conexiune din materiale rezistente la ozon (silicon/teflon). - Connection tubes made of ozone-resistant materials (silicone/teflon).
Procedura de preparare a uleiului ozonat semisolid: Procedure for preparing semi-solid ozonated oil:
1. În vasul spălător de gaze tip Dreshle se iau 20 mL de amestec de uleiuri. 1. In the Dreshle gas scrubber, take 20 mL of oil mixture.
2. Vasul pentru răcire se umple cu 500 mL apă rece şi în el se introduce vasul spălător gaze tip Dreshle, pentru a evita supraîncălzirea uleiului în timpul barbotării. 2. Fill the cooling vessel with 500 mL of cold water and insert the Dreshle gas scrubber into it to avoid overheating the oil during bubbling.
3. Se conectează butelia de oxigen medical la generatorul de ozon medical prin tuburi de teflon şi se reglează presiunea la 2 bari. 3. Connect the medical oxygen cylinder to the medical ozone generator through Teflon tubes and adjust the pressure to 2 bars.
4. Se conectează vasul spălător de gaze tip Dreshle la generatorul de ozon medical prin tuburi de teflon. 4. Connect the Dreshle gas scrubber to the medical ozone generator via Teflon tubing.
5. Se conectează generatorul de ozon şi se barbotează uleiul cu 2,4 g O3 /oră, timp de 12…24 ore fără pauză, timp necesar pentru transformarea completă a uleiului într-o spumă expandată, care după stabilizare devine o cremă gelatinoasă semitransparentă, mată, de culoare albă. 5. Connect the ozone generator and bubble the oil with 2.4 g O3/hour, for 12…24 hours without a break, the time required for the complete transformation of the oil into an expanded foam, which after stabilization becomes a semi-transparent, matte, white gelatinous cream.
6. Se opreşte barbotarea, se toarnă uleiul ozonat semisolid într-o seringă de silicon rezistentă la ozon şi se plasează în frigider pentru păstrare. 6. Stop bubbling, pour the semi-solid ozonated oil into an ozone-resistant silicone syringe and place in the refrigerator for storage.
7. Păstrarea la temperatura camerei (nu este recomandată) va reduce eficienţa uleiului semisolid ozonat la 3…4 săptămâni, păstrarea în frigider (0…4°C) va menţine eficienţa uleiului ozonat semisolid pentru o perioadă lungă de timp (6 luni), păstrarea în congelator este ideală pentru stocarea uleiului ozonat semisolid pe termen lung (ani). 7. Storing at room temperature (not recommended) will reduce the effectiveness of ozonated semi-solid oil to 3…4 weeks, storing in the refrigerator (0…4°C) will maintain the effectiveness of ozonated semi-solid oil for a long period of time (6 months), storing in the freezer is ideal for long-term storage of ozonated semi-solid oil (years).
După stabilirea diagnosticului în baza datelor clinice, paraclinice şi funcţionale se efectuează spălarea şi planarea radiculară (SRP) a dinţilor, apoi pacientului i se aplică pe arcadele dentare gutierele prefabricate în care iniţial a fost plasat uleiul ozonat semisolid, care include ulei din seminţe de in 30…60% şi ulei din seminţe de cânepă 40…70%, ce conţine 40000 µg/L de ozon. Gutierele se poartă timp de o oră, după care se scot şi cavitatea bucală este clătită cu apă sau cu o seringă se introduce în punga parodontală amestecul medicamentos o dată pe zi, timp de 5…8 zile. After establishing the diagnosis based on clinical, paraclinical and functional data, teeth are washed and root planed (SRP), then the patient is fitted with prefabricated trays on the dental arches, in which the semi-solid ozonated oil was initially placed, which includes 30…60% flaxseed oil and 40…70% hempseed oil, which contains 40,000 µg/L of ozone. The trays are worn for one hour, after which they are removed and the oral cavity is rinsed with water or the medicinal mixture is introduced into the periodontal pocket with a syringe once a day for 5…8 days.
Exemplul 1 Example 1
Pacienta B., în vârstă de 56 ani, s-a adresat cu acuze la dureri difuze ale gingiilor, sângerare spontană şi la periaj, halenă fetidă, tulburări de masticaţie prin instabilitate dentară, abcese parodontale frecvente. La examinare se evidenţiază recesiune gingivală generalizată, mai pronunţată pe grupul lateral de dinţi, pungi parodontale mai adânci de 6 mm, cu exsudat purulent, sângerare la palpare, mobilitate dentară gr. II…III, tartru şi placă bacteriană abundentă. Patient B., 56 years old, complained of diffuse gum pain, spontaneous bleeding and bleeding during brushing, bad breath, chewing disorders due to dental instability, frequent periodontal abscesses. Examination revealed generalized gingival recession, more pronounced on the lateral group of teeth, periodontal pockets deeper than 6 mm, with purulent exudate, bleeding on palpation, tooth mobility grade II…III, abundant tartar and bacterial plaque.
Diagnosticul: Parodontită marginală cronică generalizată severă. Diagnosis: Severe generalized chronic marginal periodontitis.
Aplicarea uleiului ozonat semisolid s-a făcut zilnic timp de 5 zile. După prima şedinţă la pacientă s-a redus esenţial inflamaţia. După cea de-a doua a dispărut sângerarea şi exsudatul purulent. La sfârşitul tratamentului pungile gingivale s-au redus cu 2…3 mm, gingia avea aspect şi consistenţă normală, fără exsudat purulent sau sângerare. Mobilitate dentară redusă semnificativ. The application of the semi-solid ozonated oil was done daily for 5 days. After the first session, the patient's inflammation was essentially reduced. After the second, the bleeding and purulent exudate disappeared. At the end of the treatment, the gingival pockets were reduced by 2…3 mm, the gum had a normal appearance and consistency, without purulent exudate or bleeding. Tooth mobility was significantly reduced.
Exemplul 2 Example 2
Pacientul C., în vârstă de 39 ani, s-a adresat cu următoarele acuze: dureri şi sângerare a gingiilor la periaj şi în timpul alimentaţiei, halenă fetidă. La examinare s-a evidenţiat hiperemia gingiei cu hipertrofia papilelor interdentale, sângerare la palpare, pungi false, placă bacteriană şi tartru abundent, mobilitate dentară gr. I. Patient C., 39 years old, presented with the following complaints: pain and bleeding of the gums when brushing and eating, foul breath. Examination revealed gingival hyperemia with hypertrophy of the interdental papillae, bleeding on palpation, false pockets, abundant bacterial plaque and tartar, tooth mobility gr. I.
Diagnosticul: Parodontită marginală cronică generalizată moderată. Diagnosis: Moderate generalized chronic marginal periodontitis.
A fost introdus cu ajutorul unei seringi amestecul medicamentos, câte 0,2 mL în fiecare pungă parodontală o dată pe zi, timp de 5 zile. După prima şedinţă s-a redus semnificativ inflamaţia şi durerea, după a treia şedinţă s-a observat schimbarea evidentă a culorii gingiei, dispariţia sângerării la palpare şi reducerea volumului papilelor. După efectuarea tratamentului au dispărut complet toate acuzele. The medicinal mixture was introduced with a syringe, 0.2 mL into each periodontal pocket once a day, for 5 days. After the first session, inflammation and pain were significantly reduced, after the third session, a clear change in the color of the gums, the disappearance of bleeding on palpation and a reduction in the volume of the papillae were observed. After the treatment, all complaints disappeared completely.
1. Shoukheba M., Ali Sh. A. The effects of subgingival application of ozonated olive oil gel in patient with localized aggressive periodontitis. A clinical and bacteriological study. Tanta Dental Journal, April 2014, vol. 11, p. 63-73 1. Shoukheba M., Ali Sh. A. The effects of subgingival application of ozonated olive oil gel in patients with localized aggressive periodontitis. A clinical and bacteriological study. Tanta Dental Journal, April 2014, vol. 11, p. 63-73
2. RU 2123319 C1 1998.12.20 2. RU 2123319 C1 1998.12.20
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| Shoukheba M., Ali Sh. A. The effects of subgingival application of ozonated olive oil gel in patient with localized aggressive periodontitis. A clinical and bacteriological study. Tanta Dental Journal, April 2014, vol. 11, p. 63-73 * |
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