MA57504B1 - Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl hydrogen sulfate )-3-hydroxypyrrolidine-1-carboxamide - Google Patents

Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl hydrogen sulfate )-3-hydroxypyrrolidine-1-carboxamide

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Publication number
MA57504B1
MA57504B1 MA57504A MA57504A MA57504B1 MA 57504 B1 MA57504 B1 MA 57504B1 MA 57504 A MA57504 A MA 57504A MA 57504 A MA57504 A MA 57504A MA 57504 B1 MA57504 B1 MA 57504B1
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MA
Morocco
Prior art keywords
hydroxypyrrolidine
pyrazolo
difluorophenyl
pyrrolidin
pyrimidin
Prior art date
Application number
MA57504A
Other languages
French (fr)
Inventor
Alisha B Arrigo
Derrick Juengst
Khalid Shah
Original Assignee
Array Biopharma Inc
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Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of MA57504B1 publication Critical patent/MA57504B1/en

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Abstract

Une nouvelle forme cristalline de (s)-n-(5-((r)-2-(2,5-difluorophényl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)- l'invention concerne le 3-hydroxypyrrolidine-1-carboxamide, des compositions pharmaceutiques contenant ladite forme cristalline et l'utilisation de ladite forme cristalline dans le traitement de la douleur, du cancer, de l'inflammation, d'une maladie neurodégénérative ou d'une infection à trypanosoma cruzi. Dans certains modes de réalisation, la nouvelle forme cristalline comprend un polymorphe stable de (s)-n-(5-((r)-2-(2,5-difluorophényl)pyrrolidin-1-yl)-pyrazolo[1,5-a hydrogénosulfate de ]pyrimidine-3-yl)-3-hydroxypyrrolidine-1-carboxamide.A new crystal form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)- the invention relates to 3-hydroxypyrrolidine-1-carboxamide, pharmaceutical compositions containing said crystalline form and the use of said crystalline form in the treatment of pain, cancer, inflammation, neurodegenerative disease or a trypanosoma cruzi infection. In some embodiments, the novel crystal form comprises a stable polymorph of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5 [a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate.

MA57504A 2014-11-16 2015-11-16 Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl hydrogen sulfate )-3-hydroxypyrrolidine-1-carboxamide MA57504B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462080374P 2014-11-16 2014-11-16

Publications (1)

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MA57504B1 true MA57504B1 (en) 2023-03-31

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Family Applications (1)

Application Number Title Priority Date Filing Date
MA57504A MA57504B1 (en) 2014-11-16 2015-11-16 Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl hydrogen sulfate )-3-hydroxypyrrolidine-1-carboxamide

Country Status (1)

Country Link
MA (1) MA57504B1 (en)

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