MA56430B1 - Benzothiadiazepine compounds and their use as bile acid modulators - Google Patents

Benzothiadiazepine compounds and their use as bile acid modulators

Info

Publication number
MA56430B1
MA56430B1 MA56430A MA56430A MA56430B1 MA 56430 B1 MA56430 B1 MA 56430B1 MA 56430 A MA56430 A MA 56430A MA 56430 A MA56430 A MA 56430A MA 56430 B1 MA56430 B1 MA 56430B1
Authority
MA
Morocco
Prior art keywords
bile acid
compounds
acid modulators
benzothiadiazepine
relates
Prior art date
Application number
MA56430A
Other languages
French (fr)
Other versions
MA56430A (en
Inventor
Santosh S Kulkarni
Per-Göran Gillberg
Jan Mattsson
Ingemar Starke
Original Assignee
Albireo Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albireo Ab filed Critical Albireo Ab
Priority claimed from PCT/EP2020/052942 external-priority patent/WO2020161217A1/en
Publication of MA56430A publication Critical patent/MA56430A/en
Publication of MA56430B1 publication Critical patent/MA56430B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/36—Seven-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

L'invention concerne des dérivés de 1, 2, 5-benzothiadiazépine de formule (i). Ces composés sont des modulateurs d'acide biliaire ayant une activité inhibitrice de transporteur d'acide biliaire dépendant du sodium apical (asbt) et/ou de transport d'acide biliaire hépatique (lbat). L'invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés dans le traitement de maladies cardiovasculaires, de troubles du métabolisme des acides gras et du glucose, de maladies gastro-intestinales et de maladies hépatiques.The invention relates to 1,2,5-benzothiadiazepine derivatives of formula (i). These compounds are bile acid modulators having inhibitory activity of apical sodium-dependent bile acid transporter (asbt) and/or hepatic bile acid transport (lbat). The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds in the treatment of cardiovascular diseases, disorders of fatty acid and glucose metabolism, gastrointestinal diseases and liver diseases.

MA56430A 2019-02-06 2020-02-06 Benzothiadiazepine compounds and their use as bile acid modulators MA56430B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201911004690 2019-02-06
PCT/EP2020/052942 WO2020161217A1 (en) 2019-02-06 2020-02-06 Benzothiadiazepine compounds and their use as bile acid modulators

Publications (2)

Publication Number Publication Date
MA56430A MA56430A (en) 2022-05-11
MA56430B1 true MA56430B1 (en) 2023-01-31

Family

ID=78076066

Family Applications (1)

Application Number Title Priority Date Filing Date
MA56430A MA56430B1 (en) 2019-02-06 2020-02-06 Benzothiadiazepine compounds and their use as bile acid modulators

Country Status (2)

Country Link
AR (2) AR118026A1 (en)
MA (1) MA56430B1 (en)

Also Published As

Publication number Publication date
AR118026A1 (en) 2021-09-15
AR118025A1 (en) 2021-09-15
MA56430A (en) 2022-05-11

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