MA46064A - PYRIDIN-2- (1H) -ONE-QUINOLINONE DERIVATIVES AS ISOCITRATE DEHYDROGENASE INHIBITORS - Google Patents

PYRIDIN-2- (1H) -ONE-QUINOLINONE DERIVATIVES AS ISOCITRATE DEHYDROGENASE INHIBITORS

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Publication number
MA46064A
MA46064A MA046064A MA46064A MA46064A MA 46064 A MA46064 A MA 46064A MA 046064 A MA046064 A MA 046064A MA 46064 A MA46064 A MA 46064A MA 46064 A MA46064 A MA 46064A
Authority
MA
Morocco
Prior art keywords
pyridin
isocitrate dehydrogenase
dehydrogenase inhibitors
quinolinone derivatives
quinolinone
Prior art date
Application number
MA046064A
Other languages
French (fr)
Other versions
MA46064B1 (en
Inventor
Susan Ashwell
Ann-Marie Campbell
Justin Andrew Caravella
R Bruce Diebold
Anna Ericsson
Gary Gustafson
David R Lancia Jr
Jian Lin
Wei Lu
Zhongguo Wang
Original Assignee
Forma Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forma Therapeutics Inc filed Critical Forma Therapeutics Inc
Publication of MA46064A publication Critical patent/MA46064A/en
Publication of MA46064B1 publication Critical patent/MA46064B1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Cette invention concerne des inhibiteurs de protéines d'isocitrate déshydrogénase mutantes (mt-idh) ayant une activité néomorphe, utiles pour traiter les troubles liés à la prolifération cellulaire et les cancers, de formule : (i) où a, u, w1, w2, w3, r1-r6, et r9 sont tels que décrits dans la présente.This invention relates to mutant isocitrate dehydrogenase (mt-idh) protein inhibitors having neomorphic activity useful for treating cell proliferation-related disorders and cancers of the formula: (i) where a, u, w1, w2 , w3, r1-r6, and r9 are as described herein.

MA46064A 2014-09-19 2015-09-18 Pyridin-2- (1h) -one-quinolinone derivatives as isocitrate dehydrogenase inhibitors MA46064B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462053006P 2014-09-19 2014-09-19
US201562128089P 2015-03-04 2015-03-04
US201562150812P 2015-04-21 2015-04-21

Publications (2)

Publication Number Publication Date
MA46064A true MA46064A (en) 2019-07-03
MA46064B1 MA46064B1 (en) 2020-04-30

Family

ID=58698665

Family Applications (1)

Application Number Title Priority Date Filing Date
MA46064A MA46064B1 (en) 2014-09-19 2015-09-18 Pyridin-2- (1h) -one-quinolinone derivatives as isocitrate dehydrogenase inhibitors

Country Status (3)

Country Link
AR (1) AR101976A1 (en)
HR (1) HRP20182176T1 (en)
MA (1) MA46064B1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107556366A (en) * 2016-06-30 2018-01-09 上海海和药物研究开发有限公司 Compound, preparation method and the usage with saltant type isocitric dehydrogenase inhibitory activity
MX2023013664A (en) * 2021-06-15 2024-01-08 Wigen Biomedicine Tech Shanghai Co Ltd Idh mutant inhibitor and use thereof.

Also Published As

Publication number Publication date
HRP20182176T1 (en) 2019-02-22
MA46064B1 (en) 2020-04-30
AR101976A1 (en) 2017-01-25

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MA46064A (en) PYRIDIN-2- (1H) -ONE-QUINOLINONE DERIVATIVES AS ISOCITRATE DEHYDROGENASE INHIBITORS