MA43507B1 - Mono or di-substituted indole derivatives as dengue virus replication inhibitors - Google Patents

Mono or di-substituted indole derivatives as dengue virus replication inhibitors

Info

Publication number
MA43507B1
MA43507B1 MA43507A MA43507A MA43507B1 MA 43507 B1 MA43507 B1 MA 43507B1 MA 43507 A MA43507 A MA 43507A MA 43507 A MA43507 A MA 43507A MA 43507 B1 MA43507 B1 MA 43507B1
Authority
MA
Morocco
Prior art keywords
dengue virus
compounds
mono
virus replication
indole derivatives
Prior art date
Application number
MA43507A
Other languages
French (fr)
Inventor
Tim Jonckers
Pierre Raboisson
Bart Kesteleyn
Jean-François Bonfanti
Dorothée Bardiot
Arnaud Marchand
Original Assignee
Janssen Pharmaceuticals Inc
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc, Univ Leuven Kath filed Critical Janssen Pharmaceuticals Inc
Priority claimed from PCT/EP2016/059975 external-priority patent/WO2016180696A1/en
Publication of MA43507B1 publication Critical patent/MA43507B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des composés indole monosubstitués ou disubstitués, des méthodes pour prévenir ou traiter les infections provoquées par le virus de la dengue à l'aide de tels composés. La présente invention concerne également lesdits composés qui sont destinés à être utilisés en tant que médicaments, de préférence destinés à être utilisés en tant que médicaments pour traiter ou prévenir les infections provoquées par le virus de la dengue. La présente invention concerne en outre des compositions pharmaceutiques ou des préparations combinées de ces composés, des compositions ou des préparations qui sont utilisées en tant que médicaments, de préférence pour la prévention ou le traitement d'infections provoquées par le virus de la dengue. L'invention concerne également des procédés de préparation de ces composés.The present invention relates to monosubstituted or disubstituted indole compounds, methods for preventing or treating infections caused by dengue virus using such compounds. The present invention also relates to said compounds which are intended for use as medicaments, preferably for use as medicaments for treating or preventing infections caused by the dengue virus. The present invention further relates to pharmaceutical compositions or combined preparations of these compounds, compositions or preparations which are used as medicaments, preferably for the prevention or treatment of infections caused by the dengue virus. The invention also relates to methods of preparing these compounds.

MA43507A 2015-05-08 2016-05-04 Mono or di-substituted indole derivatives as dengue virus replication inhibitors MA43507B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15166900 2015-05-08
PCT/EP2016/059975 WO2016180696A1 (en) 2015-05-08 2016-05-04 Mono- or di-substituted indole derivatives as dengue viral replication inhibitors

Publications (1)

Publication Number Publication Date
MA43507B1 true MA43507B1 (en) 2021-08-31

Family

ID=53059008

Family Applications (1)

Application Number Title Priority Date Filing Date
MA43507A MA43507B1 (en) 2015-05-08 2016-05-04 Mono or di-substituted indole derivatives as dengue virus replication inhibitors

Country Status (3)

Country Link
AR (2) AR104504A1 (en)
MA (1) MA43507B1 (en)
MY (1) MY185672A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114989131B (en) * 2022-05-30 2023-10-24 云南大学 N' - (2- (benzo [1,3] dioxolan-5-yl) acyl) aryl hydrazide compound as well as synthesis and application thereof

Also Published As

Publication number Publication date
AR120158A2 (en) 2022-02-02
AR104504A1 (en) 2017-07-26
MY185672A (en) 2021-05-29

Similar Documents

Publication Publication Date Title
MA40768A (en) MONO OR DI-SUBSTITUTE INDOLE DERIVATIVES AS DENGUE VIRUS REPLICATION INHIBITORS
MA42811B1 (en) Monosubstituted or disubstituted indole derivatives used as inhibitors of dengue virus replication
MA40769B1 (en) Mono- or di-substituted isolates used as replication inhibitors of dengue virus
MA40111A1 (en) Derivatives of tetrahydronaphthalene inhibiting mcl-1 protein
MA53399B1 (en) Substituted pyrazoles as inhibitors of human plasma kallikrein
PH12018502026A1 (en) Substituted indole compound derivatives as dengue viral replication inhibitors
MA45153B1 (en) Substituted carbonucleoside derivatives useful as anticancer agents
PH12019502577A1 (en) Substituted indoline derivatives as dengue viral replication inhibitors
PH12019502201A1 (en) Substituted indoline derivatives as dengue viral replication inhibitors
PH12018502077A1 (en) Substituted indoline derivatives as dengue viral replication inhibitors
PH12018502015A1 (en) Substituted indole derivatives as dengue viral replication inhibitors
MA42230B1 (en) Bicyclic derivatives, process for their preparation, and pharmaceutical compositions containing them
PH12019502095A1 (en) Substituted indoline derivatives as dengue viral replication inhibitors
PH12018502016A1 (en) Substituted indole derivatives as dengue viral replication inhibitors
PH12019502559A1 (en) Substituted indoline derivatives as dengue viral replication inhibitors
MX2022000453A (en) Compounds useful to treat influenza virus infections.
MA45782B1 (en) Modulators of the cxcr7 piperidine receptor
MA43913B1 (en) Positive allosteric modulators of the m1 muscarinic receptor
MA43052B1 (en) Human Plasma Kallikrein Inhibitors
MA42769B1 (en) Fluoroindole derivatives as positive allosteric modulators of the m1 muscarinic receptor
MA41174B1 (en) Imidazopyridazine derivatives used as pi3kbeta inhibitors
MA39253A1 (en) Substituted bicyclic heteroaryl compounds used as rxr agonists
MA43507B1 (en) Mono or di-substituted indole derivatives as dengue virus replication inhibitors
MA49994A1 (en) Macrocyclic compounds for the treatment of disease
FR3042191B1 (en) 1,4,8-TRIAZAPHENANTHRENE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES