MA43507B1 - Mono or di-substituted indole derivatives as dengue virus replication inhibitors - Google Patents

Mono or di-substituted indole derivatives as dengue virus replication inhibitors

Info

Publication number
MA43507B1
MA43507B1 MA43507A MA43507A MA43507B1 MA 43507 B1 MA43507 B1 MA 43507B1 MA 43507 A MA43507 A MA 43507A MA 43507 A MA43507 A MA 43507A MA 43507 B1 MA43507 B1 MA 43507B1
Authority
MA
Morocco
Prior art keywords
dengue virus
compounds
mono
virus replication
indole derivatives
Prior art date
Application number
MA43507A
Other languages
French (fr)
Inventor
Tim Jonckers
Pierre Raboisson
Bart Kesteleyn
Jean-François Bonfanti
Dorothée Bardiot
Arnaud Marchand
Original Assignee
Janssen Pharmaceuticals Inc
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc, Univ Leuven Kath filed Critical Janssen Pharmaceuticals Inc
Priority claimed from PCT/EP2016/059975 external-priority patent/WO2016180696A1/en
Publication of MA43507B1 publication Critical patent/MA43507B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des composés indole monosubstitués ou disubstitués, des méthodes pour prévenir ou traiter les infections provoquées par le virus de la dengue à l'aide de tels composés. La présente invention concerne également lesdits composés qui sont destinés à être utilisés en tant que médicaments, de préférence destinés à être utilisés en tant que médicaments pour traiter ou prévenir les infections provoquées par le virus de la dengue. La présente invention concerne en outre des compositions pharmaceutiques ou des préparations combinées de ces composés, des compositions ou des préparations qui sont utilisées en tant que médicaments, de préférence pour la prévention ou le traitement d'infections provoquées par le virus de la dengue. L'invention concerne également des procédés de préparation de ces composés.The present invention relates to monosubstituted or disubstituted indole compounds, methods for preventing or treating infections caused by dengue virus using such compounds. The present invention also relates to said compounds which are intended for use as medicaments, preferably for use as medicaments for treating or preventing infections caused by the dengue virus. The present invention further relates to pharmaceutical compositions or combined preparations of these compounds, compositions or preparations which are used as medicaments, preferably for the prevention or treatment of infections caused by the dengue virus. The invention also relates to methods of preparing these compounds.

MA43507A 2015-05-08 2016-05-04 Mono or di-substituted indole derivatives as dengue virus replication inhibitors MA43507B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15166900 2015-05-08
PCT/EP2016/059975 WO2016180696A1 (en) 2015-05-08 2016-05-04 Mono- or di-substituted indole derivatives as dengue viral replication inhibitors

Publications (1)

Publication Number Publication Date
MA43507B1 true MA43507B1 (en) 2021-08-31

Family

ID=53059008

Family Applications (1)

Application Number Title Priority Date Filing Date
MA43507A MA43507B1 (en) 2015-05-08 2016-05-04 Mono or di-substituted indole derivatives as dengue virus replication inhibitors

Country Status (3)

Country Link
AR (2) AR104504A1 (en)
MA (1) MA43507B1 (en)
MY (1) MY185672A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114989131B (en) * 2022-05-30 2023-10-24 云南大学 N' - (2- (benzo [1,3] dioxolan-5-yl) acyl) aryl hydrazide compound as well as synthesis and application thereof

Also Published As

Publication number Publication date
AR104504A1 (en) 2017-07-26
AR120158A2 (en) 2022-02-02
MY185672A (en) 2021-05-29

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