MA39719B1 - Pyrazoles substituted with trifluoromethyl as inhibitors of human plasma kallikrein - Google Patents

Pyrazoles substituted with trifluoromethyl as inhibitors of human plasma kallikrein

Info

Publication number
MA39719B1
MA39719B1 MA39719A MA39719A MA39719B1 MA 39719 B1 MA39719 B1 MA 39719B1 MA 39719 A MA39719 A MA 39719A MA 39719 A MA39719 A MA 39719A MA 39719 B1 MA39719 B1 MA 39719B1
Authority
MA
Morocco
Prior art keywords
plasma kallikrein
inhibitors
trifluoromethyl
human plasma
compounds
Prior art date
Application number
MA39719A
Other languages
French (fr)
Inventor
Minwan Wu
Weihe Zhang
Yarlagadda S Babu
Pravin L Kotian
Venkat R Chintareddy
Satish V Kumar
Original Assignee
Biocryst Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocryst Pharm Inc filed Critical Biocryst Pharm Inc
Priority claimed from PCT/US2015/019535 external-priority patent/WO2015134998A1/en
Publication of MA39719B1 publication Critical patent/MA39719B1/en

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Abstract

Cette invention concerne des composés de formule (i), et leurs sels de qualité pharmaceutique. Les composés sont des inhibiteurs de la kallicréine plasmatique l'invention concerne également des compositions pharmaceutiques comprenant au moins un composé de l'invention, et des procédés impliquant l'utilisation des composés et des compositions de l'invention dans le traitement et la prévention de maladies et de pathologies caractérisées par une activité indésirable de la kallicréine plasmatique.This invention relates to compounds of formula (i), and their pharmaceutical grade salts. The compounds are inhibitors of plasma kallikrein The invention also relates to pharmaceutical compositions comprising at least one compound of the invention, and to methods involving the use of the compounds and compositions of the invention in the treatment and prevention of diseases and pathologies characterized by undesirable activity of plasma kallikrein.

MA39719A 2014-03-07 2015-03-09 Pyrazoles substituted with trifluoromethyl as inhibitors of human plasma kallikrein MA39719B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461949808P 2014-03-07 2014-03-07
PCT/US2015/019535 WO2015134998A1 (en) 2014-03-07 2015-03-09 Human plasma kallikrein inhibitors

Publications (1)

Publication Number Publication Date
MA39719B1 true MA39719B1 (en) 2020-12-31

Family

ID=74126541

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39719A MA39719B1 (en) 2014-03-07 2015-03-09 Pyrazoles substituted with trifluoromethyl as inhibitors of human plasma kallikrein

Country Status (1)

Country Link
MA (1) MA39719B1 (en)

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