MA39227A1 - Heteroaryl amides as inhibitors of protein aggregation - Google Patents

Heteroaryl amides as inhibitors of protein aggregation

Info

Publication number
MA39227A1
MA39227A1 MA39227A MA39227A MA39227A1 MA 39227 A1 MA39227 A1 MA 39227A1 MA 39227 A MA39227 A MA 39227A MA 39227 A MA39227 A MA 39227A MA 39227 A1 MA39227 A1 MA 39227A1
Authority
MA
Morocco
Prior art keywords
disease
protein aggregation
methods
inhibitors
parkinson
Prior art date
Application number
MA39227A
Other languages
French (fr)
Other versions
MA39227B1 (en
Inventor
Emily M Stocking
Wolfgang Wrasidlo
Original Assignee
Neuropore Therapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuropore Therapies Inc filed Critical Neuropore Therapies Inc
Priority claimed from PCT/US2015/013263 external-priority patent/WO2015116663A1/en
Publication of MA39227A1 publication Critical patent/MA39227A1/en
Publication of MA39227B1 publication Critical patent/MA39227B1/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne certains composés d'amide hétéroaryles, des compositions pharmaceutiques les contenant et des procédés d'utilisation associés, notamment des procédés permettant de prévenir, inverser, ralentir et inhiber l'agrégation protéique, et des procédés permettant de traiter des maladies qui sont associées à l'agrégation protéique, notamment les maladies neurodégénératives telles que la maladie de parkinson, la maladie d'alzheimer, la maladie du corps de lewy, la maladie de parkinson avec démence, la démence fronto-temporale, la maladie de huntington, la sclérose latérale amyotrophique et l'atrophie multisystématisée, et le cancer et le mélanome.The present invention relates to certain heteroaryl amide compounds, pharmaceutical compositions containing them and methods of use thereof, including methods of preventing, reversing, slowing down and inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy's body disease, Parkinson's disease with dementia, Frontotemporal dementia, Huntington's disease, amyotrophic lateral sclerosis and multisystematous atrophy, and cancer and melanoma.

MA39227A 2014-01-29 2015-01-28 Heteroaryl amides as inhibitors of protein aggregation MA39227B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461933246P 2014-01-29 2014-01-29
PCT/US2015/013263 WO2015116663A1 (en) 2014-01-29 2015-01-28 Heteroarly amides as inhibitors of protein aggregation

Publications (2)

Publication Number Publication Date
MA39227A1 true MA39227A1 (en) 2017-09-29
MA39227B1 MA39227B1 (en) 2018-04-30

Family

ID=58698445

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39227A MA39227B1 (en) 2014-01-29 2015-01-28 Heteroaryl amides as inhibitors of protein aggregation

Country Status (2)

Country Link
AR (1) AR099208A1 (en)
MA (1) MA39227B1 (en)

Also Published As

Publication number Publication date
MA39227B1 (en) 2018-04-30
AR099208A1 (en) 2016-07-06

Similar Documents

Publication Publication Date Title
MA41013A (en) COMPOSITIONS CONTAINING BACTERIAL STRAINS
PH12016501493A1 (en) Heteroaryl amides as inhibitors of protein aggregation
MX2018005600A (en) Pharmaceutical compositions and methods for indoleamine 2,3-dioxygenase inhibition and indications therefor.
SA519400950B1 (en) Compositions and Methods of Inhibiting MASP-3 for The Treatment of Various Diseases and Disorders
MX2019007480A (en) Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation.
GEP20207151B (en) Agents, Uses and Methods for the Treatment of Synucleinopathy
MA40240A (en) HETERARYL KINASE INHIBITION COMPOUNDS
MX2019003805A (en) Activators of autophagic flux and phospholipase d and clearance of protein aggregates including tau and treatment of proteinopathies.
MX2019004859A (en) Combination treatments comprising administration of imidazopyrazinones.
PH12018500659A1 (en) Compounds effective in treating hepatotoxicity and fatty liver diseases and uses thereof
EA201991755A1 (en) Bicyclic bisheteroaryl derivatives as protein aggregation modulators
MX2019007053A (en) Bis-heteroaryl derivatives as modulators of protein aggregation.
MX2015000618A (en) Di-and tri-heteroaryl derivatives as inhibitors of protein aggregation.
MY184878A (en) Compositions and methods for treating neurodegenerative diseases
MX2019001634A (en) Amide compounds, pharmaceutical compositions thereof, and methods of using the same.
MX2018001592A (en) Compositions and methods for treating and preventing neurodegenerative disorders.
EA201991753A1 (en) Alcoxybisheteroaryl derivatives as protein aggregation modulators
MX2019008603A (en) A pharmaceutical composition comprising an oxazine derivative and its use in the treatment or prevention of alzheimer's disease.
MX2020006140A (en) Cyclobenzaprine treatment for agitation, psychosis and cognitive decline in dementia and neurodegenerative conditions.
EP3610879A4 (en) Composition for treatment and/or prevention of alzheimer's disease
MA39227A1 (en) Heteroaryl amides as inhibitors of protein aggregation
EP3773500A4 (en) Compositions and methods of detecting and treating alzheimer's disease