MA39173B1 - Tropomyosin-related kinase inhibitors (trk) - Google Patents

Tropomyosin-related kinase inhibitors (trk)

Info

Publication number
MA39173B1
MA39173B1 MA39173A MA39173A MA39173B1 MA 39173 B1 MA39173 B1 MA 39173B1 MA 39173 A MA39173 A MA 39173A MA 39173 A MA39173 A MA 39173A MA 39173 B1 MA39173 B1 MA 39173B1
Authority
MA
Morocco
Prior art keywords
tropomyosin
related kinase
trk
useful
treatment
Prior art date
Application number
MA39173A
Other languages
French (fr)
Other versions
MA39173A2 (en
MA39173A3 (en
Inventor
Markus Metz
Andrew Scholte
John L Kane
Gloria Matthews
Michael Kothe
Jinyu Liu
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Priority claimed from PCT/US2014/069469 external-priority patent/WO2015089139A1/en
Publication of MA39173A2 publication Critical patent/MA39173A2/en
Publication of MA39173A3 publication Critical patent/MA39173A3/en
Publication of MA39173B1 publication Critical patent/MA39173B1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des inhibiteurs de kinases apparentées à la tropomyosine (inhibiteurs de trk), qui sont des composés de type petites molécules, utiles dans le traitement de maladie. Les inhibiteurs de trk peuvent être utilisés comme agents pharmaceutiques et dans des compositions pharmaceutiques. Les inhibiteurs de trk sont utiles dans le traitement de maladies inflammatoires, d'une maladie auto-immune, de défaillances du métabolisme osseux et/ou du cancer, et sont particulièrement utiles dans le traitement de l'ostéoarthrite (oa), de la douleur et d'une douleur associée à l'oa. Les inhibiteurs de trk sont également utiles pour inhiber la kinase apparentée à la tropomyosine a (trka), la kinase apparentée à la tropomyosine b (trkb), la kinase apparentée à la tropomyosine c (trkc), et/ou le c-fms (le récepteur cellulaire du facteur-1 de stimulation des colonies (csf-1)).The invention provides inhibitors of tropomyosin-related kinases (trk inhibitors), which are small molecule compounds useful in the treatment of disease. The trk inhibitors can be used as pharmaceutical agents and in pharmaceutical compositions. Trk inhibitors are useful in the treatment of inflammatory diseases, autoimmune disease, failure of bone metabolism and / or cancer, and are particularly useful in the treatment of osteoarthritis (oa), pain and pain associated with oa. Trk inhibitors are also useful for inhibiting tropomyosin a-related kinase (trka), tropomyosin b-related kinase (trkb), tropomyosin c-related kinase (trkc), and / or c-fms ( colony stimulating factor-1 cell receptor (csf-1)).

MA39173A 2013-12-10 2014-12-10 Tropomyosin-related kinase inhibitors (trk) MA39173B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361914128P 2013-12-10 2013-12-10
PCT/US2014/069469 WO2015089139A1 (en) 2013-12-10 2014-12-10 Tropomyosin-related kinase (trk) inhibitors

Publications (3)

Publication Number Publication Date
MA39173A2 MA39173A2 (en) 2017-12-29
MA39173A3 MA39173A3 (en) 2018-05-31
MA39173B1 true MA39173B1 (en) 2020-05-29

Family

ID=58698472

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39173A MA39173B1 (en) 2013-12-10 2014-12-10 Tropomyosin-related kinase inhibitors (trk)

Country Status (2)

Country Link
AR (1) AR098695A1 (en)
MA (1) MA39173B1 (en)

Also Published As

Publication number Publication date
MA39173A2 (en) 2017-12-29
MA39173A3 (en) 2018-05-31
AR098695A1 (en) 2016-06-08

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