MA38812B1 - 1- (Chloromethyl) -2,3-dihydro-1H-benzo [e] indole antibody-drug conjugates, and methods of use and treatment - Google Patents

1- (Chloromethyl) -2,3-dihydro-1H-benzo [e] indole antibody-drug conjugates, and methods of use and treatment

Info

Publication number
MA38812B1
MA38812B1 MA38812A MA38812A MA38812B1 MA 38812 B1 MA38812 B1 MA 38812B1 MA 38812 A MA38812 A MA 38812A MA 38812 A MA38812 A MA 38812A MA 38812 B1 MA38812 B1 MA 38812B1
Authority
MA
Morocco
Prior art keywords
antibody
chloromethyl
indole
benzo
dihydro
Prior art date
Application number
MA38812A
Other languages
French (fr)
Other versions
MA38812A1 (en
Inventor
Binqing Wei
John A Flygare
Brian Safina
Thomas H Pillow
Visha Verma
William Denny
Anna Giddens
Ho Lee
Guo-Liang Lu
Christian Miller
Gordon REWCASTLE
Moana Tercel
Muriel Bonnet
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Priority claimed from PCT/US2014/042560 external-priority patent/WO2015023355A1/en
Publication of MA38812A1 publication Critical patent/MA38812A1/en
Publication of MA38812B1 publication Critical patent/MA38812B1/en

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des conjugués anticorps-médicament comprenant un anticorps conjugué avec une fraction médicament dimérique 1-(chlorométhyl)-2,3-dihydro-1h-benzo[e]indole(cbi), ainsi que des méthodes d'utilisation desdits conjugués anticorps-médicament.The invention relates to antibody-drug conjugates comprising an antibody conjugated with a 1- (chloromethyl) -2,3-dihydro-1H-benzo [e] indole dimeric drug moiety (cbi), as well as methods of using such conjugates antibody-drug.

MA38812A 2013-08-12 2014-06-16 1- (Chloromethyl) -2,3-dihydro-1H-benzo [e] indole antibody-drug conjugates, and methods of use and treatment MA38812B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361864889P 2013-08-12 2013-08-12
PCT/US2014/042560 WO2015023355A1 (en) 2013-08-12 2014-06-16 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment

Publications (2)

Publication Number Publication Date
MA38812A1 MA38812A1 (en) 2018-05-31
MA38812B1 true MA38812B1 (en) 2018-11-30

Family

ID=56125278

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38812A MA38812B1 (en) 2013-08-12 2014-06-16 1- (Chloromethyl) -2,3-dihydro-1H-benzo [e] indole antibody-drug conjugates, and methods of use and treatment

Country Status (2)

Country Link
AR (1) AR096626A1 (en)
MA (1) MA38812B1 (en)

Also Published As

Publication number Publication date
MA38812A1 (en) 2018-05-31
AR096626A1 (en) 2016-01-20

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