MA38789A1 - Pyrimidine-dione compounds against heart disease - Google Patents

Pyrimidine-dione compounds against heart disease

Info

Publication number
MA38789A1
MA38789A1 MA38789A MA38789A MA38789A1 MA 38789 A1 MA38789 A1 MA 38789A1 MA 38789 A MA38789 A MA 38789A MA 38789 A MA38789 A MA 38789A MA 38789 A1 MA38789 A1 MA 38789A1
Authority
MA
Morocco
Prior art keywords
heart disease
pyrimidine
dione compounds
compounds against
against heart
Prior art date
Application number
MA38789A
Other languages
French (fr)
Other versions
MA38789B1 (en
Inventor
Johan Oslob
Robert Anderson
Danielle Aubele
Marc Evanchik
Jonathan Charles Fox
Brian Kane
Puping Lu
Robert Mcdowell
Hector Rodriguez
Yonghong Song
Arvinder Sran
Original Assignee
Myokardia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Myokardia Inc filed Critical Myokardia Inc
Priority claimed from PCT/US2014/043192 external-priority patent/WO2014205223A1/en
Publication of MA38789A1 publication Critical patent/MA38789A1/en
Publication of MA38789B1 publication Critical patent/MA38789B1/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention concerne de nouveaux composés de pyrimidine-dione et des sels pharmaceutiquement acceptables de ceux-ci, qui sont utiles dans le traitement de la cardiomyopathie hypertrophique (hcm) et les affections associées à l'hypertrophie ventriculaire gauche ou à la dysfonction diastolique. La synthèse et la caractérisation des composés et de leurs sels pharmaceutiquement acceptables sont en outre décrites ainsi que des méthodes pour traiter la hcm et autres formes de maladie cardiaque.This invention relates to novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, which are useful in the treatment of hypertrophic cardiomyopathy (hcm) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and their pharmaceutically acceptable salts are further described as well as methods for treating hcm and other forms of heart disease.

MA38789A 2013-06-21 2014-06-19 Pyrimidine-dione compounds against heart disease MA38789B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361838088P 2013-06-21 2013-06-21
PCT/US2014/043192 WO2014205223A1 (en) 2013-06-21 2014-06-19 Pyrimidinedione compounds against cardiac conditions

Publications (2)

Publication Number Publication Date
MA38789A1 true MA38789A1 (en) 2017-08-31
MA38789B1 MA38789B1 (en) 2018-12-31

Family

ID=60450328

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38789A MA38789B1 (en) 2013-06-21 2014-06-19 Pyrimidine-dione compounds against heart disease

Country Status (1)

Country Link
MA (1) MA38789B1 (en)

Also Published As

Publication number Publication date
MA38789B1 (en) 2018-12-31

Similar Documents

Publication Publication Date Title
MA47079A (en) AMINO-TRIAZOLOPYIDINE COMPOUNDS AND THEIR USE TO TREAT CANCER
CR20210189A (en) Protein tyrosine phosphatase inhibitors
MX2022014414A (en) Pyrimidinedione compounds against cardiac conditions.
MA40123A1 (en) Pyrimidines used as factor xia inhibitors
MA39898B1 (en) 4-amino-imidazoquinoline compounds
MA40481A (en) PYRIDIN-2- (1H) -ONE-QUINOLINONE DERIVATIVES AS MUTANT ISOCITRATE DEHYDROGENASE INHIBITORS
MA34234B1 (en) PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE
MA44674B1 (en) Bromodomain inhibitors
MA33450B1 (en) Oxazin derivatives and used as basic inhibitors for the treatment of neurological disorders
MA42145B1 (en) Apj receptor agonist triazoles
MA40225A (en) SUBSTITUTED DIHYDROISOQUINOLINONE COMPOUNDS
MA39777B1 (en) Organic compounds of the monobactam family for the treatment of bacterial infections
NO20083568L (en) Hydantoin compounds for the treatment of inflammatory disorders
MA31358B1 (en) Ways to treat cancer using alpha pi3k inhibitors based on pyridoperimidone.
EA201190217A1 (en) SUBSTITUTED 2-ACETAMIDO-5-ARIL-1,2,4-TRIAZOLONES AND THEIR APPLICATION
UA111933C2 (en) PYROLOPYRIDINE AS KINASE INHIBITORS
BR112016015236A8 (en) compound, pharmaceutical composition, use of a compound, method of inhibition and method for treating or alleviating the severity of a disease.
PH12013502369A1 (en) Diazacarbazoles and methods of use
EP2498797A4 (en) Treatment of heart disease
EA201791656A1 (en) 4-Methylsulfonyl-substituted Piperidine Urea Compound for the Treatment of Dilated Cardiomyopathy (DCM)
EA201391720A1 (en) SUBSTITUTED DIOXOPIPERIDINYL-PHTHALIMIDE DERIVATIVES
MA38240B1 (en) Novel Iap antagonist substituted dimer compounds useful for the treatment of cancer, preferably solid tumors
MA39926B1 (en) Cycloalkyl-linked diheterocycle derivatives
MA38009B1 (en) Substituted azaindoline compounds which have an inhibitory activity of the apoptosis protein for their uses in the treatment and / or prophylaxis of cancer
MA38789A1 (en) Pyrimidine-dione compounds against heart disease