MA38417B1 - Substituted oxopyridine Derivatives and Use of Such Derivatives in the Treatment of Cardiovascular Diseases - Google Patents

Substituted oxopyridine Derivatives and Use of Such Derivatives in the Treatment of Cardiovascular Diseases

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Publication number
MA38417B1
MA38417B1 MA38417A MA38417A MA38417B1 MA 38417 B1 MA38417 B1 MA 38417B1 MA 38417 A MA38417 A MA 38417A MA 38417 A MA38417 A MA 38417A MA 38417 B1 MA38417 B1 MA 38417B1
Authority
MA
Morocco
Prior art keywords
derivatives
treatment
diseases
oxopyridine
cardiovascular diseases
Prior art date
Application number
MA38417A
Other languages
French (fr)
Other versions
MA38417A1 (en
Inventor
Adrian Tersteegen
Martina Schäfer
Susanne Röhrig
Alexander Hillisch
Julia Strassburger
Stefan Heitmeier
Martina Victoria Schmidt
Karl-Heinz Schlemmer
Anja Buchmüller
Christoph Gerdes
Tom Kinzel
Henrik Teller
Hartmut Schirok
Jürgen Klar
Nunez Eloisa Jimenez
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Priority claimed from PCT/EP2014/056135 external-priority patent/WO2014154794A1/en
Publication of MA38417A1 publication Critical patent/MA38417A1/en
Publication of MA38417B1 publication Critical patent/MA38417B1/en

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Abstract

L'invention concerne des dérivés de l'oxopyridine subsitués de la formule, dans laquelle : r1 représente un groupe de la formule, * représentant le point de liaison au composé cyclique de l'oxopyridine ; r6 représente du brome, du chlore, du fluor, un groupe méthyle, difluorométhyle, trifluorométhyle, méthoxy, difluorométhoxy ou trifluorométhoxy ; r7 représente du brome, du chlore, du fluor, un groupe cyano, nitro, hydroxy, méthyle, difluorométhyle, trifluorométhyle, méthoxy, éthoxy, difluorométhoxy ou trifluorométhoxy, un groupe éthinyle, un 3,3,3-trifluoroprop-l-in-l-yl ou un groupe cyclopropyle. L'invention concerne également un procédé servant à fabriquer lesdits dérivés de l'oxopyridine, ainsi que leur utilisation pour la fabrication de médicaments servant au traitement et/ou à la prophylaxie de maladies, en particulier de maladies cardiovasculaires, de préférence de maladies thrombotiques ou thrombo-emboliques ou d'oedèmes, ainsi qu'au traitement et/ou à la prophylaxie de maladies ophtalmologiques.The invention relates to substituted oxopyridine derivatives of the formula, wherein: r1 represents a group of the formula, * representing the point of attachment to the cyclic compound of oxopyridine; r6 represents bromine, chlorine, fluorine, methyl, difluoromethyl, trifluoromethyl, methoxy, difluoromethoxy or trifluoromethoxy; r7 is bromine, chlorine, fluorine, cyano, nitro, hydroxy, methyl, difluoromethyl, trifluoromethyl, methoxy, ethoxy, difluoromethoxy or trifluoromethoxy, ethinyl, 3,3,3-trifluoroprop-1-1 1-yl or a cyclopropyl group. The invention also relates to a process for producing said oxopyridine derivatives and their use for the manufacture of medicaments for the treatment and / or prophylaxis of diseases, in particular cardiovascular diseases, preferably thrombotic diseases or thromboembolism or edema, and the treatment and / or prophylaxis of ophthalmological diseases.

MA38417A 2013-03-28 2014-03-27 Substituted oxopyridine Derivatives and Use of Such Derivatives in the Treatment of Cardiovascular Diseases MA38417B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13161588 2013-03-28
PCT/EP2014/056135 WO2014154794A1 (en) 2013-03-28 2014-03-27 Substituted oxopyridine derivatives and use thereof in the treatment of cardiovascular disorders

Publications (2)

Publication Number Publication Date
MA38417A1 MA38417A1 (en) 2017-02-28
MA38417B1 true MA38417B1 (en) 2017-10-31

Family

ID=47997233

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38417A MA38417B1 (en) 2013-03-28 2014-03-27 Substituted oxopyridine Derivatives and Use of Such Derivatives in the Treatment of Cardiovascular Diseases

Country Status (2)

Country Link
AR (1) AR095921A1 (en)
MA (1) MA38417B1 (en)

Also Published As

Publication number Publication date
AR095921A1 (en) 2015-11-25
MA38417A1 (en) 2017-02-28

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