MA38280A1 - Substituted 1,2,3,4-tetrahydroisoquinoline compounds inhibiting arginine-methyltransferase protein 5 - Google Patents

Substituted 1,2,3,4-tetrahydroisoquinoline compounds inhibiting arginine-methyltransferase protein 5

Info

Publication number
MA38280A1
MA38280A1 MA38280A MA38280A MA38280A1 MA 38280 A1 MA38280 A1 MA 38280A1 MA 38280 A MA38280 A MA 38280A MA 38280 A MA38280 A MA 38280A MA 38280 A1 MA38280 A1 MA 38280A1
Authority
MA
Morocco
Prior art keywords
substituted
compounds inhibiting
methyltransferase protein
tetrahydroisoquinoline compounds
compounds
Prior art date
Application number
MA38280A
Other languages
French (fr)
Other versions
MA38280B1 (en
Inventor
Kenneth W Duncan
Richard Chesworth
Paula Ann Boriack-Sjodin
Michael John Munchhof
Original Assignee
Epizyme Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epizyme Inc filed Critical Epizyme Inc
Priority claimed from PCT/US2013/077235 external-priority patent/WO2014100719A2/en
Publication of MA38280A1 publication Critical patent/MA38280A1/en
Publication of MA38280B1 publication Critical patent/MA38280B1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés de formule (a), des sels pharmaceutiquement acceptables de ceux-ci et des compositions pharmaceutiques de ceux-ci. Les composés de la présente invention sont utiles pour inhiber l'activité de prmt5. L'invention concerne également des procédés d'utilisation de composés pour le traitement de troubles médiés par prmt5.The invention relates to compounds of formula (a), pharmaceutically acceptable salts thereof and pharmaceutical compositions thereof. The compounds of the present invention are useful for inhibiting prmt5 activity. The invention also relates to methods of using compounds for the treatment of prmt5 mediated disorders.

MA38280A 2012-12-21 2013-12-20 Substituted 1,2,3,4-tetrahydroisoquinoline compounds inhibiting arginine-methyltransferase protein 5 MA38280B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261745485P 2012-12-21 2012-12-21
PCT/US2013/077235 WO2014100719A2 (en) 2012-12-21 2013-12-20 Prmt5 inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
MA38280A1 true MA38280A1 (en) 2017-10-31
MA38280B1 MA38280B1 (en) 2018-12-31

Family

ID=60765488

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38280A MA38280B1 (en) 2012-12-21 2013-12-20 Substituted 1,2,3,4-tetrahydroisoquinoline compounds inhibiting arginine-methyltransferase protein 5

Country Status (1)

Country Link
MA (1) MA38280B1 (en)

Also Published As

Publication number Publication date
MA38280B1 (en) 2018-12-31

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