MA38136A1 - Treatment or prevention of cardiovascular events by administration of a colchicine derivative - Google Patents
Treatment or prevention of cardiovascular events by administration of a colchicine derivativeInfo
- Publication number
- MA38136A1 MA38136A1 MA38136A MA38136A MA38136A1 MA 38136 A1 MA38136 A1 MA 38136A1 MA 38136 A MA38136 A MA 38136A MA 38136 A MA38136 A MA 38136A MA 38136 A1 MA38136 A1 MA 38136A1
- Authority
- MA
- Morocco
- Prior art keywords
- group
- alkyl
- optionally substituted
- formula
- independently represent
- Prior art date
Links
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical class C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 title abstract 2
- 230000007211 cardiovascular event Effects 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 125000004442 acylamino group Chemical group 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 abstract 1
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 230000003143 atherosclerotic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000019553 vascular disease Diseases 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La présente invention concerne un procédé de traitement ou de prévention d'un événement cardiovasculaire chez un sujet atteint d'une maladie vasculaire athérosclérotique, ledit procédé comprenant l'étape suivante : b) administration d'une quantité thérapeutiquement efficace d'un composé de formule (i), d'un dérivé connu de colchicine et/ou d'un sel de celui-ci où : r1, r2, r3, r4, r9, r10, r11 et r12 représentent indépendamment un atome d'hydrogène, un groupe alkyle en c1-4, un groupe alcényle en c2-4, un groupe cycloalkyle en c3-6, un atome d'halogène, un groupe haloalkyle en c1-4, un groupe nitro, un groupe amino, un groupe acylamino en c2-4, un groupe dialkylamino ou alkyle en c1-4, un groupe hydroxyle, un groupe alcoxy en c1-4, un groupe alkylthio en c1-4, un groupe de formule -so2n(rx)2 ou so2rx dans laquelle rx est un groupe alkyle en c1-4, un groupe acyloxy en c1-4, ou un groupe phényle facultativement substitué, un groupe phénoxy facultativement substitué ; r7 et r8 représentent indépendamment un atome d'hydrogène, un groupe alkyle en c1-4 ou un groupe acyle en c1-4 ; et r5', r5", r6' et r6" représentent indépendamment un atome d'hydrogène, un groupe alkyle en c1-4, un groupe alcényle en c2-4, un groupe cycloalkyle en c3-6, un atome d'halogène, un groupe haloalkyle en c1-4, un groupe nitro, un groupe amino, un groupe acylamino en c2-4, un groupe hydroxyle, un groupe alcoxy en c1-4 ou un groupe alkylthio en c1-4, un groupe de formule - so2n(rx)2 ou so2rx dans laquelle rx est un groupe alkyle en c1-4, un groupe acyloxy en c1-4, ou un groupe phényle facultativement substitué.The present invention relates to a method for treating or preventing a cardiovascular event in a subject suffering from atherosclerotic vascular disease, said method comprising the following step: b) administering a therapeutically effective amount of a compound of formula (i) a known derivative of colchicine and / or a salt thereof wherein: r1, r2, r3, r4, r9, r10, r11 and r12 independently represent a hydrogen atom, an alkyl group in C 1-4, a C 2-4 alkenyl group, a C 3-6 cycloalkyl group, a halogen atom, a C 1-4 haloalkyl group, a nitro group, an amino group, a C 2-4 acylamino group; , a dialkylamino or C1-4 alkyl group, a hydroxyl group, a C1-4 alkoxy group, a C1-4 alkylthio group, a group of the formula -so2n (rx) 2 or so2rx wherein rx is an alkyl group at C1-4, a C1-4 acyloxy group, or an optionally substituted phenyl group, an optionally substituted phenoxy group ue; r7 and r8 independently represent a hydrogen atom, a C1-4 alkyl group or a C1-4 acyl group; and R5 ', R5 ", R6' and R6" independently represent a hydrogen atom, a C1-4 alkyl group, a C2-4 alkenyl group, a C3-6 cycloalkyl group, a halogen atom, a C1-4 haloalkyl group, a nitro group, an amino group, a C2-4 acylamino group, a hydroxyl group, a C1-4 alkoxy group or a C1-4 alkylthio group, a group of the formula - so2n (rx) 2 or so2rx wherein rx is a C1-4 alkyl group, a C1-4 acyloxy group, or an optionally substituted phenyl group.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2012904828A AU2012904828A0 (en) | 2012-11-02 | Treatment and Prevention of Coronary Thrombosis | |
| PCT/AU2013/001261 WO2014066944A1 (en) | 2012-11-02 | 2013-11-01 | Treatment or prevention of cardiovascular events via the administration of a colchicine derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA38136A1 true MA38136A1 (en) | 2017-08-31 |
| MA38136B1 MA38136B1 (en) | 2019-03-29 |
Family
ID=60450322
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA44940A MA44940B1 (en) | 2012-11-02 | 2013-11-01 | Treatment or prevention of cardiovascular events by administration of a colchicine derivative |
| MA38136A MA38136B1 (en) | 2012-11-02 | 2013-11-01 | Treatment or prevention of cardiovascular events by administration of a colchicine derivative |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA44940A MA44940B1 (en) | 2012-11-02 | 2013-11-01 | Treatment or prevention of cardiovascular events by administration of a colchicine derivative |
Country Status (1)
| Country | Link |
|---|---|
| MA (2) | MA44940B1 (en) |
-
2013
- 2013-11-01 MA MA44940A patent/MA44940B1/en unknown
- 2013-11-01 MA MA38136A patent/MA38136B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MA44940A1 (en) | 2020-05-29 |
| MA38136B1 (en) | 2019-03-29 |
| MA44940B1 (en) | 2022-04-29 |
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