MA38075A1 - Orexin receptor antagonists, which are [ortho bi (hetero) aryl] - [2- (meta-bi (hetero) aryl) -pyrrolidin-1-yl] -methanone derivatives - Google Patents

Orexin receptor antagonists, which are [ortho bi (hetero) aryl] - [2- (meta-bi (hetero) aryl) -pyrrolidin-1-yl] -methanone derivatives

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Publication number
MA38075A1
MA38075A1 MA38075A MA38075A MA38075A1 MA 38075 A1 MA38075 A1 MA 38075A1 MA 38075 A MA38075 A MA 38075A MA 38075 A MA38075 A MA 38075A MA 38075 A1 MA38075 A1 MA 38075A1
Authority
MA
Morocco
Prior art keywords
hetero
aryl
pyrrolidin
ortho
meta
Prior art date
Application number
MA38075A
Other languages
French (fr)
Inventor
Martin Bolli
Christoph Boss
Christine Brotschi
Bibia Heidmann
Thierry Sifferlen
Jodi T Williams
Markus Gude
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Priority claimed from PCT/IB2013/059233 external-priority patent/WO2014057435A1/en
Publication of MA38075A1 publication Critical patent/MA38075A1/en

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Abstract

La présente invention concerne des dérivés [ortho bi-(hétéro-)aryl]-[2-(méta bi-(hétéro-)aryl)-pyrrolidin-1-yl]- méthanone de la formule (i) dans laquelle r, et les cycles a1a2 et a3 sont tels que définis dans la description, leurs sels pharmaceutiquement acceptables, leur préparation, des compositions pharmaceutiques contenant au moins un composé de la formule (i), et leur utilisation comme médicaments, en particulier comme antagonistes des récepteurs de l'oréxine.The present invention relates to [ortho-bis (hetero) aryl] - [2- (meta-b (hetero) aryl) -pyrrolidin-1-yl] -methanone derivatives of the formula (i) wherein r, and the rings a1a2 and a3 are as defined in the description, their pharmaceutically acceptable salts, their preparation, pharmaceutical compositions containing at least one compound of the formula (i), and their use as medicaments, in particular as antagonists of the 'orexin.

MA38075A 2012-10-10 2013-10-09 Orexin receptor antagonists, which are [ortho bi (hetero) aryl] - [2- (meta-bi (hetero) aryl) -pyrrolidin-1-yl] -methanone derivatives MA38075A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12188019 2012-10-10
PCT/IB2013/059233 WO2014057435A1 (en) 2012-10-10 2013-10-09 Orexin receptor antagonists which are [ortho bi (hetero )aryl]-[2-(meta bi (hetero )aryl)-pyrrolidin-1-yl]-methanone derivatives

Publications (1)

Publication Number Publication Date
MA38075A1 true MA38075A1 (en) 2017-11-30

Family

ID=47073302

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38075A MA38075A1 (en) 2012-10-10 2013-10-09 Orexin receptor antagonists, which are [ortho bi (hetero) aryl] - [2- (meta-bi (hetero) aryl) -pyrrolidin-1-yl] -methanone derivatives

Country Status (1)

Country Link
MA (1) MA38075A1 (en)

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