MA37464A1 - Anti-egfr antibodies and their uses - Google Patents

Anti-egfr antibodies and their uses

Info

Publication number
MA37464A1
MA37464A1 MA37464A MA37464A MA37464A1 MA 37464 A1 MA37464 A1 MA 37464A1 MA 37464 A MA37464 A MA 37464A MA 37464 A MA37464 A MA 37464A MA 37464 A1 MA37464 A1 MA 37464A1
Authority
MA
Morocco
Prior art keywords
antibodies
egfr
bind
present
egfr antibodies
Prior art date
Application number
MA37464A
Other languages
French (fr)
Other versions
MA37464B1 (en
Inventor
Christopher Daly
Gavin Thurston
Nicholas J Papadopoulos
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Priority claimed from PCT/US2013/047476 external-priority patent/WO2014004427A2/en
Publication of MA37464A1 publication Critical patent/MA37464A1/en
Publication of MA37464B1 publication Critical patent/MA37464B1/en

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne des anticorps qui se lient à egfr et des procédés de son utilisation. Selon certains modes de réalisation de l'invention, les anticorps sont des anticorps complètement humains qui se lient à l'egfr humain avec une affinité élevée. Dans certains modes de réalisation, les anticorps de la présente invention sont aptes à inhiber la croissance de cellules tumorales exprimant des taux élevés d'egfr et/ou induisant une cytotoxicité à médiation cellulaire dépendante d'un anticorps (adcc) de telles cellules. Les anticorps de l'invention sont utiles pour le traitement de divers cancers, ainsi que pour d'autres troubles associés à egfr.The present invention relates to antibodies that bind to egfr and methods of its use. According to some embodiments of the invention, the antibodies are fully human antibodies that bind to human egfr with high affinity. In some embodiments, the antibodies of the present invention are capable of inhibiting the growth of tumor cells expressing high levels of egfr and / or inducing antibody-dependent cell-mediated cytotoxicity (adcc) of such cells. The antibodies of the invention are useful for the treatment of various cancers, as well as for other egfr-associated disorders.

MA37464A 2012-06-25 2013-06-25 Anti-egfr antibodies and their uses MA37464B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261663984P 2012-06-25 2012-06-25
PCT/US2013/047476 WO2014004427A2 (en) 2012-06-25 2013-06-25 Anti-egfr antibodies and uses thereof

Publications (2)

Publication Number Publication Date
MA37464A1 true MA37464A1 (en) 2016-03-31
MA37464B1 MA37464B1 (en) 2018-03-30

Family

ID=56073199

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37464A MA37464B1 (en) 2012-06-25 2013-06-25 Anti-egfr antibodies and their uses

Country Status (1)

Country Link
MA (1) MA37464B1 (en)

Also Published As

Publication number Publication date
MA37464B1 (en) 2018-03-30

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