MA35814B1 - 2- (chroman-6-yloxy) substituted thiazoles and their use as pharmaceuticals - Google Patents

2- (chroman-6-yloxy) substituted thiazoles and their use as pharmaceuticals

Info

Publication number
MA35814B1
MA35814B1 MA36819A MA36819A MA35814B1 MA 35814 B1 MA35814 B1 MA 35814B1 MA 36819 A MA36819 A MA 36819A MA 36819 A MA36819 A MA 36819A MA 35814 B1 MA35814 B1 MA 35814B1
Authority
MA
Morocco
Prior art keywords
chroman
yloxy
pharmaceuticals
formula
substituted thiazoles
Prior art date
Application number
MA36819A
Other languages
French (fr)
Inventor
Werngard Czechtizky
John Weston
Nils Rackelmann
Michael Podeschwa
Petra Arndt
Klaus Wirth
Heinz Goegelein
Olaf Ritzeler
Volker Kraft
Patrice Bellevergue
Gary Mccort
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MA35814B1 publication Critical patent/MA35814B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des thiazoles à substitution 2-(chroman-6-yloxy) de formule (i), dans laquelle ar, r2, r3 et r4 sont tels que définis dans les revendications. Les composés de formule (i) sont des inhibiteurs de l'échangeur sodium-calcium (ncx), particulièrement de l'échangeur sodium-calcium de sous-type 1 (ncx1), et sont appropriés pour le traitement de divers troubles dans lesquels l'homéostasie du calcium intracellulaire est perturbée, comme les arythmies, l'insuffisance cardiaque et l'accident vasculaire cérébral. L'invention concerne en outre des procédés de préparation de composé de formule (i), leur utilisation comme produits pharmaceutiques, et des compositions pharmaceutiques les comprenant.The present invention relates to 2- (chroman-6-yloxy) substituted thiazoles of formula (i), wherein ar, r2, r3 and r4 are as defined in the claims. The compounds of formula (i) are inhibitors of the sodium-calcium exchanger (ncx), particularly of the sodium-calcium exchanger of subtype 1 (ncx1), and are suitable for the treatment of various disorders in which Intracellular calcium homeostasis is disrupted, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for preparing a compound of formula (i), their use as pharmaceuticals, and pharmaceutical compositions comprising them.

MA36819A 2011-09-12 2014-03-12 2- (chroman-6-yloxy) substituted thiazoles and their use as pharmaceuticals MA35814B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2011/065712 WO2013037388A1 (en) 2011-09-12 2011-09-12 Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals

Publications (1)

Publication Number Publication Date
MA35814B1 true MA35814B1 (en) 2014-12-01

Family

ID=44645708

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36819A MA35814B1 (en) 2011-09-12 2014-03-12 2- (chroman-6-yloxy) substituted thiazoles and their use as pharmaceuticals

Country Status (8)

Country Link
KR (1) KR101817925B1 (en)
AU (1) AU2011376746B2 (en)
CA (1) CA2846347C (en)
IL (1) IL231096A (en)
MA (1) MA35814B1 (en)
SG (1) SG11201400518RA (en)
WO (1) WO2013037388A1 (en)
ZA (1) ZA201401335B (en)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4168380A (en) 1978-04-21 1979-09-18 Hoffmann-La Roche Inc. 7-Methoxy-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid
JPH0967336A (en) 1995-09-04 1997-03-11 Kanebo Ltd New isothiourea derivative
US6156801A (en) 1997-03-27 2000-12-05 Taisho Pharmaceutical Co., Ltd. 2-phenoxyaniline derivatives
ATE309241T1 (en) 1999-09-10 2005-11-15 Merck & Co Inc TYROSINE KINASE INHIBITORS
AU2001295951A1 (en) 2000-10-18 2002-04-29 Senju Pharmaceutical Co. Ltd. Novel 4-benzyloxyphenyl derivative and use thereof
FI20011507A0 (en) 2001-07-10 2001-07-10 Orion Corp New compounds
AU2003244181A1 (en) 2002-06-25 2004-01-06 Yamanouchi Pharmaceutical Co., Ltd. Phenoxypyridine derivative or salt thereof
FI20030030A0 (en) 2003-01-09 2003-01-09 Orion Corp New compounds
JP5092111B2 (en) 2007-02-05 2012-12-05 トーアエイヨー株式会社 Butoxyaniline derivatives
EP2103939A1 (en) 2008-03-20 2009-09-23 sanofi-aventis Fluorescence based assay to detect sodium/calcium exchanger (NCX) "reverse mode" modulating compounds
EP2348859B1 (en) 2008-10-01 2013-12-04 Merck Sharp & Dohme Corp. Prodrugs of oxazolidinone cetp inhibitors

Also Published As

Publication number Publication date
CA2846347A1 (en) 2013-03-21
AU2011376746A1 (en) 2014-03-20
ZA201401335B (en) 2015-08-26
KR101817925B1 (en) 2018-01-12
KR20140063807A (en) 2014-05-27
AU2011376746B2 (en) 2017-06-15
CA2846347C (en) 2019-05-21
SG11201400518RA (en) 2014-04-28
WO2013037388A1 (en) 2013-03-21
IL231096A0 (en) 2014-03-31
IL231096A (en) 2017-07-31

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