MA32049B1 - Treatment of cancer with compounds inhibitors and topoisomerase barb inhibitors - Google Patents

Treatment of cancer with compounds inhibitors and topoisomerase barb inhibitors

Info

Publication number
MA32049B1
MA32049B1 MA32986A MA32986A MA32049B1 MA 32049 B1 MA32049 B1 MA 32049B1 MA 32986 A MA32986 A MA 32986A MA 32986 A MA32986 A MA 32986A MA 32049 B1 MA32049 B1 MA 32049B1
Authority
MA
Morocco
Prior art keywords
inhibitors
topoisomerase
cancer
treatment
barb
Prior art date
Application number
MA32986A
Other languages
Arabic (ar)
French (fr)
Inventor
Valeria S Ossovskaya
Charles Bradley
Barry M Sherman
Original Assignee
Bipar Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bipar Sciences Inc filed Critical Bipar Sciences Inc
Publication of MA32049B1 publication Critical patent/MA32049B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Selon un aspect, la présente invention a trait à une composition et à un kit comprenant une combinaison d'inhibiteur de topoïsomérase et d'inhibiteur de parp pour le traitement du cancer. Selon un autre aspect, l'invention a trait à un procédé permettant de traiter le cancer qui comprend l'étape consistant à administrer à un sujet une combinaison d'inhibiteur de topoïsomérase et d'inhibiteur deparp. En particulier, l'invention a trait à des compositions et à des procédés permettant de traiter le cancer chez un sujet en inhibant une poly(adp-ribose) polymérase et une topoïsomérase, tout en fournissant des formulations et des modes d'administration de ces compositions.In one aspect, the present invention provides a composition and kit comprising a combination of topoisomerase inhibitor and parp inhibitor for the treatment of cancer. In another aspect, the invention provides a method of treating cancer which comprises the step of administering to a subject a combination of topoisomerase inhibitor and deparp inhibitor. In particular, the invention relates to compositions and methods for treating cancer in a subject by inhibiting a poly (adp-ribose) polymerase and a topoisomerase, while providing formulations and methods of administration thereof. compositions.

MA32986A 2007-12-07 2010-07-05 Treatment of cancer with compounds inhibitors and topoisomerase barb inhibitors MA32049B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1236407P 2007-12-07 2007-12-07
PCT/US2008/085756 WO2009073869A1 (en) 2007-12-07 2008-12-05 Treatment of cancer with combinations of topoisomerase inhibitors and parp inhibitors

Publications (1)

Publication Number Publication Date
MA32049B1 true MA32049B1 (en) 2011-02-01

Family

ID=40718219

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32986A MA32049B1 (en) 2007-12-07 2010-07-05 Treatment of cancer with compounds inhibitors and topoisomerase barb inhibitors

Country Status (13)

Country Link
US (1) US20090149397A1 (en)
EP (1) EP2224804A4 (en)
JP (1) JP2011506343A (en)
KR (1) KR20100102637A (en)
CN (1) CN101888777A (en)
AU (1) AU2008333786A1 (en)
CA (1) CA2708157A1 (en)
CO (1) CO6321188A2 (en)
IL (1) IL206209A0 (en)
MA (1) MA32049B1 (en)
MX (1) MX2010006154A (en)
RU (1) RU2010128107A (en)
WO (1) WO2009073869A1 (en)

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US20090149397A1 (en) 2009-06-11
RU2010128107A (en) 2012-01-20
CA2708157A1 (en) 2009-06-11
AU2008333786A1 (en) 2009-06-11
EP2224804A1 (en) 2010-09-08
CN101888777A (en) 2010-11-17

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