MA31703B1 - PYRIDINE DERIVATIVES AS MODULATORS OF THE S1P1 / EDG1 RECEPTOR - Google Patents
PYRIDINE DERIVATIVES AS MODULATORS OF THE S1P1 / EDG1 RECEPTORInfo
- Publication number
- MA31703B1 MA31703B1 MA32693A MA32693A MA31703B1 MA 31703 B1 MA31703 B1 MA 31703B1 MA 32693 A MA32693 A MA 32693A MA 32693 A MA32693 A MA 32693A MA 31703 B1 MA31703 B1 MA 31703B1
- Authority
- MA
- Morocco
- Prior art keywords
- pyridine derivatives
- modulators
- edg1 receptor
- formula
- edg1
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
L'invention concerne de nouveaux dérivés pyridiniques de formule (i), leur préparation et leur utilisation comme composés pharmaceutiquement actifs. Lesdits composés agissent notamment comme agents immunomodulateurs. Dans la formule (i), a et les autres substituants sont tels que définis dans les revendications.The invention relates to novel pyridine derivatives of formula (i), their preparation and their use as pharmaceutically active compounds. Said compounds act in particular as immunomodulatory agents. In formula (i), a and the other substituents are as defined in the claims.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2007053293 | 2007-08-17 | ||
| PCT/IB2008/053269 WO2009024905A1 (en) | 2007-08-17 | 2008-08-14 | Pyridine derivatives as s1p1/edg1 receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA31703B1 true MA31703B1 (en) | 2010-09-01 |
Family
ID=40193868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA32693A MA31703B1 (en) | 2007-08-17 | 2010-03-12 | PYRIDINE DERIVATIVES AS MODULATORS OF THE S1P1 / EDG1 RECEPTOR |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8598208B2 (en) |
| EP (1) | EP2195311B1 (en) |
| JP (1) | JP5451614B2 (en) |
| KR (1) | KR101541558B1 (en) |
| CN (1) | CN102648198B (en) |
| AR (1) | AR067977A1 (en) |
| AT (1) | ATE502938T1 (en) |
| AU (1) | AU2008290233B2 (en) |
| BR (1) | BRPI0815190A2 (en) |
| CA (1) | CA2695509A1 (en) |
| CY (1) | CY1111830T1 (en) |
| DE (1) | DE602008005770D1 (en) |
| DK (1) | DK2195311T3 (en) |
| ES (1) | ES2361463T3 (en) |
| HK (1) | HK1144809A1 (en) |
| HR (1) | HRP20110449T1 (en) |
| MA (1) | MA31703B1 (en) |
| MX (1) | MX2010001881A (en) |
| MY (1) | MY153975A (en) |
| NZ (1) | NZ583957A (en) |
| PL (1) | PL2195311T3 (en) |
| PT (1) | PT2195311E (en) |
| RU (1) | RU2492168C2 (en) |
| SI (1) | SI2195311T1 (en) |
| TW (1) | TWI422373B (en) |
| WO (1) | WO2009024905A1 (en) |
| ZA (1) | ZA201001873B (en) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI392671B (en) * | 2006-09-07 | 2013-04-11 | Actelion Pharmaceuticals Ltd | Pyridin-4-yl derivatives |
| PL2069335T3 (en) | 2006-09-08 | 2013-05-31 | Actelion Pharmaceuticals Ltd | Pyridin-3-yl derivatives as immunomodulating agents |
| EP2079734A1 (en) * | 2006-10-25 | 2009-07-22 | NeuroSearch A/S | Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators |
| DK2125797T3 (en) * | 2007-03-16 | 2014-02-10 | Actelion Pharmaceuticals Ltd | AMINOPYRIDINE DERIVATIVES AS S1P1 / EDG1 RECEPTOR AGONISTS |
| KR101615779B1 (en) * | 2008-03-07 | 2016-04-26 | 액테리온 파마슈티칼 리미티드 | Pyridin-2-yl derivatives as immunomodulating agents |
| KR101718639B1 (en) | 2008-03-17 | 2017-03-21 | 액테리온 파마슈티칼 리미티드 | Dosing Regimen for a Selective S1P1 Receptor Agonist |
| SG175855A1 (en) * | 2009-05-04 | 2011-12-29 | Prometic Biosciences Inc | Substituted aromatic compounds and pharmaceutical uses thereof |
| RU2547098C2 (en) | 2009-07-16 | 2015-04-10 | Актелион Фармасьютиклз Лтд | Pyrimidin-4-yl derivatives |
| WO2012098505A1 (en) | 2011-01-19 | 2012-07-26 | Actelion Pharmaceuticals Ltd | 2-methoxy-pyridin-4-yl derivatives |
| EP2844655A1 (en) | 2012-05-02 | 2015-03-11 | Lupin Limited | Substituted pyridine compounds as crac modulators |
| MX350891B (en) | 2012-08-17 | 2017-09-22 | Actelion Pharmaceuticals Ltd | Process for the preparation of|(2z,5z)-5-(3-chloro-4-((r)-2,3-dih ydroxypropoxy)benzylidene)-2-(propylimino)-3-|(o-tolyl)thiazolid in-4-one and intermediate used in said process. |
| NZ713080A (en) | 2013-03-15 | 2020-06-26 | Idorsia Pharmaceuticals Ltd | Pyridin-4-yl derivatives |
| HUE047646T2 (en) | 2015-05-20 | 2020-05-28 | Idorsia Pharmaceuticals Ltd | Crystalline form of the compound (s)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol |
| US10111841B2 (en) | 2015-06-19 | 2018-10-30 | University Of South Florida | Stabilization of alcohol intoxication-induced cardiovascular instability |
| WO2017004609A1 (en) | 2015-07-02 | 2017-01-05 | Exelixis, Inc. | Thiadiazole modulators of s1p and methods of making and using |
| WO2017004610A1 (en) | 2015-07-02 | 2017-01-05 | Exelixis, Inc. | Tercyclic s1p3-sparing, s1p1 receptor agonists |
| WO2017004608A1 (en) | 2015-07-02 | 2017-01-05 | Exelixis, Inc. | Oxadiazole modulators of s1p methods of making and using |
| EA201891644A1 (en) | 2016-03-07 | 2019-04-30 | Зе Глобал Эллайенс Фо Тб Драг Девелопмент, Инк. | ANTIBACTERIAL CONNECTIONS AND THEIR APPLICATION |
| TW201808906A (en) | 2016-03-16 | 2018-03-16 | 拜耳作物科學股份有限公司 | Substituted pyridine compounds as pesticides |
| US11014940B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Thiazolidinone and oxazolidinone compounds and formulations |
| US11013723B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms of a thiazolidinone compound, compositions and methods of use thereof |
| US11014897B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof |
| US11186556B1 (en) | 2018-10-16 | 2021-11-30 | Celgene Corporation | Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof |
| EP4211112A1 (en) * | 2020-09-11 | 2023-07-19 | PI Industries Ltd. | A process for the preparation of substituted pyridine compounds and intermediates thereof |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3647809A (en) * | 1968-04-26 | 1972-03-07 | Chinoin Gyogyszer Es Vegyeszet | Certain pyridyl-1 2 4-oxadiazole derivatives |
| AU7686891A (en) | 1990-04-05 | 1991-10-30 | American National Red Cross, The | A protein family related to immediate-early protein expressed by human endothelial cells during differentiation |
| US6423508B1 (en) | 1998-03-09 | 2002-07-23 | Smithkline Beecham Corporation | Polynucleotide sequences of human EDG-1c |
| NZ517221A (en) | 1999-08-19 | 2004-01-30 | Nps Pharma Inc | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| MXPA03007513A (en) | 2001-02-21 | 2004-07-30 | Nps Pharma Inc | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists. |
| JP4709488B2 (en) | 2002-01-18 | 2011-06-22 | メルク・シャープ・エンド・ドーム・コーポレイション | N- (benzyl) aminoalkylcarboxylic acid compounds, phosphinic acid compounds, phosphonic acid compounds and tetrazoles as Edg receptor agonists |
| EP1470137B1 (en) | 2002-01-18 | 2009-09-02 | Merck & Co., Inc. | Edg receptor agonists |
| WO2004035538A1 (en) | 2002-10-15 | 2004-04-29 | Merck & Co., Inc. | Process for making azetidine-3-carboxylic acid |
| US20060252741A1 (en) * | 2003-05-15 | 2006-11-09 | Colandrea Vincent J | 3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as s1p receptor agonists |
| CN1859908A (en) | 2003-10-01 | 2006-11-08 | 默克公司 | 3,5-aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as S1P receptor agonists |
| CA2547198A1 (en) * | 2003-12-17 | 2005-06-30 | Merck & Co., Inc. | (3,4-disubstituted)propanoic carboxylates as s1p (edg) receptor agonists |
| MXPA06013912A (en) | 2004-05-29 | 2007-07-18 | 7Tm Pharma As | Crth2 receptor ligands for medicinal uses. |
| CN101160285A (en) | 2005-03-17 | 2008-04-09 | 辉瑞大药厂 | Substituted sulfonylaminoarylmethyl cyclopropanecarboxamide as vr1 receptor antagonists |
| AU2006239418A1 (en) | 2005-04-26 | 2006-11-02 | Neurosearch A/S | Novel oxadiazole derivatives and their medical use |
| CA2610310A1 (en) | 2005-06-08 | 2006-12-14 | Novartis Ag | Polycyclic oxadiazoles or isoxazoles and their use as s1p receptor ligands |
| WO2007001973A1 (en) | 2005-06-28 | 2007-01-04 | Astrazeneca Ab | New use |
| TWI404706B (en) * | 2006-01-11 | 2013-08-11 | Actelion Pharmaceuticals Ltd | Novel thiophene derivatives |
| ES2335242T3 (en) * | 2006-01-24 | 2010-03-23 | Actelion Pharmaceuticals Ltd. | NEW PIRIDINE DERIVATIVES. |
| GB0601744D0 (en) | 2006-01-27 | 2006-03-08 | Novartis Ag | Organic compounds |
| TWI392671B (en) * | 2006-09-07 | 2013-04-11 | Actelion Pharmaceuticals Ltd | Pyridin-4-yl derivatives |
| PL2069335T3 (en) * | 2006-09-08 | 2013-05-31 | Actelion Pharmaceuticals Ltd | Pyridin-3-yl derivatives as immunomodulating agents |
| ES2393412T3 (en) * | 2006-09-21 | 2012-12-21 | Actelion Pharmaceuticals Ltd. | Phenyl derivatives and their use as immunomodulators |
| NZ577111A (en) | 2006-12-15 | 2012-05-25 | Abbott Lab | Novel oxadiazole compounds |
| DK2125797T3 (en) * | 2007-03-16 | 2014-02-10 | Actelion Pharmaceuticals Ltd | AMINOPYRIDINE DERIVATIVES AS S1P1 / EDG1 RECEPTOR AGONISTS |
| AU2008320374A1 (en) * | 2007-11-01 | 2009-05-07 | Actelion Pharmaceuticals Ltd | Novel pyrimidine derivatives |
| WO2009109907A1 (en) * | 2008-03-06 | 2009-09-11 | Actelion Pharmaceuticals Ltd | Novel pyrimidine-pyridine derivatives |
| JP5411877B2 (en) * | 2008-03-06 | 2014-02-12 | アクテリオン ファーマシューティカルズ リミテッド | Pyridine compounds |
| KR101615779B1 (en) * | 2008-03-07 | 2016-04-26 | 액테리온 파마슈티칼 리미티드 | Pyridin-2-yl derivatives as immunomodulating agents |
| EP2262782B1 (en) * | 2008-03-07 | 2012-07-04 | Actelion Pharmaceuticals Ltd. | Novel aminomethyl benzene derivatives |
| PT2291080E (en) | 2008-05-14 | 2015-10-30 | Scripps Research Inst | Novel modulators of sphingosine phosphate receptors |
| RU2547098C2 (en) * | 2009-07-16 | 2015-04-10 | Актелион Фармасьютиклз Лтд | Pyrimidin-4-yl derivatives |
-
2008
- 2008-08-14 WO PCT/IB2008/053269 patent/WO2009024905A1/en active Application Filing
- 2008-08-14 BR BRPI0815190 patent/BRPI0815190A2/en not_active IP Right Cessation
- 2008-08-14 RU RU2010109542/04A patent/RU2492168C2/en not_active IP Right Cessation
- 2008-08-14 AU AU2008290233A patent/AU2008290233B2/en not_active Ceased
- 2008-08-14 MX MX2010001881A patent/MX2010001881A/en active IP Right Grant
- 2008-08-14 PL PL08789611T patent/PL2195311T3/en unknown
- 2008-08-14 SI SI200830269T patent/SI2195311T1/en unknown
- 2008-08-14 DK DK08789611.4T patent/DK2195311T3/en active
- 2008-08-14 ES ES08789611T patent/ES2361463T3/en active Active
- 2008-08-14 KR KR1020107005759A patent/KR101541558B1/en not_active IP Right Cessation
- 2008-08-14 NZ NZ583957A patent/NZ583957A/en not_active IP Right Cessation
- 2008-08-14 DE DE602008005770T patent/DE602008005770D1/en active Active
- 2008-08-14 MY MYPI2010000684A patent/MY153975A/en unknown
- 2008-08-14 US US12/673,918 patent/US8598208B2/en not_active Expired - Fee Related
- 2008-08-14 AT AT08789611T patent/ATE502938T1/en active
- 2008-08-14 EP EP08789611A patent/EP2195311B1/en not_active Not-in-force
- 2008-08-14 JP JP2010520670A patent/JP5451614B2/en not_active Expired - Fee Related
- 2008-08-14 CA CA2695509A patent/CA2695509A1/en not_active Abandoned
- 2008-08-14 PT PT08789611T patent/PT2195311E/en unknown
- 2008-08-14 CN CN200880103070.2A patent/CN102648198B/en not_active Expired - Fee Related
- 2008-08-15 TW TW097131346A patent/TWI422373B/en not_active IP Right Cessation
- 2008-08-19 AR ARP080103611A patent/AR067977A1/en not_active Application Discontinuation
-
2010
- 2010-03-12 MA MA32693A patent/MA31703B1/en unknown
- 2010-03-16 ZA ZA2010/01873A patent/ZA201001873B/en unknown
- 2010-12-03 HK HK10111281.3A patent/HK1144809A1/en not_active IP Right Cessation
-
2011
- 2011-05-30 CY CY20111100521T patent/CY1111830T1/en unknown
- 2011-06-16 HR HR20110449T patent/HRP20110449T1/en unknown
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