MA29266B1 - TREATMENT OF METASTATIC TUMORS - Google Patents

TREATMENT OF METASTATIC TUMORS

Info

Publication number
MA29266B1
MA29266B1 MA30162A MA30162A MA29266B1 MA 29266 B1 MA29266 B1 MA 29266B1 MA 30162 A MA30162 A MA 30162A MA 30162 A MA30162 A MA 30162A MA 29266 B1 MA29266 B1 MA 29266B1
Authority
MA
Morocco
Prior art keywords
treatment
compound
metastatic tumors
tautomer
pharmaceutically acceptable
Prior art date
Application number
MA30162A
Other languages
French (fr)
Inventor
De Menezes Daniel Lopes
Carla Heise
Xiaohua Xin
Original Assignee
Novartis Vaccines & Diagnostic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36741085&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA29266(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Vaccines & Diagnostic filed Critical Novartis Vaccines & Diagnostic
Publication of MA29266B1 publication Critical patent/MA29266B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

The present invention relates to a compound of Structure I, a tautomer of the compound, a pharmaceutically acceptable salt of the compound, a pharmaceutically acceptable salt of the tautomer, or a mixture thereof, for use in methods of treating metastatic cancer such as metastasized tumors in a subject. The variable A has the values defined herein.
MA30162A 2005-01-27 2007-08-23 TREATMENT OF METASTATIC TUMORS MA29266B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64756805P 2005-01-27 2005-01-27
US66924505P 2005-04-06 2005-04-06
US72205305P 2005-09-29 2005-09-29

Publications (1)

Publication Number Publication Date
MA29266B1 true MA29266B1 (en) 2008-02-01

Family

ID=36741085

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30162A MA29266B1 (en) 2005-01-27 2007-08-23 TREATMENT OF METASTATIC TUMORS

Country Status (23)

Country Link
US (2) US20060183750A1 (en)
EP (2) EP2301546B1 (en)
JP (2) JP5371246B2 (en)
KR (1) KR101387985B1 (en)
CN (1) CN103893181A (en)
AT (1) ATE526025T1 (en)
AU (1) AU2006208012B2 (en)
BR (1) BRPI0607285A2 (en)
CA (1) CA2596084A1 (en)
CY (1) CY1112570T1 (en)
DK (1) DK1845990T3 (en)
ES (2) ES2525670T3 (en)
HK (1) HK1155664A1 (en)
IL (1) IL184866A0 (en)
MA (1) MA29266B1 (en)
MX (1) MX2007009099A (en)
NO (1) NO20074360L (en)
PL (2) PL2301546T3 (en)
PT (2) PT2301546E (en)
SG (1) SG173317A1 (en)
SI (1) SI2301546T1 (en)
TN (1) TNSN07294A1 (en)
WO (1) WO2006081445A2 (en)

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AU2001293233A1 (en) 2000-09-01 2002-03-13 Chiron Corporation Aza heterocyclic derivatives and their therapeutic use
EP2573079A3 (en) 2002-08-23 2015-03-11 Novartis AG Benzimidazole quinolinones and uses thereof
MX2007014206A (en) * 2005-05-13 2008-02-07 Novartis Ag Methods for treating drug resistant cancer.
EP2270000B1 (en) * 2005-05-23 2015-07-29 Novartis AG Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one lactic acid salts
PE20091628A1 (en) * 2008-03-19 2009-11-19 Novartis Ag CRYSTALLINE FORMS AND TWO SOLVATED FORMS OF LACTIC ACID SALTS OF 4-AMINO-5-FLUORO-3- [5- (4-METHYLPIPERAZIN-1-IL) -1H-BENZIMIDAZOL-2-IL] QUINOLIN-2 (1H) - ONA
EP2432451A2 (en) * 2009-05-20 2012-03-28 Children's Medical Center Corporation Compositions for the treatment of metastatic cancer and methods of use thereof
PL2558095T3 (en) * 2010-04-16 2019-06-28 Novartis Ag Organic compound for use in the treatment of liver cancer
EP2709729A1 (en) * 2011-05-19 2014-03-26 Novartis AG 4-amino-5-fluoro-3- [6- (4 -methylpiperazin- 1 - yl) - 1h - benzimidazol - 2 - yl]- 1h - quinoli n-2-one for use in the treatment of adenoid cystic carcinoma
WO2013116293A1 (en) * 2012-01-31 2013-08-08 Novartis Ag Combination of a rtk inhibitor with an anti - estrogen and use thereof for the treatment of cancer
JP6990228B2 (en) * 2016-07-14 2022-01-13 ブリストル－マイヤーズ スクイブ カンパニー Bicyclic heteroaryl substituted compound

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US4659657A (en) * 1982-12-24 1987-04-21 Bayer Aktiengesellschaft Chromogenic and fluorogenic esters for photometric or fluorimetric determination of phosphatases or sulphatases
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Also Published As

Publication number Publication date
IL184866A0 (en) 2007-12-03
CN103893181A (en) 2014-07-02
TNSN07294A1 (en) 2008-12-31
PL2301546T3 (en) 2015-03-31
KR20070118596A (en) 2007-12-17
EP1845990B1 (en) 2011-09-28
KR101387985B1 (en) 2014-04-25
EP1845990A4 (en) 2008-04-30
EP1845990A2 (en) 2007-10-24
SG173317A1 (en) 2011-08-29
NO20074360L (en) 2007-10-25
BRPI0607285A2 (en) 2009-08-25
DK1845990T3 (en) 2012-01-02
ATE526025T1 (en) 2011-10-15
CY1112570T1 (en) 2016-02-10
JP2008528617A (en) 2008-07-31
PT1845990E (en) 2011-12-23
WO2006081445A3 (en) 2007-01-11
ES2374570T3 (en) 2012-02-17
EP2301546B1 (en) 2014-09-10
JP5371246B2 (en) 2013-12-18
JP2013177464A (en) 2013-09-09
WO2006081445A2 (en) 2006-08-03
AU2006208012A1 (en) 2006-08-03
US20100173873A1 (en) 2010-07-08
CA2596084A1 (en) 2006-08-03
ES2525670T3 (en) 2014-12-29
MX2007009099A (en) 2007-09-13
PT2301546E (en) 2014-12-18
SI2301546T1 (en) 2015-01-30
PL1845990T3 (en) 2012-02-29
AU2006208012B2 (en) 2011-08-04
HK1155664A1 (en) 2012-05-25
US20060183750A1 (en) 2006-08-17
EP2301546A1 (en) 2011-03-30

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