LV15002A - Heterociklā aizvietoti [(2-karboksi vai -metoksikarbonil)fenilkarbamoil-metil (vai trimetilēn)] piridīnija vai izohinolīnija bromīdi kā hidroksikarbonskābju receptoru saimes (HCA2) jauna ligandu klase - Google Patents

Heterociklā aizvietoti [(2-karboksi vai -metoksikarbonil)fenilkarbamoil-metil (vai trimetilēn)] piridīnija vai izohinolīnija bromīdi kā hidroksikarbonskābju receptoru saimes (HCA2) jauna ligandu klase

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Publication number
LV15002A
LV15002A LVP-13-164A LV130164A LV15002A LV 15002 A LV15002 A LV 15002A LV 130164 A LV130164 A LV 130164A LV 15002 A LV15002 A LV 15002A
Authority
LV
Latvia
Prior art keywords
trimethylen
phenylcarbamoyl
pyridinium
methoxycarbonyl
ligands
Prior art date
Application number
LVP-13-164A
Other languages
English (en)
Other versions
LV15002B (lv
Inventor
Brigita VĪGANTE
Iveta Luntēna
Zenta Kalme
Egils Bisenieks
Jānis Poikāns
Ramona PETROVSKA
Ilona Mandrika
Jānis Kloviņš
Einārs Loža
Imanta Brūvere
Gunārs DUBURS
Jānis ULDRIĶIS
Original Assignee
Latvijas Organiskās Sintēzes Institūts
Latvijas Biomedicīnas Pētījumu Un Studiju Centrs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Latvijas Organiskās Sintēzes Institūts, Latvijas Biomedicīnas Pētījumu Un Studiju Centrs filed Critical Latvijas Organiskās Sintēzes Institūts
Priority to LVP-13-164A priority Critical patent/LV15002B/lv
Publication of LV15002A publication Critical patent/LV15002A/lv
Publication of LV15002B publication Critical patent/LV15002B/lv

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Izgudrojums attiecas uz bioķīmiju un medicīnu, konkrēti uz heterociklā aizvietotiem [(2-karboksi vai -metoksikarbonil)fenilkarbamoil-metil (vai trimetilēn)]-piridīnija vai izohinolīnija bromīdiem kā hidroksikarbonskābju receptoru (HCA) saimes (t.sk., niacīna grupas) ligandiem, kas izmantojami medicīnā lipīdu, holesterīna un cukura vielmaiņas, kā arī aterosklerotisku un iekaisuma procesu normalizēšanai un ārstēšanai.
LVP-13-164A 2013-10-29 2013-10-29 Heterociklā aizvietoti [(2-karboksi vai -metoksikarbonil)fenilkarbamoil-metil (vai trimetilēn)] piridīnija vai izohinolīnija bromīdi kā hidroksikarbonskābju receptoru saimes (HCA2) jauna ligandu klase LV15002B (lv)

Priority Applications (1)

Application Number Priority Date Filing Date Title
LVP-13-164A LV15002B (lv) 2013-10-29 2013-10-29 Heterociklā aizvietoti [(2-karboksi vai -metoksikarbonil)fenilkarbamoil-metil (vai trimetilēn)] piridīnija vai izohinolīnija bromīdi kā hidroksikarbonskābju receptoru saimes (HCA2) jauna ligandu klase

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LVP-13-164A LV15002B (lv) 2013-10-29 2013-10-29 Heterociklā aizvietoti [(2-karboksi vai -metoksikarbonil)fenilkarbamoil-metil (vai trimetilēn)] piridīnija vai izohinolīnija bromīdi kā hidroksikarbonskābju receptoru saimes (HCA2) jauna ligandu klase

Publications (2)

Publication Number Publication Date
LV15002A true LV15002A (lv) 2015-05-20
LV15002B LV15002B (lv) 2015-07-20

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Family Applications (1)

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LVP-13-164A LV15002B (lv) 2013-10-29 2013-10-29 Heterociklā aizvietoti [(2-karboksi vai -metoksikarbonil)fenilkarbamoil-metil (vai trimetilēn)] piridīnija vai izohinolīnija bromīdi kā hidroksikarbonskābju receptoru saimes (HCA2) jauna ligandu klase

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LV (1) LV15002B (lv)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10927096B2 (en) * 2019-03-11 2021-02-23 Nocion Therapeutics, Inc. Ester substituted ion channel blockers and methods for use

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020237474A1 (en) * 2019-03-11 2021-09-30 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US11377422B2 (en) 2019-03-11 2022-07-05 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US10828287B2 (en) 2019-03-11 2020-11-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
KR20220123381A (ko) 2019-11-06 2022-09-06 녹시온 테라퓨틱스 인코포레이티드 하전된 이온 채널 차단제 및 사용 방법
US10933055B1 (en) 2019-11-06 2021-03-02 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
EP4118070A4 (en) 2020-03-11 2024-04-10 Nocion Therapeutics, Inc. CHARGED ION CHANNEL BLOCKERS AND METHODS OF USE

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10927096B2 (en) * 2019-03-11 2021-02-23 Nocion Therapeutics, Inc. Ester substituted ion channel blockers and methods for use

Also Published As

Publication number Publication date
LV15002B (lv) 2015-07-20

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