LV12540A - 7-Alkylidene-substituted derivatives of cephalosporins having citotoxic activity - Google Patents

7-Alkylidene-substituted derivatives of cephalosporins having citotoxic activity

Info

Publication number
LV12540A
LV12540A LV990048A LV990048A LV12540A LV 12540 A LV12540 A LV 12540A LV 990048 A LV990048 A LV 990048A LV 990048 A LV990048 A LV 990048A LV 12540 A LV12540 A LV 12540A
Authority
LV
Latvia
Prior art keywords
alkoxycarbonyl
compounds
cephalosporins
alkylidene
substituted derivatives
Prior art date
Application number
LV990048A
Other versions
LV12540B (en
Inventor
Iveta Kanepe
Grigorijs Veinbergs
Maksims Vorona
Irina Sestakova
Ilona Domracova
Ivars Kalvins
Lukevics Edmunds
Original Assignee
Latvijas Organiskas Sintezes Instituts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Latvijas Organiskas Sintezes Instituts filed Critical Latvijas Organiskas Sintezes Instituts
Priority to LVP-99-48A priority Critical patent/LV12540B/en
Publication of LV12540A publication Critical patent/LV12540A/en
Publication of LV12540B publication Critical patent/LV12540B/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

The present invention relates to the pharmacologically active substances, particularly to cytotoxic agents for cancer chemotherapy. The mentioned compounds contain modified tert-butyl 7-methylenecephalosporanoates 1-oxide or 1,1-dioxides, in which the substituents in a 7-methylene group are specially selected from alkoxycarbonyl, alkoxycarbonyl ethylene, propinyl, aryl and heteroaryl. The majority of the compounds claimed possess cytotoxic properties against monolayer HT 1080, MG-22A, B 16 and Neuro 2A cell lines killing 50 % of cells in concentrations less than 10 mg/ml. The invented compounds are characterised by low toxicity against normal fibroblast cells and by a positive therapeutic effect in the treatment of melanoma (B 16) and sarcoma (S-180) tumor strains.
LVP-99-48A 1999-03-23 1999-03-23 7-alkylidene-substituted derivatives of cephalosporins having citotoxic activity LV12540B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
LVP-99-48A LV12540B (en) 1999-03-23 1999-03-23 7-alkylidene-substituted derivatives of cephalosporins having citotoxic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LVP-99-48A LV12540B (en) 1999-03-23 1999-03-23 7-alkylidene-substituted derivatives of cephalosporins having citotoxic activity

Publications (2)

Publication Number Publication Date
LV12540A true LV12540A (en) 2000-10-20
LV12540B LV12540B (en) 2000-12-20

Family

ID=19736579

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-99-48A LV12540B (en) 1999-03-23 1999-03-23 7-alkylidene-substituted derivatives of cephalosporins having citotoxic activity

Country Status (1)

Country Link
LV (1) LV12540B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130079318A1 (en) * 2008-05-13 2013-03-28 Southern Methodist University Beta-lactamase inhibitory compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130079318A1 (en) * 2008-05-13 2013-03-28 Southern Methodist University Beta-lactamase inhibitory compounds

Also Published As

Publication number Publication date
LV12540B (en) 2000-12-20

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