LV12540A - 7-Alkylidene-substituted derivatives of cephalosporins having citotoxic activity - Google Patents
7-Alkylidene-substituted derivatives of cephalosporins having citotoxic activityInfo
- Publication number
- LV12540A LV12540A LV990048A LV990048A LV12540A LV 12540 A LV12540 A LV 12540A LV 990048 A LV990048 A LV 990048A LV 990048 A LV990048 A LV 990048A LV 12540 A LV12540 A LV 12540A
- Authority
- LV
- Latvia
- Prior art keywords
- alkoxycarbonyl
- compounds
- cephalosporins
- alkylidene
- substituted derivatives
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
The present invention relates to the pharmacologically active substances, particularly to cytotoxic agents for cancer chemotherapy. The mentioned compounds contain modified tert-butyl 7-methylenecephalosporanoates 1-oxide or 1,1-dioxides, in which the substituents in a 7-methylene group are specially selected from alkoxycarbonyl, alkoxycarbonyl ethylene, propinyl, aryl and heteroaryl. The majority of the compounds claimed possess cytotoxic properties against monolayer HT 1080, MG-22A, B 16 and Neuro 2A cell lines killing 50 % of cells in concentrations less than 10 mg/ml. The invented compounds are characterised by low toxicity against normal fibroblast cells and by a positive therapeutic effect in the treatment of melanoma (B 16) and sarcoma (S-180) tumor strains.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LVP-99-48A LV12540B (en) | 1999-03-23 | 1999-03-23 | 7-alkylidene-substituted derivatives of cephalosporins having citotoxic activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LVP-99-48A LV12540B (en) | 1999-03-23 | 1999-03-23 | 7-alkylidene-substituted derivatives of cephalosporins having citotoxic activity |
Publications (2)
Publication Number | Publication Date |
---|---|
LV12540A true LV12540A (en) | 2000-10-20 |
LV12540B LV12540B (en) | 2000-12-20 |
Family
ID=19736579
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LVP-99-48A LV12540B (en) | 1999-03-23 | 1999-03-23 | 7-alkylidene-substituted derivatives of cephalosporins having citotoxic activity |
Country Status (1)
Country | Link |
---|---|
LV (1) | LV12540B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130079318A1 (en) * | 2008-05-13 | 2013-03-28 | Southern Methodist University | Beta-lactamase inhibitory compounds |
-
1999
- 1999-03-23 LV LVP-99-48A patent/LV12540B/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130079318A1 (en) * | 2008-05-13 | 2013-03-28 | Southern Methodist University | Beta-lactamase inhibitory compounds |
Also Published As
Publication number | Publication date |
---|---|
LV12540B (en) | 2000-12-20 |
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